7-Bromo-2,3-dihydro-1-benzofuran
- CAS No.
- 206347-30-0
- Chemical Name:
- 7-Bromo-2,3-dihydro-1-benzofuran
- Synonyms
- 7-Bromo-2,3-dihydrobenzofuran;7-Bromo-2,3-dihydrobenzofurane;7-Bromo-2,3-dihydro-1-benzofuran;Benzofuran, 7-bromo-2,3-dihydro-;7-Bromo-2,3-dihydrobenzo[b]furan
- CBNumber:
- CB82449683
- Molecular Formula:
- C8H7BrO
- Molecular Weight:
- 199.04
- MDL Number:
- MFCD09266210
- MOL File:
- 206347-30-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H302-H319-H335 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362 |
| HS Code | 2932990090 |
7-Bromo-2,3-dihydro-1-benzofuran price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR346457 | 7-Bromo-2,3-dihydrobenzofuran >97% | 206347-30-0 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR346457 | 7-Bromo-2,3-dihydrobenzofuran >97% | 206347-30-0 | 1g | $25 | 2026-06-04 | Buy |
| Apolloscientific | OR346457 | 7-Bromo-2,3-dihydrobenzofuran >97% | 206347-30-0 | 5g | $100 | 2026-06-04 | Buy |
| Apolloscientific | OR346457 | 7-Bromo-2,3-dihydrobenzofuran >97% | 206347-30-0 | 25g | $430 | 2026-06-04 | Buy |
| Matrix Scientific | 129958 | 7-Bromo-2,3-dihydro-benzofuran | 206347-30-0 | 1.00g | $145 | 2026-05-18 | Buy |
7-Bromo-2,3-dihydro-1-benzofuran Chemical Properties, Uses, Production
Synthesis
206347-32-2
206347-30-0
Synthesis of 7-bromo-2,3-dihydrobenzofuran: In a dry reaction flask, 1,3-dibromo-2-(2-bromoethoxy)benzene (11.5 g, 32.0 mmol) was dissolved in a mixed solvent of 115 mL of anhydrous THF and 28 mL of hexane. The reaction system was cooled to -78 °C under nitrogen protection, and 2.5 M n-butyllithium (n-BuLi, 13.0 mL, 32.5 mmol) solution was slowly added dropwise for a controlled time of 30 min. After the dropwise addition was completed, the reaction was kept at -78 °C for 30 min and then the reaction system was slowly warmed up to 0 °C. After completion of the reaction, the mixture was carefully poured into 100 mL of ice water and the aqueous phase was extracted with ether (3 x 50 mL). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give a light yellow oily crude product. The crude product was purified by silica gel column chromatography with gradient elution of ethyl acetate/hexane to afford colorless needle-like crystals of 7-bromo-2,3-dihydrobenzofuran (5.00 g, 78% yield). The structure of the product was confirmed by 1H NMR (500 MHz, DMSO-d6): δ 7.27 (dd, J=1,8Hz, 1H), 7.20 (dd, J=1,7.5Hz, 1H), 6.75 (t, J=7.8Hz, 1H), 4.59 (t, J=9Hz, 2H), 3.28 (t, J=8.8Hz, 2H).
References
[1] Tetrahedron Letters, 1998, vol. 39, # 15, p. 2219 - 2222
[2] Patent: US2006/30583, 2006, A1. Location in patent: Page/Page column 104
[3] Patent: EP1972628, 2008, A1. Location in patent: Page/Page column 56-57
[4] Patent: US2010/16297, 2010, A1. Location in patent: Page/Page column 34
7-Bromo-2,3-dihydro-1-benzofuran Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wulechem Co., Ltd. | 13761914825 | wulesian@wulechem.com | China | 285 | 58 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai Keepontech Co.,Ltd | 021-54849683 13601642561 | sales@keepontech.com | China | 998 | 59 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Tianjin Anhao Biological Technology Co., Ltd. | sales@ahpharmatech.com | China | 5734 | 55 |
