Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate
![Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate Structure](CAS2/GIF/1080026-94-3.gif)
- CAS No.
- 1080026-94-3
- Chemical Name:
- Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate
- Synonyms
- ethyl 4H,5H,6H,7H-thieno[3,2-c]pyridine-2-carboxylate;Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate;4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid ethyl ester;Thieno[3,2-c]pyridine-2-carboxylic acid, 4,5,6,7-tetrahydro-, ethyl ester
- CBNumber:
- CB82470199
- Molecular Formula:
- C10H13NO2S
- Molecular Weight:
- 211.28
- MDL Number:
- MFCD10566074
- MOL File:
- 1080026-94-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 072458 | Ethyl 4,5,6,7-tetrahydrothieno-[3,2-c]pyridine-2-carboxylate | 1080026-94-3 | 100.00mg | $62 | 2026-05-18 | Buy |
| Matrix Scientific | 072458 | Ethyl 4,5,6,7-tetrahydrothieno-[3,2-c]pyridine-2-carboxylate | 1080026-94-3 | 250.00mg | $127 | 2026-05-18 | Buy |
| Matrix Scientific | 072458 | Ethyl 4,5,6,7-tetrahydrothieno-[3,2-c]pyridine-2-carboxylate | 1080026-94-3 | 1.00g | $311 | 2026-05-18 | Buy |
| aablocks | AA007DLX | Ethyl 4，5，6，7-tetrahydrothieno[3，2-c]pyridine-2-carboxylate 95% | 1080026-94-3 | 100mg | $44 | 2026-05-28 | Buy |
| aablocks | AA007DLX | Ethyl 4，5，6，7-tetrahydrothieno[3，2-c]pyridine-2-carboxylate 95% | 1080026-94-3 | 250mg | $91 | 2026-05-28 | Buy |
Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate Chemical Properties, Uses, Production
Synthesis
![5-TERT-BUTYL 2-ETHYL 6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-2,5(4H)-DICARBOXYLATE](/CAS/GIF/623564-30-7.gif)
623564-30-7
![Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate](/CAS2/GIF/1080026-94-3.gif)
1080026-94-3
General procedure for the synthesis of ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate from ethyl 5-Boc-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate: to a 100 mL round-bottom flask containing ethyl 5-Boc-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate (1 g. 3.21 mmol) in a 100 mL round-bottomed flask was added to dichloromethane (16 mL) followed by slow addition of trifluoroacetic acid (1.48 mL, 19.3 mmol). The reaction mixture was stirred at room temperature for 60 minutes. After the reaction was completed, saturated aqueous sodium bicarbonate (10 mL) and dichloromethane (10 mL) were added to the mixture. After separating the organic layer, the aqueous phase was extracted twice with dichloromethane (20 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the oily product ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate (0.547 g, 81% yield).LCMS(FA)ES+: m/z 212.
References
[1] Patent: WO2010/151317, 2010, A1. Location in patent: Page/Page column 108
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 18, p. 7201 - 7211
[3] MedChemComm, 2016, vol. 7, # 5, p. 960 - 965
[4] Patent: WO2012/117421, 2012, A1. Location in patent: Page/Page column 40
[5] Patent: US2010/99664, 2010, A1. Location in patent: Page/Page column 32
Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate Preparation Products And Raw materials
Ethyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate Suppliers
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