Vanillyl butyl ether
- CAS No.
- 82654-98-6
- Chemical Name:
- Vanillyl butyl ether
- Synonyms
- Vanillyl Butyl;BUTYL VANILLYL ETHER;FEMA 3796;4-(Butoxymethyl)-2-methoxyphenol;4-(Butoxymethyl);Vanillyl butyl eth;BUTYL VANILLY ETHER;Vanilly butyl ether;VANILLYL BUTYL ETHER;Vanillin butyl ether
- CBNumber:
- CB8156299
- Molecular Formula:
- C12H18O3
- Molecular Weight:
- 210.27
- MDL Number:
- MFCD00238529
- MOL File:
- 82654-98-6.mol
- MSDS File:
- SDS
| Boiling point | 241 °C(lit.) |
|---|---|
| Density | 1.057 g/mL at 25 °C(lit.) |
| vapor pressure | 0.42-2000Pa at 20-25℃ |
| refractive index |
n |
| FEMA | 3796 | VANILLYL BUTYL ETHER |
| FLAVIS Number | 04.093 | Butyl vanillyl ether |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble (Insoluble in water. Soluble in organic solvents, oils.) |
| form | Oil |
| color | Colourless |
| Specific Gravity | 1.057 |
| Odor | at 100.00 %. vanilla fruity |
| Odor Type | vanilla |
| biological source | synthetic |
| Water Solubility | 1.79-1690mg/L at 20℃ |
| JECFA Number | 888 |
| Major Application | flavors and fragrances |
| Cosmetics Ingredients Functions |
FRAGRANCE SKIN CONDITIONING ORAL CARE HAIR CONDITIONING |
| InChI | 1S/C12H18O3/c1-3-4-7-15-9-10-5-6-11(13)12(8-10)14-2/h5-6,8,13H,3-4,7,9H2,1-2H3 |
| InChIKey | VLDFMKOUUQYFGF-UHFFFAOYSA-N |
| SMILES | CCCCOCC1=CC(OC)=C(O)C=C1 |
| LogP | 2.2-2.4 at 23-25℃ |
| Substances Added to Food (formerly EAFUS) | VANILLYL BUTYL ETHER |
| EWG's Food Scores | 1 |
| FDA UNII | S2ULN37C9R |
| EPA Substance Registry System | Phenol, 4-(butoxymethyl)-2-methoxy- (82654-98-6) |
| UNSPSC Code | 12164502 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H317 | |||||||||
| Precautionary statements | P501-P261-P272-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P333+P313 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 2909.50.4050 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Vanillyl butyl ether price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W379620 | Vanillyl butyl ether ≥96%, FG | 82654-98-6 | 1 each | $59.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | W379601 | Vanillyl butyl ether natural (US), 97%, FG | 82654-98-6 | 1 each | $63.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | W379601 | Vanillyl butyl ether natural (US), 97%, FG | 82654-98-6 | 100g | $208 | 2026-04-30 | Buy |
| Sigma-Aldrich | W379601 | Vanillyl butyl ether natural (US), 97%, FG | 82654-98-6 | 500g | $803 | 2026-04-30 | Buy |
| Sigma-Aldrich | W379601 | Vanillyl butyl ether natural (US), 97%, FG | 82654-98-6 | 1kg | $1360 | 2026-04-30 | Buy |
Vanillyl butyl ether Chemical Properties, Uses, Production
Description
Vanillyl butyl ether(82654-98-6) is an ether of monohydroxybenzoic acid. It is added to food products as a flavoring agent. It is also present in cosmetics and personal care products. It has a characteristic trigeminal, burning, hot pepper nature and can be used in spice flavors like pepper, cinnamon and ginger, as well as blends for some baked applications, including cookies. It has some other applications include flavoring for alcoholic and non-alcoholic beverages with herbal, berry, vanilla, cola, ginger ale, root beer, hot chocolate, chai, ice tea and mints. It can also be used as a warming agent.
Description
Vanillyl butyl ether is an ether of monohydroxybenzoic acid. It is added to food products as a flavoring agent. It is also present in cosmetics and personal care products as a fragrance ingredient, oral care agent, hair conditioning agent, and warming or cooling agent.
Chemical Properties
Vanillyl butyl ether has a weak, vanillic, acidic odor.
Uses
Vanillyl butyl ether is a compound hypothesized to have warming and vasodilation mechanisms when applied on the skin as a cream.
General Description
Vanillyl butyl ether is an alkoxy-substituted benzyl derivative mainly used as a flavoring agent.
Biochem/physiol Actions
Taste at 10-15%
Side effects
Vanilloids contain vanillyl groups that bind to the transient receptor potential type V1 channel (Vanilloid receptor-1, TRPV1) that respond to noxious stimuli such as high temperatures and acidic pH. This causes neurons to release glutamate, adenosine triphosphate (ATP) and a variety of neuropeptides, resulting in the warming sensation. Vanillyl butyl ether causes serious eye irritation and may cause an allergic skin reaction.
Safety
Vanillyl butyl ether (VBE) is a weak skin sensitizer, which is a substance whose chemical structure indicates that it is expected to react with skin proteins, with a NESIL value of 3500 μg/cm2. VBE is not genotoxic, phototoxic or photosensitizing. In addition, VBE is not persistent, bioaccumulative and toxic (PBT) according to IFRA environmental criteria, and its risk quotient is less than 1 based on its current use in Europe and North America (i.e. PEC/PNEC). The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for Cramer Class III materials, and exposure to VBE was below the TTC (0.47 mg/day)[1].
Synthesis
At present, the synthesis of vanillyl butyl ether is mainly obtained by dehydrating and condensing vanillyl alcohol and n-butyl alcohol under an acid catalyst. However, the yield of the method is low mainly because water generated by the reaction can inhibit the etherification reaction. The common acid catalyst such as AlCl is used3、FeCl3It is easy to hydrolyze in the presence of water and lose its catalytic action. A new synthesis method comprises the following steps: dissolving vanillin in a solvent, adding a metal complex hydride and an alkylating reagent after uniformly stirring, reacting for 3-4 hours at 30-40 ℃ to obtain a vanillin alcohol ether solution, and separating and purifying the vanillin alcohol ether solution to obtain vanillin alcohol ether.
References
[1] A.M. API . RIFM fragrance ingredient safety assessment, vanillyl butyl ether, CAS Registry Number 82654-98-6[J]. Food and Chemical Toxicology, 2021, 153: Article 112361. DOI:10.1016/j.fct.2021.112361.
Vanillyl butyl ether Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Ji`an Borui Spice Oil Co., Ltd. | 0796-0796-8181760 13361763840 | 3142054383@qq.com | China | 28 | 58 |
| Jiangxi Zhonghuan Biotechnology Co., Ltd | 0796-8107286 13766287383 | 1350877100@qq.com | China | 165 | 58 |
| Beri Pharma Co., Ltd. | 0756-8699456 13427714006 | sales@zhberi.com | China | 199 | 58 |
| Ji 'an trillion spice oil co. LTD | 0796-0796-8110986 19979632110 | wanlu1208@gmail.com | China | 119 | 58 |
| Jiangxi Planty Manor Health Industry Co., Ltd. | 0796-18507969315 18507969315 | 3686433662@qq.com | China | 264 | 58 |
| Jishui Hongxing Natural Medicinal Flavor Oil Factory | 18307968169 | 2693078805@qq.com | China | 20 | 58 |
| Henan Sakesi Biotechnology Co. , Ltd | 13803717460 | yf79009@163.com | China | 175 | 58 |
| Jiangxi Jingwang Natural Spice Oil Co. Ltd | 0796-8181760 15270068652 | 2408895395@qq.com | China | 28 | 58 |
| ZHENYOU LIAO (WUHAN) BIOTECHNOLOGY CO., LTD. | 18062454418 | info@zenunite-bio.com | China | 75 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
Related articles
- The uses of Vanillyl butyl ether
- Vanillyl alcohol ether derivatives, specifically vanillyl butyl ether, have been proposed as an alternative, milder warming a....
- Dec 28,2023
View Latest Price from Vanillyl butyl ether manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-09-16 | Vanillyl butyl ether
82654-98-6
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
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2026-09-16 | Vanillyl butyl ether
82654-98-6
|
$66.00-99.00 | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | ||
 |
2026-09-07 | Vanillyl butyl ether
82654-98-6
|
1kg | 99%min | 20tons | HANGZHOU HAILAN CHEMICAL CO.,LTD. |
-
- Vanillyl butyl ether
82654-98-6
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Vanillyl butyl ether
82654-98-6
- $66.00-99.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Vanillyl butyl ether
82654-98-6
- $0.00
- 99%min
- HANGZHOU HAILAN CHEMICAL CO.,LTD.
