1-CBZ-2-PIPERIDINECARBOXYLIC ACID
- CAS No.
- 28697-07-6
- Chemical Name:
- 1-CBZ-2-PIPERIDINECARBOXYLIC ACID
- Synonyms
- Z-PIP-OH;Z-DL-Pip-OH;Z-PIPECOLIC ACID;Z-PIPECOLINIC ACID;1-Cbz-pipecolic Acid;1-Carbobenzoxypipecolic Acid;1-CBZ-2-PIPERIDINECARBOXYLIC ACID;1-Benzyloxycarbonylpipecolic Acid;1-CBZ-PIPERIDINE-2-CARBOXYLIC ACID;1-N-Cbz-piperidine-2-carboxylic acid
- CBNumber:
- CB8239288
- Molecular Formula:
- C14H17NO4
- Molecular Weight:
- 263.29
- MDL Number:
- MFCD01863568
- MOL File:
- 28697-07-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Risk Statements | 20/21/22 | |||||||||
| Safety Statements | 24/25-36/37/38-29/56-41-45-3/7/9 | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
1-CBZ-2-PIPERIDINECARBOXYLIC ACID price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C3382 | 1-Carbobenzoxy-2-piperidinecarboxylic Acid >98.0%(GC)(T) | 28697-07-6 | 1g | $49 | 2026-04-30 | Buy |
| TCI Chemical | C3382 | 1-Carbobenzoxy-2-piperidinecarboxylic Acid >98.0%(GC)(T) | 28697-07-6 | 5g | $145 | 2026-04-30 | Buy |
| AstaTech | 20064 | 1-N-CBZ-PIPERIDINE-2-CARBOXYLIC ACID 97% | 28697-07-6 | 5G | $10 | 2026-04-30 | Buy |
| AstaTech | 20064 | 1-N-CBZ-PIPERIDINE-2-CARBOXYLIC ACID 97% | 28697-07-6 | 25G | $23 | 2026-04-30 | Buy |
| Apolloscientific | OR1757 | N-Carbobenzyloxypiperidine-2-carboxylic acid 98% | 28697-07-6 | 5g | $21 | 2026-06-04 | Buy |
1-CBZ-2-PIPERIDINECARBOXYLIC ACID Chemical Properties,Uses,Production
Chemical Properties
White solid
Uses
1,2-Piperidinedicarboxylic Acid 1-(Phenylmethyl) Ester is used to prepare disubstituted azetidinones as selective inhibitors of cysteine protease cathepsin K. It is also used to synthesize 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) as the Poly(ADP-ribose) Polymerase (PARP) inhibitor for the treatment of cancer.
Synthesis
501-53-1
4043-87-2
28697-07-6
10 g of 2-piperidinecarboxylic acid was added to a 250 mL four-neck flask, dissolved in 80 g of 10% aqueous sodium hydroxide solution and stirred until completely dissolved. Subsequently, a mixture of 15.7 g of benzyl chloroformate and 25 g of 10% aqueous sodium hydroxide solution was added dropwise. The reaction was stirred continuously at room temperature for 12 hours. Upon completion of the reaction, the reaction mixture was diluted with 100 mL of ether, followed by adjusting the pH of the aqueous layer with dilute hydrochloric acid to weakly acidic. The aqueous layer was extracted three times with ether and all organic layers were combined. The organic layer was dried with anhydrous magnesium sulfate, filtered, and the organic solvent was concentrated under reduced pressure to give 19.6 g of 1-N-benzyloxycarbonyl-2-piperidinecarboxylic acid in 96.1% yield.
References
[1] Patent: US6337423, 2002, B1. Location in patent: Example 10
[2] Patent: CN105418489, 2016, A. Location in patent: Paragraph 0010; 0015
[3] Journal of Organic Chemistry, 1993, vol. 58, # 4, p. 860 - 866
[4] Journal of Chemical Research, 2008, # 8, p. 468 - 472
[5] Patent: WO2010/21797, 2010, A1. Location in patent: Page/Page column 106
1-CBZ-2-PIPERIDINECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Chem-Milestone Co., Ltd | 021-50273253 13641951838 | chemmilestone@163.com | China | 149 | 62 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
View Lastest Price from 1-CBZ-2-PIPERIDINECARBOXYLIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 1-CBZ-2-PIPERIDINECARBOXYLIC ACID
28697-07-6
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 1-CBZ-2-PIPERIDINECARBOXYLIC ACID
28697-07-6
- $1.00
- 99%
- Career Henan Chemical Co
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