ChemicalBook >> CAS DataBase List >>PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED

PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED

PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED structure

CAS No.: 201422-03-9

Chemical Name:: PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED

Synonyms: MYR-GRTGRRNAI-NH2;PKI 14-22 amide, myr;PKI 14-22 AMIDE, MYRISTOYLATED;PKI 14-22 AMIDE, CELL-PERMEABLE;MYRISTOYLATED PKI (14-22) AMIDE;PKI 14-22 amide,myristoylated ，P1154;PROTEIN KINASE A INHIBITOR 14-22 AMIDE, MYRISTOYLATED;MYRISTOYLATED PROTEIN KINASE A INHIBITOR AMIDE 14-22, CELL-PERMEABLE;PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED;L-Isoleucinamide, N-(1-oxotetradecyl)glycyl-L-arginyl-L-threonylglycyl-L-arginyl-L-arginyl-L-asparaginyl-L-alanyl-

CBNumber:: CB0101910

Molecular Formula:: C53H100N20O12

Molecular Weight:: 1209.49

MDL Number:: MFCD01076529

MOL File:: 201422-03-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:09

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PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED Properties

storage temp.	-20°C
solubility	Soluble to 1 mg/ml in DMSO
form	Solid.
color	White to off-white

PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	256277	PKI 14-22 amide, myristoylated Asreported	201422-03-9	1mg	$389	2026-06-03	Buy
ChemScene	CS-0029295	PKI 14-22 amide,myristoylated 98.87%	201422-03-9	1mg	$162	2026-06-04	Buy
ChemScene	CS-0029295	PKI 14-22 amide,myristoylated 98.87%	201422-03-9	5mg	$487	2026-06-04	Buy
ApexBio Technology	B9009	PKI 14-22 amide, myristoylated	201422-03-9	1mg	$203	2026-05-06	Buy
aablocks	AA01ENMU	PKI 14-22 amide，myristoylated ≥98%	201422-03-9	5mg	$271	2026-05-30	Buy

Product number	Packaging	Price	Buy
256277	1mg	$389	Buy
CS-0029295	1mg	$162	Buy
CS-0029295	5mg	$487	Buy
B9009	1mg	$203	Buy
AA01ENMU	5mg	$271	Buy

PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED Chemical Properties,Uses,Production

Uses

PKI 14-22 amide,myristoylated is a potent cAMP-dependent PKA inhibitor. PKI 14-22 amide,myristoylated reduces the IgG-mediated phagocytic response and also inhibits neutrophil adhesion[1].

Biological Activity

myristoylated pki (14-22) amide is an effective inhibitor of camp-dependent protein kinase (pka) and blocks hyperalgesia produced by spinal administration of 8-bromo-camp. [1]pkas are the major mediators of camp signaling in eukaryotes. pkas play an important role in several biological processes such as gene expression, apoptosis, tissue differentiation and cellular proliferation. pkas play these functions through the phosphorylation of protein substrates at serine/threonine residues. [2]pkas play a key role in neutrophil phagocytosis. camp/pkas regulate f-actin reorganization during receptor-mediated phagocytosis, particularly triggered by igg-fcr interaction. myristoylated pki 14-22 amide reduced the igg-mediated phagocytic response in a manner of dose-dependent. when the concentration is higher than 10 μm, pki 14-22 amide can inhibit neutrophil adhesion, which make the phagocytosis measurements impossible to perform. [1]because the unregulated activity of pka in mammalian cells has been implicated in the pathogenesis of several types of cancer, the development of pki (14–22) amide has been pursued as a potential treatment for these types of cancer and many other diseases related with pkas.[1,2]

storage

Store at -20°C

References

[1] ydrenius l1, majeed m, etal. , activation of camp-dependent protein kinase is necessary for actin rearrangements in human neutrophils during phagocytosis. j leukoc biol. 2000 apr;67(4):520-8.
[2] swierczewski be, davies sj. developmental regulation of protein kinase a expression and activity in schistosoma mansoni. int j parasitol. 2010 jul;40(8):929-35.

PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED Preparation Products And Raw materials

Raw materials

Preparation Products

PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED Suppliers

Global( 59)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Creative Peptides		info@creative-peptides.com	United States	6083	56
Nanjing Leon Biological Technology Co., Ltd.	025-84523390 -127; 17705183659	sales@njleonbiotech.com	China	5501	55
Hangzhou Peptidego Biotech Co.,Ltd.	0571-87213919 15967184799	Eric@peptidego.com	China	7872	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20000	58
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10378	58
Wuxi Helen Biotechnology Co., Ltd.,	0510-85629785 18013409632	sales@reading-chemicals.com	China	14072	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8137	58

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Bide Pharmatech Ltd.	60
Creative Peptides	56
Nanjing Leon Biological Technology Co., Ltd.	55
Hangzhou Peptidego Biotech Co.,Ltd.	58
Alfa Chemistry	58
BOC Sciences	58
Zhejiang J&C Biological Technology Co.,Limited	58
Wuxi Helen Biotechnology Co., Ltd.,	58
MedBioPharmaceutical Technology Inc	58

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PKI 14-22 AMIDE, CELL-PERMEABLE PKI 14-22 AMIDE, MYRISTOYLATED PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED PROTEIN KINASE A INHIBITOR 14-22 AMIDE, MYRISTOYLATED MYRISTOYLATED PKI (14-22) AMIDE MYRISTOYLATED PROTEIN KINASE A INHIBITOR AMIDE 14-22, CELL-PERMEABLE MYR-GRTGRRNAI-NH2 L-Isoleucinamide, N-(1-oxotetradecyl)glycyl-L-arginyl-L-threonylglycyl-L-arginyl-L-arginyl-L-asparaginyl-L-alanyl- PKI 14-22 amide, myr (S)-N1-((S)-1-(((2S,3S)-1-Amino-3-methyl-1-oxopentan-2-yl)amino)-1-oxopropan-2-yl)-2-((2S,5S,11S,14S)-2,5,14-tris(3-guanidinopropyl)-11-((R)-1-hydroxyethyl)-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazadotriacontanamido)succinamide PKI 14-22 amide,myristoylated ，P1154 201422-03-9 C53H100N20O12