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2-Bromo-5-trifluoromethylphenol

2-Bromo-5-trifluoromethylphenol Structure
2-Bromo-5-trifluoromethylphenol structure
CAS No.
402-05-1
Chemical Name:
2-Bromo-5-trifluoromethylphenol
Synonyms
2-Bromo-3-(trifluoromethyl)phenol;2-Bromo-5-trifluoromethylphenol;5-BROMO-3-TRIFLUOROMETHYLPHENOL;5-Bromo-2-Trifluoromethyl-Phenol;Phenol, 2-bromo-5-(trifluoromethyl)-;5-BROMO-2-TRIFLUOROMETHYLPHENOL,SPECIFICATION: >99.0%(GC FID)
CBNumber:
CB4855015
Molecular Formula:
C7H4BrF3O
Molecular Weight:
241.01
MDL Number:
MFCD09261190
MOL File:
402-05-1.mol
MSDS File:
SDS
Last updated:2026-05-28 01:19:29
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2-Bromo-5-trifluoromethylphenol Properties

Melting point 22-23°
Boiling point 56.0-57.5 °C(Press: 3.5-4.0 Torr)
Density 1.752
storage temp. Inert atmosphere,Room Temperature
form Liquid
pka 7.43±0.10(Predicted)
color Pale brown

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Warning
Hazard statements  H302-H312-H314-H318-H332
Precautionary statements  P260h-P301+P330+P331-P303+P361+P353-P305+P351+P338-P405-P501a
RIDADR  UN1760
HazardClass  IRRITANT
HazardClass  8
HS Code  2905599890
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
3 0

2-Bromo-5-trifluoromethylphenol price More Price(52)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC499002 2-Bromo-5-(trifluoromethyl)phenol 99% 402-05-1 1g $21 2026-06-04 Buy
Apolloscientific PC499002 2-Bromo-5-(trifluoromethyl)phenol 99% 402-05-1 5g $24 2026-06-04 Buy
Apolloscientific PC499002 2-Bromo-5-(trifluoromethyl)phenol 99% 402-05-1 25g $81 2026-06-04 Buy
Apolloscientific PC499002 2-Bromo-5-(trifluoromethyl)phenol 99% 402-05-1 100g $315 2026-06-04 Buy
Apolloscientific PC499002 2-Bromo-5-(trifluoromethyl)phenol 99% 402-05-1 500g $1559 2026-06-04 Buy
Product number Packaging Price Buy
PC499002 1g $21 Buy
PC499002 5g $24 Buy
PC499002 25g $81 Buy
PC499002 100g $315 Buy
PC499002 500g $1559 Buy

2-Bromo-5-trifluoromethylphenol Chemical Properties,Uses,Production

Chemical Properties

light brown liquid

Uses

2-Bromo-3-(trifluoromethyl)phenol is used as a reactant in the synthesis of benzimidazolone and benzothiazolone compounds as AMPA receptor modulators.

Synthesis

3-Trifluoromethylphenol

98-17-9

2-Bromo-5-trifluoromethylphenol

402-05-1

General procedure for the synthesis of 2-bromo-5-trifluoromethylphenol from 3-trifluoromethylphenol: To a stirred solution of 61.65 g (0.38 mol) of 3-trifluoromethylphenol dissolved in 240 ml of carbon disulfide, 19.6 ml (0.38 mol) of bromine was slowly added dropwise. The reaction mixture was stirred continuously at room temperature for about 18 hours. Subsequently, the reaction solution was partitioned between 200 ml of dichloromethane and 100 ml of water. The organic phase was separated, washed with 20 mL of saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using dichloromethane containing 40% hexane as eluent. The eluate containing the target product was collected and concentrated under reduced pressure to give 48.8 g (53% yield) of 2-bromo-5-trifluoromethylphenol as a yellow oil. Ion spray mass spectrometry (MS) analysis showed m/e = 239,241 (M + 1).

References

[1] Journal of the American Chemical Society, 1951, vol. 73, p. 1325
[2] Journal of Organic Chemistry, 1951, vol. 16, p. 586,606
[3] Patent: US6638936, 2003, B1

2-Bromo-5-trifluoromethylphenol Preparation Products And Raw materials

Raw materials

3-Trifluoromethylphenol Carbon disulfide Hexane

Preparation Products

2-Bromo-5-trifluoromethylphenol Suppliers

Global( 143)Suppliers
Supplier Tel Email Country ProdList Advantage
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Nanjing Chemrui Pharmtech Co., Ltd. 86-25-58849758 13851795789 sales@chemrui.com China 47 62
Supplier Advantage
PharmaBlock Sciences (Nanjing),Inc. 55
Alfa Aesar 84
Accela ChemBio Co.,Ltd. 64
Shanghai Longsheng chemical Co.,Ltd. 59
Shanghai Harvest Chemical Industrial Co., Ltd. 64
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shandong Xiya Chemical Co., Ltd 57
Syntechem Co.,Ltd 57
Nanjing Chemrui Pharmtech Co., Ltd. 62

View Lastest Price from 2-Bromo-5-trifluoromethylphenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromo-5-trifluoromethylphenol pictures 2023-12-04 2-Bromo-5-trifluoromethylphenol
402-05-1
 98% 100kg Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
2-Bromo-5-trifluoromethylphenol pictures 2019-12-31 2-Bromo-5-trifluoromethylphenol
402-05-1
 $1.00 1KG 99% 200kg Career Henan Chemical Co

2-Bromo-5-trifluoromethylphenol Spectrum

2-Bromo-5-trifluoromethylphenol(402-05-1)1HNMR2-Bromo-5-trifluoromethylphenol(402-05-1)19FNMR

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2-Bromo-5-trifluoromethylphenol 5-Bromo-2-Trifluoromethyl-Phenol 5-BROMO-3-TRIFLUOROMETHYLPHENOL 5-BROMO-2-TRIFLUOROMETHYLPHENOL,SPECIFICATION: >99.0%(GC FID) Phenol, 2-bromo-5-(trifluoromethyl)- 2-Bromo-3-(trifluoromethyl)phenol 402-05-1 C7H4OBrF3 Fluorine series