Tryptamine
- CAS No.
- 61-54-1
- Chemical Name:
- Tryptamine
- Synonyms
- L-TRYPTAMINE;TRIPTAMINE;1H-INDOLE-3-ETHANAMINE;TRYPTAMINE CAS 61-54-1;2-(1H-INDOL-3-YL)ETHANAMINE;2-(1H-indol-3-yl)ethan-1-aMine hydrochloride;Tryptamin;3-(2-AMINOETHYL)INDOLE;b mk-2;ryptamine
- CBNumber:
- CB8192006
- Molecular Formula:
- C10H12N2
- Molecular Weight:
- 160.22
- MDL Number:
- MFCD00005661
- MOL File:
- 61-54-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 113-116 °C (lit.) |
|---|---|
| Boiling point | 137 °C/0.15 mmHg (lit.) |
| Density | 0.9787 (rough estimate) |
| refractive index | 1.6210 (estimate) |
| Flash point | 185 °C |
| storage temp. | 2-8°C |
| solubility | water: soluble1g/L at 20°C |
| pka | 10.2(at 25℃) |
| form | crystalline |
| color | white |
| PH | 11.07 (10g/l, H2O, 24.7℃) |
| Water Solubility | negligible |
| Sensitive | Air Sensitive |
| Merck | 14,9796 |
| BRN | 125513 |
| Major Application |
cleaning products cosmetics food and beverages personal care |
| InChI | 1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2 |
| InChIKey | APJYDQYYACXCRM-UHFFFAOYSA-N |
| SMILES | NCCc1c[nH]c2ccccc12 |
| CAS DataBase Reference | 61-54-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 422ZU9N5TV |
| NIST Chemistry Reference | 1H-Indole-3-ethanamine(61-54-1) |
| EPA Substance Registry System | Tryptamine (61-54-1) |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H317-H318 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38-41-37/38-22 | |||||||||
| Safety Statements | 24/25-36/37/39-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NL4020000 | |||||||||
| F | 8-23 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 28259080 | |||||||||
| HS Code | 29339990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Sens. 1A |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Tryptamine price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 193747 | Tryptamine ≥97% | 61-54-1 | 10g | $49.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | 76706 | Tryptamine analytical standard | 61-54-1 | 100MG | $81.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 193747 | Tryptamine ≥97% | 61-54-1 | 50g | $169 | 2026-04-30 | Buy |
| TCI Chemical | T0890 | Tryptamine >98.0%(HPLC)(T) | 61-54-1 | 25g | $56 | 2026-04-30 | Buy |
| Cayman Chemical | 33682 | Tryptamine ≥98% | 61-54-1 | 25mg | $36 | 2026-04-30 | Buy |
Tryptamine Chemical Properties, Uses, Production
Description
Tryptamine is a monoamine alkaloid that can be synthesized by decarboxylation of the amino acid tryptophan. Notably, tryptamine can be found in fungi, plants, Amphibia, animals, and microbes.
Tryptamine has an indole ring structure and a fused double ring that is composed of a benzene ring and a pyrrole ring, linked to an amino group by 2-carbon side chain. The indole ring is the vital nucleus of many complex natural products that have significance in drug discovery as well as some synthetic and non-synthetic drugs that are based on tryptamine skeleton.
The chemical’s distinct structure is an approximation to the neurotransmitter serotonin as well-known drugs and hallucinogens. Tryptamine’s significance as psychedelic drugs, neuromodulator, and neurotransmitter is well understood due to its presence in mammalian brain in small amounts.
Applications
Analogs of tryptamine that are typically produced by its synthetic modification play a significant role in individuals due to the introduction of functionalities that are biologically active in its nucleus that may cause changes in the mental and physical status of the human brain.
Substitutions on the indole ring at nitrogen and C-2 of its side chain produce numerous neuroactive compounds ranging from anti-migraine drugs to toxic substances, such as rizatriptan, sumatriptan, and zolmitriptan. A small amount of tryptamine is required due to its fatalities and intoxication for several reasons.
Plants Containing Tryptamine
In plants, tryptamine in small amounts acts as a promising phase to the plant hormone indole-3-acetic acid in one biosynthetic pathway. N, N-dimethyltryptamine (DMT) is a tryptamine derivative that is an active constituent for the hallucinogenic effect of brew known as the “vine of the souls.” Indigenous Amazonian tribes have traditionally used the drink for therapeutic purposes for effective treatment of some physical maladies and abuse disorders. Magic mushrooms are the most common fungi that contain tryptamine derivatives.
Pharmacology
Serotonin (5-hydroxytryptamine, 5-HT), which is a natural derivative of tryptamine is a significant signaling hormone that helps in the modulation and regulation of numerous processes within the central nervous system, for instance, cognition, sleep, temperature regulation, memory, and behavior. The mammalian brain contains small traces of tryptamine, which generally act as a modulator or neurotransmitter by releasing serotonin agents. It is also an enhancer of serotonergic activity. Only one minute is required for tryptamine to produce psychotropic phenomena when used recreationally. It has been associated with fatalities and intoxications for multiple reasons including low toxic concentrations.
Description
Tryptamine is an indole alkaloid and intermediate in the biosynthesis of serotonin and the phytohormone melatonin in plants. It increases the levels of the terpenoid indole alkaloids ajmalicine, strictosidine, and catharanthine in cultures of C. roseus. Tryptamine is also a product of tryptophan metabolism in mammals. Tryptamine derivatives have been synthetically produced as hallucinogenic drugs of abuse that act on the serotonergic system.
Chemical Properties
Tryptamine is a biogenic imine derived from the decarboxylation of tryptophan. It is a white to orange crystalline Powder, melting point 118°C (decomposition at 145-146°C). Soluble in ethanol and acetone, almost insoluble in ether, benzene, chloroform and water.
Uses
Tryptamine is a monoamine alkaloid found in plants. Tryptamine is commonly used in the preparation of biologically active compounds such as neurotransmitters and psychedelics.
Definition
ChEBI: Tryptamine is an aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position. It has a role as a human metabolite, a plant metabolite and a mouse metabolite. It is an aminoalkylindole, an indole alkaloid, an aralkylamino compound and a member of tryptamines. It is a conjugate base of a tryptaminium.
Preparation
Tryptamine, a monoamine alkaloid containing an indole ring structure is derived by the decarboxylation of amino acid tryptophan.
The synthesis of tryptamines is typically conducted following a classic route starting with a Mannich reaction of an indole heterocycle, followed by quaternization of the amine, nucleophilic substitution with highly toxic cyanide and final reduction.
General Description
Tryptamines which are usually found in plants, fungi, animals, etc. are categorized under the monoamine alkaloids class of compounds.
Biochem/physiol Actions
Vasoactive; may have a neuromodulator function; biogenic amine formed from the decarboxylation of tryptophan by L-aromatic amino acid decarboxylase.
Purification Methods
Crystallise tryptamine from *benzene, Et2O (m 114o) or pet ether (m 118o). It has UV: 222n 276, 282 and 291nm (EtOH) and max 226, 275, 281 and 290nm (HCl). [Beilstein 22 II 346, 22 III/IV 4319, 22/10 V 45.]
References
[1] ANA MARGARIDA ARAúJO. The hallucinogenic world of tryptamines: an updated review[J]. Archives of Toxicology, 2015, 89 8: 1151-1173. DOI: 10.1007/s00204-015-1513-x
[2] ARNAO M B. Phytomelatonin: Discovery, Content, and Role in Plants[C]. 2014: 0. DOI: 10.1155/2014/815769
[3] JIBIAO FAN. Melatonin: A Multifunctional Factor in Plants.[J]. International Journal of Molecular Sciences, 2018, 19 5. DOI: 10.3390/ijms19051528
[4] LORENA ALMAGRO Maria A P Francisco Fernández Pérez. Indole alkaloids from Catharanthus roseus: bioproduction and their effect on human health.[J]. Molecules, 2015, 20 2: 2973-3000. DOI: 10.3390/molecules20022973
[5] LAURA CRISTINA BERUMEN. Serotonin receptors in hippocampus.[J]. The Scientific World Journal, 2012: 823493. DOI: 10.1100/2012/823493
Tryptamine Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Qibu New Material Technology Co., Ltd. | 0715-8890696 18062324989 | 2284979616@qq.com | China | 519 | 58 |
| Baoding Bink New Materials Co., Ltd. | 18531123677 | faithe@yan-xi.com | China | 277 | 58 |
| Wuxi Jingyao Bio-Technology Co., Ltd. | 88770633 13961738808 | jingyaobiotech@126.com | China | 389 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
Related articles
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View Latest Price from Tryptamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | Tryptamine
61-54-1
|
$159.00 | 1kg | 0.98 | 100kg | Shanghai UCHEM Inc. | |
 |
2026-09-16 | Tryptamine
61-54-1
|
$10.00 | 1ASSAYS | 99% | 10 ton | RongNa Biotechnology Co.,Ltd | |
 |
2026-09-02 | Tryptamine
61-54-1
|
$1.00-6.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd |
-
- Tryptamine
61-54-1
- $159.00
- 0.98
- Shanghai UCHEM Inc.
-
- Tryptamine
61-54-1
- $10.00
- 99%
- RongNa Biotechnology Co.,Ltd
-
- Tryptamine
61-54-1
- $1.00-6.00
- 99%
- Henan Fengda Chemical Co., Ltd
