ChemicalBook >> CAS DataBase List >>2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile structure

CAS No.: 1073354-05-8

Chemical Name:: 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile

Synonyms: 3-Cyano-2-methoxypyridine-5-boronic acid,pinacol;5-Cyano-6-methoxypyridine-3-boronic acid pinacol ester;3-CYANO-2-METHOXYPYRIDINE-5-BORONIC ACID, PINACOL ESTER;2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile;2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile;3-Pyridinecarbonitrile, 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

CBNumber:: CB82458285

Molecular Formula:: C13H17BN2O3

Molecular Weight:: 260.1

MDL Number:: MFCD11504968

MOL File:: 1073354-05-8.mol

Last updated:2026-09-12 18:55:35

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2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile Properties

storage temp.	under inert gas (nitrogen or Argon) at 2-8°C

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H312-H332
Precautionary statements	P280
HS Code	2933399990

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
aablocks	AA0084T0	2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile 95%	1073354-05-8	100mg	$31	2026-05-28	Buy
aablocks	AA0084T0	2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile 95%	1073354-05-8	250mg	$40	2026-05-28	Buy
aablocks	AA0084T0	2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile 95%	1073354-05-8	1g	$95	2026-05-28	Buy
aablocks	AA0084T0	2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile 95%	1073354-05-8	5g	$474	2026-05-28	Buy
aablocks	AA0084T0	2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile 95%	1073354-05-8	10g	$807	2026-05-28	Buy

Product number	Packaging	Price	Buy
AA0084T0	100mg	$31	Buy
AA0084T0	250mg	$40	Buy
AA0084T0	1g	$95	Buy
AA0084T0	5g	$474	Buy
AA0084T0	10g	$807	Buy

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile Chemical Properties, Uses, Production

Synthesis

941294-54-8

73183-34-3

2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)NICOTINONITRILE

1073354-05-8

General Steps: Preparation of solution A: PdCl2(dppf)-CH2Cl2 (0.958 g, 1.174 mmol), KOAc (6.91 g, 70.4 mmol) and bis(pinacolato)diboron (7.15 g, 28.2 mmol) were added sequentially to a 250 mL flask followed by degassing. Preparation of solution B: In another vial, 5-bromo-2-methoxynicotinonitrile (5 g, 23.47 mmol) was dissolved in 100 mL of anhydrous dioxane. Solution B was slowly added to solution A. The mixed reaction solution was heated to 80 °C and maintained for 16 hours. After completion of the reaction, the mixture was cooled to room temperature, diluted with EtOAc and filtered to remove insoluble solids. The filtrate was concentrated under reduced pressure to give a black oily substance. Purification by rapid chromatography on silica gel (eluent: CH2Cl2/MeOH, 95/5) afforded the target product 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile (5.7 g, 89% yield) as a beige powder. Product Characterization: 1H-NMR (400 MHz, DMSO-d6, 298 K): δ 1.31 (s, 12H), 4.03 (s, 3H), 8.31 (s, 1H), 8.62 (s, 1H). MS: m/z 261.5 [M + 1]+, retention time (Method 2) = 1.47 min.

References

[1] Patent: WO2013/57711, 2013, A1. Location in patent: Page/Page column 50
[2] Patent: WO2013/88404, 2013, A1. Location in patent: Page/Page column 97
[3] Patent: US2015/342951, 2015, A1. Location in patent: Paragraph 0863-0867
[4] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 19, p. 6477 - 6485

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile Preparation Products And Raw materials

Raw materials

5-Bromo-3-cyano-2-methoxypyridine Bis(pinacolato)diboron Potassium Acetate 1,4-Dioxane

Preparation Products

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile Suppliers

Global Suppliers ( 50)

Supplier	Tel	Email	Country	ProdList	Advantage
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Tetranov Biopharm	13526569071	sales@leadmedpharm.com	China	7881	64
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59
Nanjing Norris-Pharm Technology Co., Ltd	13901585132	sales@norris-pharm.com	China	8869	55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 13913916777	cfzhang@aikonchem.com	China	19902	55
9ding chemical ( Shanghai) Limited	4009209199	sales@9dingchem.com	China	18201	56
SynAsst Chemical.	021-60343070		China	12731	55
Cantotech Chemicals, Ltd.	86-0755-86635001	cantotech@126.com	China	4554	55
Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd.	19943855286	94644163@qq.com	China	1934	56

Supplier	Advantage
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Tetranov Biopharm	64
Shanghai Longsheng chemical Co.,Ltd.	59
Nanjing Norris-Pharm Technology Co., Ltd	55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	55
9ding chemical ( Shanghai) Limited	56
SynAsst Chemical.	55
Cantotech Chemicals, Ltd.	55
Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd.	56

1073354-05-8 (2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile) Related Search:

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3-CYANO-2-METHOXYPYRIDINE-5-BORONIC ACID, PINACOL ESTER 3-Cyano-2-methoxypyridine-5-boronic acid,pinacol 5-Cyano-6-methoxypyridine-3-boronic acid pinacol ester 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile 3-Pyridinecarbonitrile, 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile 1073354-05-8