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(2-Trifluoromethyl-pyridin-3-yl)-methanol

(2-Trifluoromethyl-pyridin-3-yl)-methanol Structure
(2-Trifluoromethyl-pyridin-3-yl)-methanol structure
CAS No.
131747-57-4
Chemical Name:
(2-Trifluoromethyl-pyridin-3-yl)-methanol
Synonyms
2-(Trifluoromethyl)-3-pyridinemethanol;2-(Trifluoromethyl)pyridine-3-methanol;2-(trifluoromethyl)-3-pyridyl]methanol;3-pyridineMethanol, 2-(trifluoroMethyl)-;(2-Trifluoromethyl-pyridin-3-yl)-methanol;(2-trifluoromethyl pyridine-3-yl) -methanol
CBNumber:
CB81553840
Molecular Formula:
C7H6F3NO
Molecular Weight:
177.12
MDL Number:
MFCD11100743
MOL File:
131747-57-4.mol
MSDS File:
SDS
Last updated:2026-05-28 04:57:49
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(2-Trifluoromethyl-pyridin-3-yl)-methanol Properties

Boiling point 209℃
Density 1.362
Flash point 80℃
storage temp. Sealed in dry,Room Temperature
pka 13.08±0.10(Predicted)
Appearance Light yellow to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933399990

(2-Trifluoromethyl-pyridin-3-yl)-methanol price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC905183 (2-(Trifluoromethyl)pyridin-3-yl)methanol 95% 131747-57-4 1g $97 2026-06-04 Buy
Apolloscientific PC905183 (2-(Trifluoromethyl)pyridin-3-yl)methanol 95% 131747-57-4 5g $361 2026-06-04 Buy
Activate Scientific AS147669 (2-(Trifluoromethyl)pyridin-3-yl)methanol 95% 131747-57-4 1g $93 2026-06-04 Buy
Activate Scientific AS147669 (2-(Trifluoromethyl)pyridin-3-yl)methanol 95% 131747-57-4 5g $329 2026-06-04 Buy
Synthonix T63957 (2-(Trifluoromethyl)pyridin-3-yl)methanol >98% 131747-57-4 250mg $51 2026-05-06 Buy
Product number Packaging Price Buy
PC905183 1g $97 Buy
PC905183 5g $361 Buy
AS147669 1g $93 Buy
AS147669 5g $329 Buy
T63957 250mg $51 Buy

(2-Trifluoromethyl-pyridin-3-yl)-methanol Chemical Properties, Uses, Production

Synthesis

2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER

208517-35-5

(2-Trifluoromethyl-pyridin-3-yl)-methanol

131747-57-4

General procedure for the synthesis of (2-trifluoromethyl-pyridin-3-yl)-methanol from ethyl 2-trifluoromethylnicotinate: sodium borohydride (0.35 g, 9.1 mmol) was suspended in anhydrous tetrahydrofuran (20 mL). Anhydrous tetrahydrofuran solution (20 mL) of ethyl 2-trifluoromethylnicotinate (1.00 g, 0.46 mmol) was added dropwise to the stirred suspension under ice bath cooling. The reaction mixture was stirred at 4°C for 16 hours. Upon completion of the reaction, methanol (5 mL) was added to quench the residual sodium borohydride, followed by the addition of 15% aqueous sodium hydroxide solution (25 mL). The resulting mixture was continued to be stirred at 25 °C for 30 min, followed by removal of tetrahydrofuran and methanol by rotary evaporation. The remaining aqueous phase was extracted with ethyl acetate (3 x 25 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated by rotary evaporation to afford the target product (2-trifluoromethyl-pyridin-3-yl)-methanol as a yellow oil (0.61 g, 75% yield), which could be used in subsequent reactions without further purification. The product was characterized by 1H-NMR (CDCl3): δ 8.64 (d, J = 4.5 Hz, 1H), 8.17 (d, J = 8.0 Hz, 1H), 7.57 (dd, J = 8.0, 4.5 Hz, 1H), 4.98 (s, 2H), 1.99 (s, 1H). Mass spectrum (ESI+): m/z (M + H)+ = 178.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 5352 - 5359
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 12, p. 2146 - 2163
[3] Synthesis, 2005, # 16, p. 2751 - 2757
[4] Patent: WO2015/187934, 2015, A1. Location in patent: Paragraph 0228

(2-Trifluoromethyl-pyridin-3-yl)-methanol Preparation Products And Raw materials

Raw materials

2-(Trifluoromethyl)-3-pyridinecarboxylic acid ethyl ester Sodium borohydride Tetrahydrofuran

Preparation Products

(2-Trifluoromethyl-pyridin-3-yl)-methanol Suppliers

Global Suppliers ( 85)
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
Nan Jing Dirise Chemcial Co.,LTD 025-52161033 15312098939 2432674894@qq.com China 585 64
SynAsst Chemical. 021-60343070 China 12731 55
Shanghai Carlow Chemicals Co., Ltd. 21-33526724 18930996265 info@carlowchem.com China 1996 58
Cochemical Ltd. 029-86115547 17791676824 sales@cochemical.com China 3014 58
Shanghai YuLue Chemical Co., Ltd. 021-60345187 13671753212 lzz841106@aliyun.com China 10244 55
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Capot Chemical Co., Ltd 66
Nanjing Chemlin Chemical Co., Ltd 64
China DongFan Chemical Co.,LTD 66
Nan Jing Dirise Chemcial Co.,LTD 64
SynAsst Chemical. 55
Shanghai Carlow Chemicals Co., Ltd. 58
Cochemical Ltd. 58
Shanghai YuLue Chemical Co., Ltd. 55

(2-Trifluoromethyl-pyridin-3-yl)-methanol Spectrum

(2-Trifluoromethyl-pyridin-3-yl)-methanol(131747-57-4)1HNMR

131747-57-4 ((2-Trifluoromethyl-pyridin-3-yl)-methanol) Related Search:

2-(Trifluoromethyl)nicotinic acid Ethyl 2-chloro-3-cyano-6-(trifluoromethyl)-pyridine-5-carboxylate 2-(Trifluoromethyl)-1,8-naphthyridine-3-carboxylic acid 1,8-Naphthyridine-3-carboxylicacid,2-(trifluoromethyl)-,ethylester(9CI) Diethyl 3-amino-6-(trifluoromethyl)thieno[2,3-b]pyridine-2,5-dicarboxylate
2-(Trifluoromethyl)-1,6-naphthyridine-3-carboxylic acid Ethyl 5-cyano-6-methyl-2-(trifluoromethyl)nicotinate 6-Methyl-5-(4-phenyl-1,3-thiazol-2-yl)-2-(trifluoromethyl)nicotinic acid 5-(Trifluoromethyl)thieno[3,2-b]pyridine-6-carboxylicacid 5-(Trifluoromethyl)thieno[3,2-b]pyridine-6-carboxylic acid, ethyl ester
2-(Trifluoromethyl)-1,6-naphthyridine-3-carboxylic ethyl ester 2-(Difluoromethyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3,5-pyridinedicarboxylic acid, 5-methyl ester Ethyl 5-cyano-6-([2-(([(2,6-dichloro-4-pyridyl)amino]carbonyl)amino)phenyl]thio)-2-(trifluoromethyl)nicotinate Diethyl 2-methyl-6-(trifluoromethyl)pyridine-3,5-dicarboxylate 6-Hydroxy-5-(2-hydroxybenzoyl)-2-(trifluoromethyl)nicotinic acid
BUTTPARK 82\12-87 5-Oxo-2-(trifluoromethyl)-5H-chromeno[2,3-b]pyridine-3-carboxylic acid Ethyl 5-oxo-2-(trifluoromethyl)-5H-chromeno[2,3-b]pyridine-3-carboxylate

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(2-Trifluoromethyl-pyridin-3-yl)-methanol 2-(Trifluoromethyl)pyridine-3-methanol 3-pyridineMethanol, 2-(trifluoroMethyl)- 2-(trifluoromethyl)-3-pyridyl]methanol (2-trifluoromethyl pyridine-3-yl) -methanol 2-(Trifluoromethyl)-3-pyridinemethanol 131747-57-4 Building Blocks Pyridine