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BOC-TOTA

BOC-TOTA structure

CAS No.: 194920-62-2

Chemical Name:: BOC-TOTA

Synonyms: N-BOC-4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE;tert-Butyl (3-(2-(2-(3-aMinopropoxy)ethoxy)ethoxy)propyl)carbaMate;BOC-TOTA;CAS_194920-62-2;BOC-AMINO-PEG3-AMINE;N-Boc-C1-PEG3-C3-NH2;t-boc-N-amido-dPEG??-amine;t-BocNHCH2-PEG3-CH2CH2CH2NH2;t-boc-N-amido-dPEG??-amine (QBD-10225);BOC-1-AMINO-4,7,10-TRIOXA-13-TRIDECANAMINE

CBNumber:: CB8159917

Molecular Formula:: C15H32N2O5

Molecular Weight:: 320.42

MDL Number:: MFCD04973133

MOL File:: 194920-62-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-16 07:06:08

Product description	Number	Pack Size	Price
N-Boc-4,7,10-trioxa-1,13-tridecanediamine ≥95.0% (NT)	93113	1G	$212
N-Boc-4,7,10-trioxa-1,13-tridecanediamine	B6622	1G	$68
Boc-1-amino-4,7,10-trioxa-13-tridecanamine Asreported	265555	500mg	$375
Boc-1-amino-4,7,10-trioxa-13-tridecanamine Asreported	265555	1g	$644
Boc-1-amino-4,7,10-trioxa-13-tridecanamine Asreported	265555	2g	$911
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BOC-TOTA Properties

Boiling point	432.4±35.0 °C(Predicted)
Density	1.035 g/mL at 20 °C
storage temp.	2-8°C
solubility	Chloroform, Ethyl Acetate (Slightly)
pka	12.66±0.46(Predicted)
form	Oil
color	Colourless
InChI	1S/C15H32N2O5/c1-15(2,3)22-14(18)17-7-5-9-20-11-13-21-12-10-19-8-4-6-16/h4-13,16H2,1-3H3,(H,17,18)
InChIKey	WHHYAYNALHPDGJ-UHFFFAOYSA-N
SMILES	NCCCOCCOCCOCCCNC(OC(C)(C)C)=O
UNSPSC Code	12352116
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P280-P305+P351+P338-P321
PPE	Eyeshields, Gloves
WGK Germany	3
F	10-34
HS Code	2924190090
Storage Class	10 - Combustible liquids

BOC-TOTA price More Price(82)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	93113	N-Boc-4,7,10-trioxa-1,13-tridecanediamine ≥95.0% (NT)	194920-62-2	1G	$212	2026-04-30	Buy
TCI Chemical	B6622	N-Boc-4,7,10-trioxa-1,13-tridecanediamine	194920-62-2	1G	$68	2026-04-30	Buy
Usbiological	265555	Boc-1-amino-4,7,10-trioxa-13-tridecanamine Asreported	194920-62-2	500mg	$375	2026-06-03	Buy
Usbiological	265555	Boc-1-amino-4,7,10-trioxa-13-tridecanamine Asreported	194920-62-2	1g	$644	2026-06-03	Buy
Usbiological	265555	Boc-1-amino-4,7,10-trioxa-13-tridecanamine Asreported	194920-62-2	2g	$911	2026-06-03	Buy

Product number	Packaging	Price	Buy
93113	1G	$212	Buy
B6622	1G	$68	Buy
265555	500mg	$375	Buy
265555	1g	$644	Buy
265555	2g	$911	Buy

BOC-TOTA Chemical Properties,Uses,Production

Description

Boc-TOTA is a linker containing an amino group with a Boc-protected amino group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

tert-Butyl (3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)carbamate is used as a reactant in the synthesis of gallium-labeled PET imaging agents for CXCR4 for potential cancer diagnosis.

Uses

Protected linker.

reaction suitability

reagent type: cross-linking reagent

Synthesis

4246-51-9

24424-99-5

194920-62-2

GENERAL STEPS: A solution of di-tert-butyl dicarbonate (1.99 g, 9.12 mmol) in dichloromethane (55 mL + 5 mL of rinse solution) was slowly added dropwise through the addition funnel to a solution of 4,7,10-trioxo-1,13-tridecanediamine (20 mL, 91.2 mmol) in dichloromethane (100 mL) at 0°C. The reaction mixture was gradually warmed to room temperature and stirred for 3 hours. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature and stirring was continued for 3 hours. Upon completion of the reaction, the reaction was quenched with deionized water (100 mL). The organic and aqueous phases were separated, and the organic phase was washed sequentially with deionized water (3×50 mL) and saturated saline (50 mL), dried with anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure to afford N-BOC-4,7,10-trioxa-1,13-tridecanediamine (2.571 g, 88% yield) as a colorless liquid. Thin layer chromatography (TLC) analysis: Rf = 0.14 (Expanding agent: 10% methanol, 0.5% ammonia in dichloromethane solution).1H-NMR (CDCl3, 400 MHz) data: δ 5.10 (broad single peak, 1H), 3.51-3.64 (multiple peaks, 12H), 3.61 (single peak, 4H), 3.21 (multiple peaks, 2H), 2.79 (triple peak, J = 6.7 Hz, 1H), 1.77-1.68 (multiple peaks, 4H), 1.42 (single peak, 9H) ppm.

IC 50

PEGs

References

[1] Chemical Communications, 2010, vol. 46, # 39, p. 7403 - 7405
[2] Bioconjugate Chemistry, 2013, vol. 24, # 12, p. 2058 - 2066
[3] Journal of the American Chemical Society, 2000, vol. 122, # 11, p. 2663 - 2664
[4] Angewandte Chemie - International Edition, 2007, vol. 46, # 11, p. 1798 - 1802
[5] European Journal of Organic Chemistry, 2004, # 9, p. 1983 - 2001

BOC-TOTA Preparation Products And Raw materials

Raw materials

4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE Di-tert-butyl dicarbonate

Preparation Products

[3aS-(3aalpha,4beta,6aalpha)]-N-[3-[2-[2-(3-Aminopropoxy)ethoxy]ethoxy]propyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide mono(trifluoroacetate) Boc-TOTA-N3 6,9,12-Trioxa-2,16-diazaoctadecanoic acid, 18-chloro-17-oxo-, 1,1-dimethylethyl ester

BOC-TOTA Suppliers

Global( 117)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32998	60
Accela ChemBio Inc.	+1-858-6993322 +86-18019713315	info@accelachem.com	United States	21189	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
Fuxin Pharmaceutical	+86-021-021-50872116	contact@fuxinpharm.com	China	9976	58
Wuhan Borenpharm Co., Ltd	027-65563561 18717150066	3207347307@qq.com	CHINA	1238	58
XIAMEN SINOPEG BIOTECH CO., LTD.	+86-0592-7761068 15616186207	changaiwei@sinopeg.com	China	1133	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20000	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +8619957148339	market18@leapchem.com	China	24569	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38999	58
Henan Allgreen Chemical Co.,LTD	+86-37155567971 +86-13633837469	info@allgreenchem.com	China	5990	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
Fuxin Pharmaceutical	58
Wuhan Borenpharm Co., Ltd	58
XIAMEN SINOPEG BIOTECH CO., LTD.	58
Alfa Chemistry	58
HANGZHOU LEAP CHEM CO., LTD.	58
TargetMol Chemicals Inc.	58
Henan Allgreen Chemical Co.,LTD	58

View Lastest Price from BOC-TOTA manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-24	tert-butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate 194920-62-2		1g	98%	1g/bottle, 10g/bottle, 100g/bottle	XIAMEN SINOPEG BIOTECH CO., LTD.
	2026-07-15	N-Boc-C1-PEG3-C3-NH2 194920-62-2				10g	TargetMol Chemicals Inc.

tert-butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate
194920-62-2
98%
XIAMEN SINOPEG BIOTECH CO., LTD.

N-Boc-C1-PEG3-C3-NH2
194920-62-2
$0.00
TargetMol Chemicals Inc.

BOC-TOTA Spectrum

BOC-TOTA(194920-62-2)¹HNMR

194920-62-2(BOC-TOTA)Related Search:

Methyl sorbate Octa(OtBu)-Glu-OtBu tert-butyl (2S,4S)-4-hydroxypyrrolidine-2-carboxylate Tert-butyl N-(5-hydroxy-2,2-dimethylpentyl)carbamate Carbamic acid, (4-bromo-5-fluoro-2-methoxyphenyl)-, 1,1-dimethylethyl ester (9CI)

Carbamic acid, N-(5-hydroxy-4,4-dimethylpentyl)-, 1,1-dimethylethyl ester tert-butyl N-({5H,6H,7H,8H-imidazo[1,2-a]pyrimidin-2-yl}met hyl)carbamate TERT-BUTYL (5-CYANO-2,3-DIHYDRO-1H-INDEN-1-YL)CARBAMATE BOC-TOTA 4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE

17-Oxo-6,9,12-trioxa-2,16-diazaeicosanedioic acid 1-(1,1-dimethylethyl)ester

1of3

1-(T-BUTYLOXYCARBONYL-AMINO)-4,7,10-TRIOXA-13-TRIDECANAMINE 1-(TERT-BUTYLOXYCARBONYL-AMINO)-4,7,10-TRIOXA-13-TRIDECANAMINE 3-[2-(2-(3-(BOC-AMINO)PROPYLOXY)ETHOXY)ETHOXY]PROPYLAMINE BOC-TOTA BOC-1-AMINO-4,7,10-TRIOXA-13-TRIDECANAMINE N-Boc-4,7,10-trioxa-1,13-tridecanediamine >=95.0% (NT) tert-butyl N-[3-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]propyl]carbamate tert-Butyl (3-(2-(2-(3-aminopropoxy)ethoxy) 194920-62-2 CAS_194920-62-2 t-BocNHCH2-PEG3-CH2CH2CH2NH2 BOC-AMINO-PEG3-AMINE 6,9,12-Trioxa-2-azapentadecanoic acid, 15-amino-, 1,1-dimethylethyl ester t-boc-N-amido-dPEG??-amine N-Boc-C1-PEG3-C3-NH2 N-Boc-4,7,10-trioxa-1,13-tridecanediamine t-boc-N-amido-dPEG??-amine (QBD-10225) N-BOC-4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE tert-Butyl (3-(2-(2-(3-aMinopropoxy)ethoxy)ethoxy)propyl)carbaMate 194920-62-2 peg