Bucladesine sodium | 16980-89-5

Bucladesine sodium Properties

Melting point	>173°C (dec.)
storage temp.	-20°C
solubility	H₂O: 50 mg/mL
form	powder
color	white
biological source	synthetic (organic)
Water Solubility	water: 1mg/mL
Merck	14,1463
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
InChIKey	DBXVIQJWMFGXGO-AOTDUVMNNA-N
SMILES	O([C@@H]1[C@]2([H])OP(O)(=O)OC[C@@]2([H])O[C@H]1N1C=NC2C(=NC=NC1=2)NC(=O)CCC)C(=O)CCC.[NaH] \|&1:1,2,10,13,r\|
FDA UNII	4DZN2C97A7
UNSPSC Code	41106305
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
PPE	Eyeshields, Gloves, type N95 (US)
Safety Statements	24/25
WGK Germany	2
RTECS	ES5055500
F	10-21
HS Code	29349990
Storage Class	11 - Combustible Solids

Bucladesine sodium price More Price(96)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	28745-M	Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.	16980-89-5	25mg	$150	2026-04-30	Buy
Sigma-Aldrich	28745-M	Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.	16980-89-5	100mg	$461	2026-04-30	Buy
Sigma-Aldrich	28745-M	Adenosine 3′,5′-cyclic Monophosphate, N⁶,O^2′-Dibutyryl-, Sodium Salt This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.	16980-89-5	1g	$1390	2026-04-30	Buy
Sigma-Aldrich	28745-M	Adenosine 3′,5′-cyclic Monophosphate, N⁶,O^2′-Dibutyryl-, Sodium Salt This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates P	16980-89-5	100 μg	$16040	2026-04-30	Buy
Sigma-Aldrich	28745-M	Adenosine 3′,5′-cyclic Monophosphate, N⁶,O2′-Dibutyryl-, Sodium Salt This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.	16980-89-5	28745-1GM	$1220	2023-06-20	Buy

Product number	Packaging	Price	Buy
28745-M	25mg	$150	Buy
28745-M	100mg	$461	Buy
28745-M	1g	$1390	Buy
28745-M	100 μg	$16040	Buy
28745-M	28745-1GM	$1220	Buy

Bucladesine sodium Chemical Properties,Uses,Production

Description

Bucladesine sodium is a derivative of cyclic-AMP with cardiac stimulant and peripheral vasodilatory properties. It is reported to be useful in cardiac insufficiency, especially after heart surgery.

Originator

Daiichi Seiyaku; Seishin Seiyaku (Japan)

Uses

Bucladesine sodium is an analog of cyclic AMP that stimulates cAMP-dependent protein kinase. It has vasodilator properties and is used as a cardiac stimulant.

Definition

ChEBI: Bucladesine sodium is a 3',5'-cyclic purine nucleotide.

Application

N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt has been used:
as a medium supplement for neural crest stem cells (NCSCs) differentiation
as a component of thawing medium for cryopreserved human iPSC (induced pluripotent stem cell)-derived neurons
in serum-free Dulbecco′s modified eagle′s medium (DMEM) to induce astrocyte differentiation

brand name

ACTOCIN

General Description

A cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Causes an increase in the steady state level of parathyroid hormone-related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.

Biochem/physiol Actions

Cell-permeable cAMP analog that activates cAMP dependent protein kinase (PKA).

Synthesis

Preparation of bucladesine sodium: in the flask containing cyclic adenosine monophosphate slowly added sodium hydroxide aqueous solution (3 mol/L), the process of temperature control, the drop is completed warmed to room temperature, with HCl solution (20%) to adjust the pH to 7-8, add anhydrous ethanol precipitation of white solids, filtration, drying of the sodium salt of a white solid; the sodium salt and n-butyl anhydride under the protection of N2 warmed to 140 reaction, TLC monitoring the reaction is complete, and then reduced to room temperature. TLC monitoring, the reaction is complete after the drop to room temperature, slowly add methyl tert-butyl ether, the process of vigorous stirring, get nearly white solid crude product. A mixed solution of methyl tert-butyl ether and acetone was resuspended to obtain a white powdery target product.

storage

Store at -20°C

Background

Dibutyryl-cAMP, also known as bucladesine, is an analog of the second messenger cyclic adenosine 3'5'-monophosphate. Dibutyryl-cAMP is a phosphodiesterase inhibitor and a cAMP-dependent protein kinase activator that mimics the action of cAMP in cells. The anti-inflammatory activity of Dibutyryl-cAMP makes it an option for the treatment of skin inflammation. Exposure of rat glial cells to Dibutyryl-cAMP inhibited cell growth and increased glial fibrillary acidic protein levels, resulting in a change toward an astrocytic phenotype. Treatment of rat hepatocytes with Dibutyryl-cAMP suppressed both iNOS mRNA and protein expression, decreased iNOS promoter activity, and reduced DNA binding of the transcription factor NF-κB. Dibutyryl-cAMP treatment increased phosphorylated cAMP-response element-binding protein via protein kinase A signaling in rat pulmonary fibroblasts. Cells treated with Dibutyryl-cAMP exhibited a reduced number and size of silicosis nodules, and inhibited myofibroblast differentiation and extracellular matrix deposition.

References

1) Bartschet al.(2003),Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem.,3841321
2) Carranzaet al.(1998),Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol.,15511
3) Heiet al.(1991),Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol.,39233
4) Imamuraet al.(1998),Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA,956139
5) Xiaet al.(2016),Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep.,620270

Bucladesine sodium Preparation Products And Raw materials

Raw materials

Preparation Products

Bucladesine sodium Suppliers

Global( 406)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou Runyan Medical Technology Co., LTD	571-13989459766 18112526015	sales@runyanpharma.com	China	496	58
TargetMol Chemicals Inc.	021-021-33632979 15002134094	marketing@targetmol.com	China	7993	58
Hangzhou Meiya Pharmaceutical Co.,ltd.	021-33686691 18001850931	wangjm@meiyapharm.com	China	51	58
Shanghai Peiling Biological Technology Co., LTD	13127581762 13127581762	peilingchem@sina.com	China	469	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6746	52

Supplier	Advantage
Hangzhou Runyan Medical Technology Co., LTD	58
TargetMol Chemicals Inc.	58
Hangzhou Meiya Pharmaceutical Co.,ltd.	58
Shanghai Peiling Biological Technology Co., LTD	58
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
TCI (Shanghai) Development Co., Ltd.	81
Adamas Reagent, Ltd.	59
Nanjing Chemlin Chemical Co., Ltd	64
XiaoGan ShenYuan ChemPharm co,ltd	52

View Lastest Price from Bucladesine sodium manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-15	Bucladesine sodium 16980-89-5	$31.00-79.00		99.65%	10g	TargetMol Chemicals Inc.
2026-07-15	Bucladesine sodium 16980-89-5	$31.00-79.00		99.65%	10g	TargetMol Chemicals Inc.
2026-06-02	Bucladesine sodium salt (DB-cAMP.Na) 16980-89-5		1kg	≥95%	5000kg	Hangzhou Meiya Pharmaceutical Co Ltd

Bucladesine sodium
16980-89-5
$31.00-79.00
99.65%
TargetMol Chemicals Inc.

Bucladesine sodium
16980-89-5
$31.00-79.00
99.65%
TargetMol Chemicals Inc.

Bucladesine sodium salt (DB-cAMP.Na)
16980-89-5
≥95%
Hangzhou Meiya Pharmaceutical Co Ltd

Bucladesine sodium Spectrum

Bucladesine sodium(16980-89-5)¹HNMR Bucladesine sodium(16980-89-5)IR1 Bucladesine sodium(16980-89-5)IR2

16980-89-5(Bucladesine sodium)Related Search:

Adenosine 3',5'-cyclic monophosphate sodium salt β-Nicotinamide adenine dinucleotide 8-CHLORO-CAMP 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT MALANTIDE

N-(2-(METHYLAMINO)ETHYL)ISOQUINOLINE- HA-1004 DIHYDROCHLORIDE ARG-ARG-LYS-ALA-SER-GLY-PRO 8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Bucladesine (calciuM salt)

6-MB-CAMP SODIUM SALT 2'-O-MB-CAMP SODIUM SALT SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED

Butyramide Cyclic AMP Bucladesine

1of4

dibutylcyclicampsodium dibutylcyclicampsodiumsalt dt5621sodiumsalt e,butyrate(ester),monosodiumsalt monosodiumdibutyrylcyclicamp n-(9-beta-d-ribofuranosyl-9h-purin-6-yl)-butyramidcyclichydrogenphosphat n6,02’-dibutyryladenosine3’,5’-cyclicmonophosphatesodiumsalt n6,2’-o-dibutyryladenosine-3’,5’-cyclicmonophosphate(dbcamp),sodiumsalt N,2'-O-Dibutanoyladenosine 3',5'-(phosphoric acid sodium) salt N,2'-O-Dibutyryladenosine-3',5'-phosphoric acid sodium salt Sodium bucladesine ,5Õ -cyclophosphate sodium salt monohydrate N6-2Õ -O-Dibutyryl-adenosine 3Õ Adenosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, monosodium salt N6,2'-O-DIBUTYRYLADENOSINE 3':5'-CYCLIC MONOPHOSPHA N6,2'-O-DIBUTYRYLADENOSINE-3',5'-CYCLO-P HOSPHATE SO-SALT Dibutyacyladenosine 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, adenosine deriv. Butyramide, N-(9-b-D-ribofuranosyl-9H-purin-6-yl)-, cyclic hydrogen phosphate butyrate (ester), monosodium salt (8CI) DC 2797 Dibutyryl 3',5'-cyclic AMP sodium salt Dibutyryl cyclic AMP monosodium salt Dibutyryl cyclic AMP sodium N6,2'-O-Dibutyryl-3',5'-cyclic AMP sodium salt N6,2'-O-Dibutyryladenosine-3',5'-monophosphate monosodium salt N6,O2'-Dibutyryl-3',5'-cyclic AMP sodium salt N-6,O-2'-Dibutyryladenosine cyclic 3',5'-monophosphate sodium salt Sodium N6,2'-O-dibutyryladenosine 3',5'-cyclic phosphate DIBUTYRYL-CYCLICAMP BUCLADESINE[N-6,O-2''-DIBUTYRYL ADENOSINE CYCLIC 3'',5''-MONOPHOSPHATE] N6,2'-O-DIBUTRYL-ADENISINE-3',5'-CYCLICMONPHOSPHATE SODIUM SALT Bucladesine sodium salt, Dibutyryl cAMP sodium salt, Dibutyryl cyclic-AMP sodium salt Bucladesine, Dibutyryl cyclic-AMP N6,2μ-O-Dibutyryladenosine 3μ,5μ-cyclic monophosphate monohydrate sodium salt ibutyryl cyclic AMP sodium N6,O2-DIBUTYRYLADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE NA Dibutyacyladenosine cyclphosphate Adenosine,N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, sodiuM salt(1:1) Adenosine 3?,5?-cyclic Monophosphate, N?,O Dibutyryl-cAMP sodium salt, >=98% adenosine,n-(1-oxobutyl)-,cyclic3’,5’-(hydrogenphosphate)-2’-butanoate,m bucladesinesodium butyramide,n-(9-beta-d-ribofuranosyl-9h-purin-6-yl)-,cyclichydrogenphosphate,butyrate(ester),monosodiumsalt dibutylcampsodiumsalt sodiumdibutyryl3’,5’-cyclicamp sodiumdibutyrylcamp N6, O2-DIBUTYRYLADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE SODIUM SALT N6,O2'-DIBUTYRYL ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT N6,O2'-DIBUTYRYLADENOSINE-3':5'-PHOSPHATE CYCLIC NA-SALT N6,O2'-DIBUTYRYLADENOSINE-3',5'-PHOSPHATE CYCLIC SODIUM SALT N6,2'-O-DIBUTYRYLADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT N6,2'-O-DIBUTYRYLADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT N6,2'-O-DIBUTYRYLADENOSINE-3':5'-CYCLIC MONOPHOSPHORIC ACID, SODIUM ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE, N6,O2'-DIBUTYRYL-, SODIUM SALT ADENOSINE-3',5'-CYCLIC MONOPHOSPHORIC ACID, N,2'O-DIBUTYRYL, SODIUM SALT BUCLADESINE NA