MKC-1
- CAS No.
- 125313-92-0
- Chemical Name:
- MKC-1
- Synonyms
- MKC-1;Ro 31-7453;MKC-1, 10 mM in DMSO;3-(1-Methylindol-3-yl)-4-(1-Methyl-6-nitroindol-3-yl)pyrrole-2,5-dione;3-(1-Methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(1-methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-;3-(1-Methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-1H-pyrrole-2,5-dione , MKC-1;inhibit,mTOR,Apoptosis,Protein kinase B,PKB,MKC 1,renal cell cancer,Caki-1,Mammalian target of Rapamycin,orally active,Microtubule/Tubulin,MKC-1,Akt,pancreatic cancer,Inhibitor,MKC1
- CBNumber:
- CB82583147
- Molecular Formula:
- C22H16N4O4
- Molecular Weight:
- 400.39
- MDL Number:
- MFCD11983162
- MOL File:
- 125313-92-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 173-174 °C |
|---|---|
| Boiling point | 714.5±60.0 °C(Predicted) |
| Density | 1.49±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| form | Solid |
| pka | 7.71±0.60(Predicted) |
| color | Orange to red |
| NCI Dictionary of Cancer Terms | Ro 31-7453 |
| FDA UNII | DNZ11VPY7Q |
| NCI Drug Dictionary | MKC-1 |
MKC-1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0007705 | MKC-1 99.78% | 125313-92-0 | 5mg | $162 | 2026-06-04 | Buy |
| ChemScene | CS-0007705 | MKC-1 99.78% | 125313-92-0 | 10mg | $260 | 2026-06-04 | Buy |
| ChemScene | CS-0007705 | MKC-1 99.78% | 125313-92-0 | 25mg | $433 | 2026-06-04 | Buy |
| ChemScene | CS-0007705 | MKC-1 99.78% | 125313-92-0 | 50mg | $650 | 2026-06-04 | Buy |
| ChemScene | CS-0007705 | MKC-1 99.78% | 125313-92-0 | 100mg | $910 | 2026-06-04 | Buy |
MKC-1 Chemical Properties, Uses, Production
Uses
MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family[1][2][3].
in vivo
MKC-1 (200 mg/kg, orally, daily) significantly increased the median survival time (MST) of mice bearing Caki-1 renal cell xenograft tumors[3].
References
[1] Wang M, et al. The first design and synthesis of [11C]MKC-1 ([11C]Ro 31-7453), a new potential PET cancer imaging agent. Nucl Med Biol. 2010 Oct;37(7):763-75. DOI:10.1016/j.nucmedbio.2010.04.186
[2] Faris JE, et al. A phase 2 study of oral MKC-1, an inhibitor of importin-β, tubulin, and the mTOR pathway in patients with unresectable or metastatic pancreatic cancer. Invest New Drugs. 2012 Aug;30(4):1614-20. DOI:10.1007/s10637-011-9708-3
[3] Burke P, et al. MKC-1 significantly increases survival of mice bearing renal cell carcinoma Caki-1 xenograft tumors through inhibition of the Akt/mTOR pathway[J]. Molecular Cancer Therapeutics, 2007(12):3524S-3525S.
MKC-1 Preparation Products And Raw materials
Raw materials
Preparation Products
MKC-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9711 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5731 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Kaiwei Chemical Technology Co., Ltd. | 021-58461859 15821823057 | service@aiviche.com | China | 49299 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
