(2S,3R,E)-2-Amino-4-icosene-1,3-diol
- CAS No.
- 6918-49-6
- Chemical Name:
- (2S,3R,E)-2-Amino-4-icosene-1,3-diol
- Synonyms
- C20-Sphingosine;Eicosaphingenine;Eicosasphingenine;Gangliosphingosine;Sphingosine (d20:1);20-Carbon-sphingosine;D-erythro-Sphingosine C-20;(2S,3R,4E)-4-Icosasphingenine;D-erythro-Sphingosine (d20:1);Sphingosine (d20:1) (Standard)
- CBNumber:
- CB82148391
- Molecular Formula:
- C20H41NO2
- Molecular Weight:
- 327.55
- MDL Number:
- MFCD08703032
- MOL File:
- 6918-49-6.mol
- MSDS File:
- SDS
| storage temp. | -20°C |
|---|---|
| solubility | DMF: 10 mg/ml; DMSO: 2 mg/ml; Ethanol: Miscible |
| form | A crystalline solid |
| color | White to off-white |
| BRN | 3547228 |
| InChI | 1S/C20H41NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(21)18-22/h16-17,19-20,22-23H,2-15,18,21H2,1H3/b17-16+/t19-,20+/m0/s1 |
| InChIKey | HTJSZHKGNMXZJN-YIVRLKKSSA-N |
| SMILES | OC[C@@](N)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCCCC |
| UNSPSC Code | 12352211 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
(2S,3R,E)-2-Amino-4-icosene-1,3-diol price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 07768 | (2S,3R,4E)-2-Amino-4-eicosene-1,3-diol ≥98.0% (TLC) | 6918-49-6 | 10mg | $203 | 2023-06-20 | Buy |
| Sigma-Aldrich | 07768 | (2S,3R,4E)-2-Amino-4-eicosene-1,3-diol ≥98.0% (TLC) | 6918-49-6 | 50mg | $867 | 2023-01-07 | Buy |
| Cayman Chemical | 10007903 | Sphingosine (d20:1) ≥98% | 6918-49-6 | 500μg | $37 | 2026-04-30 | Buy |
| Cayman Chemical | 10007903 | Sphingosine (d20:1) ≥98% | 6918-49-6 | 1mg | $69 | 2026-04-30 | Buy |
| Cayman Chemical | 10007903 | Sphingosine (d20:1) ≥98% | 6918-49-6 | 5mg | $194 | 2026-04-30 | Buy |
(2S,3R,E)-2-Amino-4-icosene-1,3-diol Chemical Properties, Uses, Production
Description
Sphingosines are long-
Uses
Sphingosine (d20:1) has been used as a reference substance in liquid chromatography/tandem mass spectrometry analysis to quantitatively analyze sphingolipids with C20- long chain bases in human central nervous tissue.
Uses
D-erythro-Sphingosine-C20 is an antagonist in cell-signaling functions however it displays an opposite modulation of cathepsin D.
Definition
ChEBI: C20 sphingosine is a sphingoid that is the C20 analogue of sphingosine. It has a role as a mouse metabolite. It is a sphingoid and an aminodiol. It is a conjugate base of a C20 sphingosine(1+).
General Description
Sphingosine (d20:1), also known as icosasphingosine, is a synthetic sphingosine with 20 carbon long chain bases (LCB). It is directly produced by the sphingolipid de novo synthesis pathway and not by hydrolysis of complex sphingolipids. In higher animals, it is one of the most abundant sphingoid bases of gangliosides.
Biochem/physiol Actions
Sphingosine (d20:1) or C20-sphingosine acts as an intermediate in the synthesis of ceramides, which are vital components of mammalian epidermis. It may be involved in regulation of epidermal differentiation. C20 long chain bases-containing sphingolipids might exhibit detrimental effect on protein homeostasis and neural functions.
References
[1] MANUELA VALSECCHI. Changes of Free Long-Chain Bases in Neuronal Cells During Differentiation and Aging in Culture[J]. Journal of Neurochemistry, 1996, 67 5: 1866-1871. DOI: 10.1046/j.1471-4159.1996.67051866.x
[2] SANDRO SONNINO Vanna C. Ganglioside molecular species containing C18- and C20-sphingosine in mammalian nervous tissues and neuronal cell cultures[J]. Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 2000, 1469 2: Pages 63-77. DOI: 10.1016/s0005-2736(00)00210-8
(2S,3R,E)-2-Amino-4-icosene-1,3-diol Preparation Products And Raw materials
Raw materials
Preparation Products
(2S,3R,E)-2-Amino-4-icosene-1,3-diol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yichang Zhongyitai Trading Co., Ltd. | 0717-6449896 13886658719 | root@zhongyitai.com | China | 1978 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Chengdu Huachun Technology Co., Ltd | 400-1166-196 15982826727 | cdhxsj@163.com | China | 14571 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
View Latest Price from (2S,3R,E)-2-Amino-4-icosene-1,3-diol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-21 | Sphingosine (d20:1)
6918-49-6
|
$223.00-688.00 | 10g | TargetMol Chemicals Inc. |
-
- Sphingosine (d20:1)
6918-49-6
- $223.00-688.00
- TargetMol Chemicals Inc.
