CANDOXATRIL
- CAS No.
- 123122-55-4
- Chemical Name:
- CANDOXATRIL
- Synonyms
- UK-79300;candoxatril;Candoxatril (UK 79300);Candoxatril [usan:inn:ban];4α-[[1-[(S)-2-(Indan-5-yloxycarbonyl)-3-(2-methoxyethoxy)propyl]cyclopentan-1-yl]carbonylamino]cyclohexane-1α-carboxylic acid;(1R,4s)-4-(1-((S)-3-((2,3-dihydro-1H-inden-5-yl)oxy)-2-((2-methoxyethoxy)methyl)-3-oxopropyl)cyclopentanecarboxamido)cyclohexanecarboxylic acid;cis-4-[[[1-[(2S)-3-[(2,3-Dihydro-1H-inden-5-yl)oxy]-2-[(2-Methoxyethoxy)Methyl]-3-oxopropyl]cyclopentyl]carbonyl]aMino]cyclohexanecarboxylic Acid;(1r,4s)-4-(1-((s)-3-((2,3-dihydro-1h-inden-5-yl)oxy)-2-((2-methoxyethoxy)methyl)-3-oxopropyl)cyclopentane-1-carboxamido)cyclohexane-1-carboxylic acid;Cyclohexanecarboxylic acid, 4-[[[1-[(2S)-3-[(2,3-dihydro-1H-inden-5-yl)oxy]-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentyl]carbonyl]amino]-,cis-
- CBNumber:
- CB82280992
- Molecular Formula:
- C29H41NO7
- Molecular Weight:
- 515.63834
- MDL Number:
- MFCD00865901
- MOL File:
- 123122-55-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 107-109° |
|---|---|
| alpha | D -5.8° (c = 1 in methanol) |
| Boiling point | 718.4±60.0 °C(Predicted) |
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 4.84±0.25(Predicted) |
| form | Solid |
| color | White to off-white |
| FDA UNII | ACP75508EE |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405 |
CANDOXATRIL price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0016160 | Candoxatril 98.19% | 123122-55-4 | 1mg | $379 | 2026-06-04 | Buy |
| ChemScene | CS-0016160 | Candoxatril 98.19% | 123122-55-4 | 5mg | $932 | 2026-06-04 | Buy |
| Biorbyt Ltd | orb1710162 | Candoxatril 98.90% | 123122-55-4 | 1mg | $340 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1710162 | Candoxatril 98.90% | 123122-55-4 | 5mg | $760 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1710162 | Candoxatril 98.90% | 123122-55-4 | 10mg | $1030 | 2026-05-06 | Buy |
CANDOXATRIL Chemical Properties, Uses, Production
Uses
Neutral endopeptidase inhibitor. Candoxatril is used in treatment of congestive heart failure.
Uses
Neutral endopeptidase inhibitor. Used in treatment of congestive heart failure.
Definition
ChEBI: The 2,3-dihydro-1H-inden-5-yl ester of the active enantiomer of candoxatrilat. Candoxatril is an orally active prodrug of candoxatrilat, a potent neutral endopeptidase (NEP, neprilysin) inhibitor used in the treatment of chronic heart fa lure.
in vivo
While the NEP inhibitors have no significant effect on body weight, food and water intake, mean blood pressure or creatinine levels, they do increase cGMP levels in the urine and affected hematopoiesis in an anti-inflammatory way. Moreover, a-SMA deposition in the kidney cortex is inversely correlated with cGMP elevation suggesting a NEP dependent antifibroti effect. High quality mRNA profiles are obtained with at least 8 independent samples per treatment group. The data confirms the cGMP dependent anti-fibrotic action of Sol-1 and further supports the potential therapeutic actions of this neutral endopeptidase inhibitor[2].
CANDOXATRIL Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Jinan Mingya Medical Technology Co., Ltd. | 0531-85828981 | 864598798@qq.com | China | 587 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7982 | 58 |
View Latest Price from CANDOXATRIL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Candoxatril
123122-55-4
|
$293.00-987.00 | 98.90% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-27 | Candoxatril
123122-55-4
|
$293.00-987.00 | 98.90% | 10g | TargetMol Chemicals Inc. |
-
- Candoxatril
123122-55-4
- $293.00-987.00
- 98.90%
- TargetMol Chemicals Inc.
-
- Candoxatril
123122-55-4
- $293.00-987.00
- 98.90%
- TargetMol Chemicals Inc.
