(S)-5-Hydroxy-piperidin-2-one
- CAS No.
- 24211-54-9
- Chemical Name:
- (S)-5-Hydroxy-piperidin-2-one
- Synonyms
- RARECHEM AK ML 0202;(S)-5-Hydroxy-2-piperidone;(S)-5-Hydroxy-2-piperidinone;(S)-5-HYDROXY-PIPERIDIN-2-ON;(S)-5-Hydroxy-piperidin-2-one;(5S)-5-Hydroxy-piperidin-2-one;2-Piperidinone, 5-hydroxy-, (5S)-;(-)-(5S)-5-hydroxy-piperidin-2-one;(5S)-5-hydroxypiperidin-2-one - [H85866]
- CBNumber:
- CB8205483
- Molecular Formula:
- C5H9NO2
- Molecular Weight:
- 115.13
- MDL Number:
- MFCD06202374
- MOL File:
- 24211-54-9.mol
- MSDS File:
- SDS
| Melting point | 123-124℃ (methanol ethyl ether ) |
|---|---|
| Boiling point | 352.3±35.0 °C(Predicted) |
| Density | 1.199±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 14.21±0.20(Predicted) |
| Appearance | Off-white to light brown Solid |
| InChI | InChI=1S/C5H9NO2/c7-4-1-2-5(8)6-3-4/h4,7H,1-3H2,(H,6,8)/t4-/m0/s1 |
| InChIKey | GPRZVNYVEZZOKH-BYPYZUCNSA-N |
| SMILES | N1C[C@@H](O)CCC1=O |
(S)-5-Hydroxy-piperidin-2-one price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 62217 | (S)-5-HYDROXY-2-PIPERIDINONE 95% | 24211-54-9 | 0.25G | $43 | 2026-04-30 | Buy |
| AstaTech | 62217 | (S)-5-HYDROXY-2-PIPERIDINONE 95% | 24211-54-9 | 1G | $119 | 2026-04-30 | Buy |
| AstaTech | 62217 | (S)-5-HYDROXY-2-PIPERIDINONE 95% | 24211-54-9 | 5G | $579 | 2026-04-30 | Buy |
| Matrix Scientific | 313358 | (S)-5-Hydroxypiperidin-2-one | 24211-54-9 | 1.00g | $71 | 2026-05-19 | Buy |
| Matrix Scientific | 313358 | (S)-5-Hydroxypiperidin-2-one | 24211-54-9 | 5.00g | $337 | 2026-05-19 | Buy |
(S)-5-Hydroxy-piperidin-2-one Chemical Properties, Uses, Production
Uses
(5S)-5-Hydroxy-2-piperidinone is used in the enantioselective synthesis of peptides containing cyclopropane pipecolic acid, which can be useful as proline mimetics for probing protein-ligand interactions and generating novel bioactive compounds.
Synthesis
24211-53-8
24211-54-9
The general procedure for the synthesis of (S)-5-hydroxypiperidin-2-one from the compound (CAS:24211-53-8) was as follows: azide 13 (1.5 g, 10.62 mmol) was dissolved in anhydrous methanol and 20% Pd(OH)2 (0.037 g, 0.53 mmol) was added. The reaction mixture was stirred at 25°C for 24 h under hydrogen (1 atm) atmosphere. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated under reduced pressure to afford the crude product (S)-5-hydroxypiperidin-2-one. The crude product was purified by column chromatography using ethyl acetate and methanol (9:1, v/v) as eluent to finally obtain pure (S)-5-hydroxypiperidin-2-one 14 (1.19 g, 98% yield).
References
[1] Synthetic Communications, 2015, vol. 45, # 13, p. 1559 - 1565
[2] Tetrahedron, 1995, vol. 51, # 21, p. 5935 - 5950
[3] Tetrahedron Letters, 2005, vol. 46, # 8, p. 1247 - 1249
[4] Synthesis, 1986, vol. NO. 3, p. 232 - 233
[5] Journal of Organic Chemistry, 1985, vol. 50, # 6, p. 896 - 899
(S)-5-Hydroxy-piperidin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Cantotech Chemicals, Ltd. | 86-0755-86635001 | cantotech@126.com | China | 4554 | 55 |
| Chengdu Firster Pharmaceutical Co., Ltd. | 028-87078428 028-87074958 | chengzhenyong@cdfirster.com | China | 2580 | 60 |
| Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd. | 19943855286 | 94644163@qq.com | China | 1934 | 56 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16674 | 50 |
| Chizhou Kailong Import and Export Trade Co., Ltd. | xg01_gj@163.com | China | 9413 | 50 | |
| Hangzhou Milestone Pharmtech Co., Ltd. | 0571-82896630 18969958410 | sales_hz@milestonepharmtech.com | China | 4908 | 55 |
| SanoChem (Chengdu) Tech. Co., Ltd. | 28-87999436 02887999436 | sales@sano-chem.com | China | 3792 | 55 |
| NovoChemy Ltd. | 86-(0)21-31261262 373522135 | sales@novochemy.com | China | 6491 | 58 |
View Latest Price from (S)-5-Hydroxy-piperidin-2-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | (S)-5-HYDROXY-PIPERIDIN-2-ONE
24211-54-9
|
$5.50 | 1KG | 98%min | 1kg-100kg | Career Henan Chemical Co |
-
- (S)-5-HYDROXY-PIPERIDIN-2-ONE
24211-54-9
- $5.50
- 98%min
- Career Henan Chemical Co
