4-Bromo-2-(trifluoromethyl)phenol
- CAS No.
- 50824-04-9
- Chemical Name:
- 4-Bromo-2-(trifluoromethyl)phenol
- Synonyms
- 5-Bromo-2-hydroxyBenzotrifluoride;4-BROMO-2-(TRIFLUOROMETHYL)PHENOL;4-BroMo-2-(trifluoroMethyl)phenol4;4-BROMO-2-(TRIFLUOROMETHYL)BENZENOL;4-Beromo-2-(trifluoromethyl)benzenol;Phenol, 4-bromo-2-(trifluoromethyl)-;4-Bromo-2-(trifluoromethyl)phenol >5-Bromo-2-hydroxybenzotrifluoride 99%;4-broMo -2-three fluorineMethyl phenol;4-Bromo-2-(trifluoromethyl)phenol, 4-Bromo-alpha,alpha,alpha-trifluoro-o-cresol
- CBNumber:
- CB8179670
- Molecular Formula:
- C7H4BrF3O
- Molecular Weight:
- 241.01
- MDL Number:
- MFCD05668981
- MOL File:
- 50824-04-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 83-85° |
|---|---|
| Boiling point | 203.4±35.0 °C(Predicted) |
| Density | 1.752±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Crystalline Powder |
| pka | 7.41±0.43(Predicted) |
| color | White |
| InChI | InChI=1S/C7H4BrF3O/c8-4-1-2-6(12)5(3-4)7(9,10)11/h1-3,12H |
| InChIKey | PDPGERGWEOJVDC-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=C(Br)C=C1C(F)(F)F |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P280h-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2908190090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
4-Bromo-2-(trifluoromethyl)phenol price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | KOB0023 | 4-Bromo-2-(trifluoromethyl)benzenol | 50824-04-9 | 1 g | $191 | 2026-04-30 | Buy |
| TCI Chemical | B4493 | 4-Bromo-2-(trifluoromethyl)phenol >97.0%(GC) | 50824-04-9 | 5g | $63 | 2026-04-30 | Buy |
| TCI Chemical | B4493 | 4-Bromo-2-(trifluoromethyl)phenol >97.0%(GC) | 50824-04-9 | 25g | $250 | 2026-04-30 | Buy |
| Biosynth | FB67200 | 4-Bromo-2-(trifluoromethyl)phenol | 50824-04-9 | 0.025kg | $150 | 2026-06-04 | Buy |
| Apolloscientific | PC1794 | 5-Bromo-2-hydroxybenzotrifluoride 98% | 50824-04-9 | 250mg | $21 | 2026-06-04 | Buy |
4-Bromo-2-(trifluoromethyl)phenol Chemical Properties, Uses, Production
Chemical Properties
light yellow crystalline
Synthesis
444-30-4
50824-04-9
General procedure for the synthesis of 4-bromo-2-trifluoromethylphenol from o-trifluoromethylphenol: o-trifluoromethylphenol (6.0 g, 37 mmol) was dissolved in trifluoroacetic acid (30 ml), then bromine (5.91 g, 37 mmol) was added slowly and dropwise at room temperature. The reaction mixture was stirred for 2 hours. After completion of the reaction, ethyl acetate (200 ml) was added for extraction. The organic phase was washed sequentially with brine (50 mL x 2), saturated sodium carbonate solution (50 mL x 2) and brine (50 ml), and then dried with anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give 4-bromo-2-trifluoromethylphenol (gray solid, 8.9 g, yield: 100%).
References
[1] Patent: CN105732602, 2016, A. Location in patent: Paragraph 0094; 0096; 0097; 0098; 0099
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 5, p. 2107 - 2120
[3] Patent: WO2014/209034, 2014, A1. Location in patent: Paragraph 541; 542; 543
[4] Synthesis, 1999, # 11, p. 1878 - 1880
[5] Bulletin of the Chemical Society of Japan, 2004, vol. 77, # 12, p. 2257 - 2263
4-Bromo-2-(trifluoromethyl)phenol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Latest Price from 4-Bromo-2-(trifluoromethyl)phenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | 4-Bromo-2-(trifluoromethyl)phenol
50824-04-9
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 4-Bromo-2-(trifluoromethyl)phenol
50824-04-9
- $1.00
- 99%
- Career Henan Chemical Co
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