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2-Bromo-5-trifluoromethylphenol

2-Bromo-5-trifluoromethylphenol Structure
2-Bromo-5-trifluoromethylphenol structure
CAS No.
402-05-1
Chemical Name:
2-Bromo-5-trifluoromethylphenol
Synonyms
2-Bromo-5-trifluoromethylphenol;5-BROMO-3-TRIFLUOROMETHYLPHENOL;5-Bromo-2-Trifluoromethyl-Phenol;2-Bromo-3-(trifluoromethyl)phenol;Phenol, 2-bromo-5-(trifluoromethyl)-;5-BROMO-2-TRIFLUOROMETHYLPHENOL,SPECIFICATION: >99.0%(GC FID)
CBNumber:
CB4855015
Molecular Formula:
C7H4BrF3O
Molecular Weight:
241.01
MDL Number:
MFCD09261190
MOL File:
402-05-1.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:48
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2-Bromo-5-trifluoromethylphenol Properties

Boiling point 56.0-57.5 °C(Press: 3.5-4.0 Torr)
Density 1.752
storage temp. Inert atmosphere,Room Temperature
form Liquid
pka 7.43±0.10(Predicted)
color Pale brown

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07
Signal word  Warning
Hazard statements  H302-H312-H314-H318-H332
Precautionary statements  P260h-P301+P330+P331-P303+P361+P353-P305+P351+P338-P405-P501a
HazardClass  IRRITANT
HazardClass  8
HS Code  2905599890
NFPA 704
1
3 0

2-Bromo-5-trifluoromethylphenol price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B695955 2-Bromo-5-trifluoromethylphenol 402-05-1 1g $75 2021-12-16 Buy
TRC B695955 2-Bromo-5-trifluoromethylphenol 402-05-1 250mg $55 2021-12-16 Buy
Biosynth Carbosynth FB64425 2-Bromo-5-(trifluoromethyl)phenol 402-05-1 5G $200 2021-12-16 Buy
American Custom Chemicals Corporation HCH0353134 2-BROMO-5-TRIFLUOROMETHYLPHENOL 95.00% 402-05-1 5MG $495.19 2021-12-16 Buy
Biosynth Carbosynth FB64425 2-Bromo-5-(trifluoromethyl)phenol 402-05-1 25g $500 2021-12-16 Buy
Product number Packaging Price Buy
B695955 1g $75 Buy
B695955 250mg $55 Buy
FB64425 5G $200 Buy
HCH0353134 5MG $495.19 Buy
FB64425 25g $500 Buy

2-Bromo-5-trifluoromethylphenol Chemical Properties,Uses,Production

Chemical Properties

light brown liquid

Uses

2-Bromo-3-(trifluoromethyl)phenol is used as a reactant in the synthesis of benzimidazolone and benzothiazolone compounds as AMPA receptor modulators.

Synthesis

3-Trifluoromethylphenol

98-17-9

2-Bromo-5-trifluoromethylphenol

402-05-1

General procedure for the synthesis of 2-bromo-5-trifluoromethylphenol from 3-trifluoromethylphenol: To a stirred solution of 61.65 g (0.38 mol) of 3-trifluoromethylphenol dissolved in 240 ml of carbon disulfide, 19.6 ml (0.38 mol) of bromine was slowly added dropwise. The reaction mixture was stirred continuously at room temperature for about 18 hours. Subsequently, the reaction solution was partitioned between 200 ml of dichloromethane and 100 ml of water. The organic phase was separated, washed with 20 mL of saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using dichloromethane containing 40% hexane as eluent. The eluate containing the target product was collected and concentrated under reduced pressure to give 48.8 g (53% yield) of 2-bromo-5-trifluoromethylphenol as a yellow oil. Ion spray mass spectrometry (MS) analysis showed m/e = 239,241 (M + 1).

References

[1] Journal of the American Chemical Society, 1951, vol. 73, p. 1325
[2] Journal of Organic Chemistry, 1951, vol. 16, p. 586,606
[3] Patent: US6638936, 2003, B1

2-Bromo-5-trifluoromethylphenol Preparation Products And Raw materials

Raw materials

3-Trifluoromethylphenol Carbon disulfide Hexane

Preparation Products

2-Bromo-5-trifluoromethylphenol Suppliers

Global( 140)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29734 60
Fluoropharm Co., Ltd. 		+86-0571-85586753 +86-13336034509 sales@fluoropharm.com China 1445 60
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10406 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 52513593@qq.com CHINA 2972 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29801 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10035 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9636 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Fluoropharm Co., Ltd. 		60
Shenzhen Nexconn Pharmatechs Ltd 		58
Nanjing Dolon Biotechnology Co.,Ltd. 		58
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Fuxin Pharmaceutical 		58
Antai Fine Chemical Technology Co.,Limited 		58

View Lastest Price from 2-Bromo-5-trifluoromethylphenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromo-5-trifluoromethylphenol pictures 2023-12-04 2-Bromo-5-trifluoromethylphenol
402-05-1
 US $0.00-0.00 / kg 0.10000000149011612kg 98% 100kg Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
2-Bromo-5-trifluoromethylphenol pictures 2019-12-31 2-Bromo-5-trifluoromethylphenol
402-05-1
 US $1.00 / KG 1KG 99% 200kg Career Henan Chemical Co

2-Bromo-5-trifluoromethylphenol Spectrum

2-Bromo-5-trifluoromethylphenol(402-05-1)1HNMR2-Bromo-5-trifluoromethylphenol(402-05-1)19FNMR

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2-Bromo-5-trifluoromethylphenol 2-Bromo-3-(trifluoromethyl)phenol 5-Bromo-2-Trifluoromethyl-Phenol 5-BROMO-3-TRIFLUOROMETHYLPHENOL 5-BROMO-2-TRIFLUOROMETHYLPHENOL,SPECIFICATION: >99.0%(GC FID) Phenol, 2-bromo-5-(trifluoromethyl)- 402-05-1 C7H4OBrF3 Fluorine series