2-(3-bromopyridin-2-yl)acetonitrile
- CAS No.
- 122851-60-9
- Chemical Name:
- 2-(3-bromopyridin-2-yl)acetonitrile
- Synonyms
- 3-BroMo-2-pyridineacetonitrile;3-Bromopyridine-2-acetonitrile;2-Pyridineacetonitrile, 3-bromo-;2-(3-Bromo-2-pyridyl)acetonitrile;(3-BROMOPYRIDIN-2-YL)ACETONITRILE;2-(3-bromopyridin-2-yl)acetonitrile
- CBNumber:
- CB81556957
- Molecular Formula:
- C7H5BrN2
- Molecular Weight:
- 197.03
- MDL Number:
- MFCD09999977
- MOL File:
- 122851-60-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2933399990 |
2-(3-bromopyridin-2-yl)acetonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | XEA85160 | 2-(3-Bromopyridin-2-yl)acetonitrile | 122851-60-9 | 2.5g | $413 | 2026-06-05 | Buy |
| Apolloscientific | OR901848 | 2-(3-Bromopyridin-2-yl)acetonitrile 98% | 122851-60-9 | 250mg | $28 | 2026-06-04 | Buy |
| Apolloscientific | OR901848 | 2-(3-Bromopyridin-2-yl)acetonitrile 98% | 122851-60-9 | 1g | $77 | 2026-06-04 | Buy |
| Apolloscientific | OR901848 | 2-(3-Bromopyridin-2-yl)acetonitrile 98% | 122851-60-9 | 5g | $374 | 2026-06-04 | Buy |
| Apolloscientific | OR901848 | 2-(3-Bromopyridin-2-yl)acetonitrile 98% | 122851-60-9 | 25g | $1454 | 2026-06-04 | Buy |
2-(3-bromopyridin-2-yl)acetonitrile Chemical Properties, Uses, Production
Synthesis
13534-89-9
75-05-8
122851-60-9
General procedure for the synthesis of 3-bromo-2-pyridineacetonitrile from 2,3-dibromopyridine and acetonitrile: A tetrahydrofuran (THF, 8 mL) solution of acetonitrile (87 mg, 2.13 mmol) was slowly added to a THF solution of n-butyllithium (n-BuLi, 1.78 mL, 4.26 mmol) at -78 °C and stirred for 1 hour at -78 °C. Subsequently, a THF (2 mL) solution of 2,3-dibromopyridine (500 mg, 2.13 mmol) was slowly added at the same temperature. The reaction mixture was continued to be stirred at -78 °C for 1.5 h and then slowly warmed up to room temperature. Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride (NH4Cl) solution and the organic phase was extracted with ethyl acetate (EA, 100 mL x 3). The combined organic phases were washed with brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by preparative high performance liquid chromatography (HPLC) with the mobile phase of acetonitrile/water (containing 10 nM ammonium bicarbonate, NH4HCO3) to afford the target product 3-bromo-2-pyridineacetonitrile (110 mg, 22% yield) as a white solid. Liquid chromatography-mass spectrometry (LCMS) analysis showed [MH]+ = 197.
References
[1] Synlett, 2000, # 10, p. 1488 - 1490
[2] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00161
[3] Patent: US2012/277247, 2012, A1. Location in patent: Page/Page column 12
2-(3-bromopyridin-2-yl)acetonitrile Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Zhengzhou HSH Science & Technology Co., Ltd. | 0371-55932928 18937192232; | 1282296214@qq.com | China | 497 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
| Zhengzhou AiXi Technology Co., Ltd. | 0371-56787280 13137706083 | m18539565376@163.com | China | 999 | 55 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-20242659 18930833303 | sales@changyanchem.cn | China | 4998 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai Pingguo Pharmaceutical Co., Ltd. | 021-20432229 | 2412110556@qq.com | China | 6016 | 55 |
