S-(+)-Methoprene
- CAS No.
- 65733-16-6
- Chemical Name:
- S-(+)-Methoprene
- Synonyms
- S-METHOPRENE;S-Methoprene @100 μg/mL in Methanol;(2E,4E,7S-)-11-Methoxy-3,7,11-trimethyl-2,4-dodecadienoic acid isopropyl ester;(7S)-Form;D-Methoprene;7S-Methoprene;S-Imidacloprid;S-Methoxyprene;Flea killer plus;S-(+)-Methoprene
- CBNumber:
- CB8214823
- Molecular Formula:
- C19H34O3
- Molecular Weight:
- 310.47
- MDL Number:
- MFCD00867612
- MOL File:
- 65733-16-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 385.7±25.0 °C(Predicted) |
|---|---|
| Density | 0.913±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 20 mg/ml,Ethanol: 10 mg/ml |
| form | A neat oil |
| color | Colorless to light yellow |
| Henry's Law Constant | 1.5×100 mol/(m3Pa) at 25℃, Ebert et al. (2023) |
| Stability | Light Sensitive |
| InChI | InChI=1S/C19H34O3/c1-15(2)22-18(20)14-17(4)11-8-10-16(3)12-9-13-19(5,6)21-7/h8,11,14-16H,9-10,12-13H2,1-7H3/b11-8+,17-14+/t16-/m1/s1 |
| InChIKey | NFGXHKASABOEEW-GYMWBFJFSA-N |
| SMILES | C(OC(C)C)(=O)/C=C(\C)/C=C/C[C@@H](C)CCCC(OC)(C)C |
| EWG's Food Scores | 1 |
| FDA UNII | 4YIQ0A94UR |
| EPA Substance Registry System | S-Methoprene (65733-16-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| Hazard Codes | Xi |
| Hazard Note | Irritant |
| HS Code | 2918999090 |
S-(+)-Methoprene price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M3580 | S-(+)-Methoprene min. 95.0 % | 65733-16-6 | 1G | $93 | 2026-04-30 | Buy |
| Cayman Chemical | 16807 | (S)-(+)-Methoprene ≥95% | 65733-16-6 | 50mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 16807 | (S)-(+)-Methoprene ≥95% | 65733-16-6 | 100mg | $68 | 2026-04-30 | Buy |
| Usbiological | 283021 | S-(+)-Methoprene ≥95% | 65733-16-6 | 1g | $389 | 2026-06-03 | Buy |
| Usbiological | 283021 | S-(+)-Methoprene ≥95% | 65733-16-6 | 5g | $641 | 2026-06-03 | Buy |
S-(+)-Methoprene Chemical Properties, Uses, Production
Description
(S)-(+)-Methoprene is a widely-used insect growth regulator. It is remarkable for its lack of significant effects against a wide variety of mammals, although concerns remain for its effects on arthropod development. Methoprene acts as an activator of the juvenile hormone receptor, known as Methoprene-tolerant or Met (Kd = 12.3 nM). Met is a transcription factor that, upon activation with juvenile hormone or methoprene, regulates gene expression that inhibits metamorphosis.
Uses
Insecticide; insect growth regulator.
Production Methods
The production of S-methoprene involves a multi-step organic synthesis starting from optically active precursors. One established method begins with (+)-dihydromyrcene, which undergoes selective hydroalumination followed by oxidation to yield S-(–)-citronellol. This intermediate is further oxidised to S-(–)-citronellal, which reacts with allylmagnesium chloride to form a key alcohol. Subsequent steps include Smidt-Moiseev oxygenation, dehydration, and Grignard reactions to build the conjugated diene ester backbone. The final transformation involves Brown solvomercuration-reduction in methanol, yielding S-methoprene with high stereochemical purity and biological activity.
Definition
ChEBI: (S)-methoprene is a methoprene. It is an enantiomer of a (R)-methoprene.
Mechanism of action
A juvenile hormone mimic (terpene). Contact and stomach action, acts by mimicing the action of the juvenile hormone keeping the insect in an immature state
Side effects
S)-methoprene alone is well tolerated by dogs and cats, with a low toxicity and high safety margin. Side effects experienced by dogs and cats after treatment with products containing (S)-methoprene can generally be attributed to the other active or inert ingredients.
References
[1] SIDDALL J B. Insect growth regulators and insect control: a critical appraisal.[J]. Environmental Health Perspectives, 1976, 14: 119-126. DOI: 10.1289/ehp.7614119
[2] WRIGHT J E. Environmental and toxicological aspects of insect growth regulators.[J]. Environmental Health Perspectives, 1976, 14: 127-132. DOI: 10.1289/ehp.7614127
[3] JEAN-PHILIPPE CHARLES. Ligand-binding properties of a juvenile hormone receptor, Methoprene-tolerant.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2011: 21128-21133. DOI: 10.1073/pnas.1116123109
[4] E. OSIR L R. Nuclear binding sites for juvenile hormone and its analogs in the epidermis of the tobacco hornworm.[J]. The Journal of Biological Chemistry, 1988, 23 1: 13812-13818. DOI: 10.1016/s0021-9258(18)68316-4
[5] ZHEN ZOU. Juvenile hormone and its receptor, methoprene-tolerant, control the dynamics of mosquito gene expression.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2013: E2173-81. DOI: 10.1073/pnas.1305293110
Pesticide Type
Insecticide; Veterinary substance
S-(+)-Methoprene Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wellman Pharmaceutical Group Limited | 15807197853 18971451745 | 15807197853@163.com | China | 3975 | 58 |
| Changzhou Book Chemical Co., Ltd. | 13606129753 13775119556 | bookchem@126.com | China | 1613 | 62 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Fuhe Chemistry Technology Co., Ltd. | 0086-21-67651709 | cfx759@hotmail.com | China | 409 | 57 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
| Hubei Jusheng Technology Co.,Ltd | 027-59599241 18871490274 | 1400878000@qq.com | China | 9506 | 58 |
| Chizhou Kailong Import and Export Trade Co., Ltd. | xg01_gj@163.com | China | 9413 | 50 | |
| Quzhou Rundong Chemical (Technology) Co. | 0570-8789886 18892685668 | info@rundongchemical.com | China | 4045 | 60 |
| Jai Radhe Sales | +(91)-(79)-26431096/65255722 | info@jairadhesales.com | India | 394 | 60 |
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- Oct 21,2024
View Latest Price from S-(+)-Methoprene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-16 | S-(+)-Methoprene
65733-16-6
|
$10.00 | 1ASSAYS | 99% | 1 ton | RongNa Biotechnology Co.,Ltd | |
 |
2026-06-02 | S-Methoprene
65733-16-6
|
$40.00 | 98.90% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-28 | S-(+)-METHOPRENE
65733-16-6
|
$9.00 | 1KG | 99.9 | 1 ton | Hebei Chuanghai Biotechnology Co,.LTD |
-
- S-(+)-Methoprene
65733-16-6
- $10.00
- 99%
- RongNa Biotechnology Co.,Ltd
-
- S-Methoprene
65733-16-6
- $40.00
- 98.90%
- TargetMol Chemicals Inc.
-
- S-(+)-METHOPRENE
65733-16-6
- $9.00
- 99.9
- Hebei Chuanghai Biotechnology Co,.LTD
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