Tryptophol
- CAS No.
- 526-55-6
- Chemical Name:
- Tryptophol
- Synonyms
- 2-(1H-INDOL-3-YL)ETHAN-1-OL;INDOLE-3-ETHANOL;IEA;3-(2-HYDROXYETHYL)INDOLE;3-INDOLEETHANOL;Indoleethanol;B-3-INDOLYLETHANOL;BETA-3-INDOLYLETHANOL;DK803;NSC 3884
- CBNumber:
- CB0782869
- Molecular Formula:
- C10H11NO
- Molecular Weight:
- 161.2
- MDL Number:
- MFCD00005659
- MOL File:
- 526-55-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 56-59 °C(lit.) |
|---|---|
| Boiling point | 174 °C (2.02527 mmHg) |
| Density | 1.0840 (rough estimate) |
| refractive index | 1.5200 (estimate) |
| Flash point | 255 °C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | methanol: 0.1 g/mL, clear |
| pka | 15.16±0.10(Predicted) |
| form | Crystalline Mass, Crystals, Flakes or Powder |
| color | Off-white to brown |
| Water Solubility | 10 g/L (20 ºC) |
| Merck | 14,9798 |
| BRN | 125553 |
| InChI | 1S/C10H11NO/c12-6-5-8-7-11-10-4-2-1-3-9(8)10/h1-4,7,11-12H,5-6H2 |
| InChIKey | MBBOMCVGYCRMEA-UHFFFAOYSA-N |
| SMILES | OCCc1c[nH]c2ccccc12 |
| LogP | 1.280 (est) |
| CAS DataBase Reference | 526-55-6(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 5809LZ7G1U |
| NIST Chemistry Reference | 1H-indole-3-ethanol(526-55-6) |
| EPA Substance Registry System | 1H-Indole-3-ethanol (526-55-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KL3685000 | |||||||||
| F | 8 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29339990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Toxicity | LD50 intraperitoneal in mouse: 351mg/kg | |||||||||
| NFPA 704 |
|
Tryptophol price More Price(82)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T90301 | 3-(2-Hydroxyethyl)indole 97% | 526-55-6 | 5g | $113 | 2026-04-30 | Buy |
| TCI Chemical | I0030 | 3-Indoleethanol >98.0%(GC) | 526-55-6 | 1g | $41 | 2026-04-30 | Buy |
| TCI Chemical | I0030 | 3-Indoleethanol >98.0%(GC) | 526-55-6 | 5g | $118 | 2026-04-30 | Buy |
| Cayman Chemical | 28404 | Tryptophol ≥98% | 526-55-6 | 1g | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 28404 | Tryptophol ≥98% | 526-55-6 | 5g | $95 | 2026-04-30 | Buy |
Tryptophol Chemical Properties,Uses,Production
Chemical Properties
3-(2-Hydroxyethyl)indole [526-55-6], tryptophol, C10H11NO, Mr 161.20, mp 59 ℃, bp 174 ℃, (2 kPa) forms colorless prisms or flakes that are readily soluble in methanol, ethanol, diethyl ether, chloroform, and acetone, soluble in benzene, and slightly soluble in water. It is produced by reacting methyl-1H-indole-3-acetate with lithium aluminum hydride, or through reduction of methyl-1H-indole-3-glyoxylate with sodium borohydride. The antihypertensive Indoramin is produced from tryptophol.
Uses
Tryptophol is a metabolite formed in the liver after disulfiram treatment that induces sleep in humans. It is also a secondary product of alcoholic fermentation.
Uses
Reactant for preparation of:
- Inhibitors of the C-terminal domain of RNA polymerase II and their antitumor activities
- Anti-HIV-1 agents
- Inhibitors of Protein-Protein Interactions
- Partial agonists of the serotonin 5-HT1A receptor
- Growth hormone secretagogues
- Vascular endothelial growth factor (VEGF) inhibitors
- A2B adenosine receptor ligands
- Potential detoxification inhibitors of the crucifer phytoalexin brassinin
- Inhibitors of interleukine 6
- Dual binding site acetylcholinesterase inhibitors
Definition
ChEBI: An indolyl alcohol that is ethanol substituted by a 1H-indol-3-yl group at position 2.
Synthesis Reference(s)
Canadian Journal of Chemistry, 42, p. 485, 1964 DOI: 10.1139/v64-070
Purification Methods
Crystallise it from diethyl ether/pet ether, *C6H6, *C6H6/pet ether. The picrate has m 100-101o (from *C6H6). [Beilstein 21 I 218, 21 II 49, 21 III/IV 788, 21/3 V 61.]
Tryptophol Preparation Products And Raw materials
Raw materials
1of4
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangxi Kingnord Industrial Limited | 0791-86493591 | jeff@kingnord.com | China | 43 | 57 |
| SHENZHEN REISCH BIOTECH CO., LTD | 0755-0755-28609002 15112530219 | 1179151648@qq.com | China | 236 | 58 |
| Jiujiang Huayao Biotechnology Co., Ltd. | 13970278471 15779253386 | 2436843764@qq.com | China | 101 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Lastest Price from Tryptophol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-08 | 2-(1H-Indol-3-yl)ethan-1-ol
526-55-6
|
$29.00 | 99.85% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-03-20 | Tryptophol
526-55-6
|
$25.00 | 100ASSAYS | 99.5% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-06-20 | Tryptophol
526-55-6
|
$50.00 | 1kg | 0.99 | 10000 | Hebei Yanxi Chemical Co., Ltd. |
-
- 2-(1H-Indol-3-yl)ethan-1-ol
526-55-6
- $29.00
- 99.85%
- TargetMol Chemicals Inc.
-
- Tryptophol
526-55-6
- $25.00
- 99.5%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Tryptophol
526-55-6
- $50.00
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
