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ChemicalBook >> CAS DataBase List >>5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride

5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride

5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride Structure
5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride structure
CAS No.
209481-24-3
Chemical Name:
5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride
Synonyms
SB 271046A;SB 271046A; SB-271046A;SB-271046A >=98% (HPLC);SB 271046 HCl (SB-271046A);SB 271046 hydrochloride, 10 mM in DMSO;SB 271046 hydrochloride, 5-HT6 antagonist;4-[(3-chloro-1,4-dioxonaphthalen-2-yl)amino]benzenesulfonamide;5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzo-thiophenesulfonamide hydrochloride;5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride;Benzo[b]thiophene-2-sulfonaMide, 5-chloro-N-[4-Methoxy-3-(1-piperazinyl)phenyl]-3-Methyl-, Monohydrochloride
CBNumber:
CB82604235
Molecular Formula:
C20H23Cl2N3O3S2
Molecular Weight:
488.44
MDL Number:
MFCD10565914
MOL File:
209481-24-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
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5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride Properties

storage temp. 2-8°C
solubility DMSO: >20mg/mL
form powder
color White to light brown
InChI 1S/C20H22ClN3O3S2.ClH/c1-13-16-11-14(21)3-6-19(16)28-20(13)29(25,26)23-15-4-5-18(27-2)17(12-15)24-9-7-22-8-10-24;/h3-6,11-12,22-23H,7-10H2,1-2H3;1H
InChIKey RMXZRJYGJMSDQK-UHFFFAOYSA-N
SMILES Cl.COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N4CCNCC4
FDA UNII X289JNP23G
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  nwg
Storage Class 11 - Combustible Solids

5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S5326 SB-271046A ≥98% (HPLC) 209481-24-3 5mg $101 2026-04-30 Buy
Sigma-Aldrich S5326 SB-271046A ≥98% (HPLC) 209481-24-3 25mg $397 2026-04-30 Buy
Cayman Chemical 18513 SB-271046 (hydrochloride) ≥95% 209481-24-3 5mg $90 2026-04-30 Buy
Cayman Chemical 18513 SB-271046 (hydrochloride) ≥95% 209481-24-3 10mg $168 2026-04-30 Buy
Cayman Chemical 18513 SB-271046 (hydrochloride) ≥95% 209481-24-3 25mg $392 2026-04-30 Buy
Product number Packaging Price Buy
S5326 5mg $101 Buy
S5326 25mg $397 Buy
18513 5mg $90 Buy
18513 10mg $168 Buy
18513 25mg $392 Buy

5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride Chemical Properties, Uses, Production

Uses

5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methyl-benzo[b]thiophene-2-sulfonamide Hydrochloride is a 5-Hydroxytryptamine6 receptor antagonist.

Biological Activity

The first potent and selective 5-HT6 antagonist. Training in cognitive tasks, as well as administration SB-271046, induces an increase in pERK1/2 and pCREB1 levels, while CREB2 levels are significantly reduced; cognition-enhancing properties of SB-271046 are attributed to the effect on pERK1/2, not pCREB1/2. SB-271046 reverses MK-801-induced, but not scopolamine-induced, learning impairments. However, with coadministration of galanthamine, both types of learning impairments were ameliorated.

in vivo

SB 271046 Hydrochloride (10mg/kg; p.o.) produces an increase in seizure threshold over a wide-dose range in the rat maximal electroshock seizure threshold (MEST) test, with a minimum effective dose of 0.1mg/kg p.o. and maximum effect at 4h post-dose[1].

Animal Model:Male Sprague Dawley rats[1]
Dosage:10mg/kg
Administration:P.o.
Result:Produced an increase in seizure threshold over a wide-dose range in the rat maximal electroshock seizure threshold (MEST) test, with a minimum effective dose of 0.1mgkg1 p.o. and maximum effect at 4h post-dose. The level of anticonvulsant activity achieved correlated well with the blood concentrations of SB-271046 (EC50 of 0.16μM) and brain concentrations of 0.01-0.04μM at Cmax.

IC 50

5-HT6 Receptor: 8.92-9.02 (pKi); 5-HT1D Receptor: 6.55 (pKi); 5-HT1A Receptor: 6.35 (pKi); 5-HT1B Receptor: 6.05 (pKi); 5-HT1F Receptor: 5.95 (pKi); 5-HT2A Receptor: 5.62 (pKi); 5-HT2B Receptor: 5.41 (pKi); 5-HT7 Receptor: 5.39 (pKi); 5-HT4 Receptor: 5.27 (pKi); 5-HT1E Receptor: <4.99 (pKi); Human 5-HT2C Receptor: 5.73 (pKi)

storage

Desiccate at RT

5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride Suppliers

Global Suppliers ( 62)
Supplier Tel Email Country ProdList Advantage
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2374 58
SPIRO PHARMA eric_feng1954@126.com China 9239 55
Henan CoreyChem Co., Ltd 0371-86658258 info@coreychem.com China 10442 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Guangzhou QiYun Biotechnology Co., Ltd. 020-61288194 61288195 505721671@qq.com China 3853 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686 sales@rechemscience.com China 2969 58
Supplier Advantage
Chembest Research Laboratories Limited 61
Hangzhou Sage Chemical Co., Ltd. 58
Haoyuan Chemexpress Co., Ltd. 61
LETOPHARM LIMITED 58
SPIRO PHARMA 55
Henan CoreyChem Co., Ltd 58
Shanghai EFE Biological Technology Co., Ltd. 58
Guangzhou QiYun Biotechnology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Rechem science Co., Ltd. 58

View Latest Price from 5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SB 271046 hydrochloride pictures 2026-07-15 SB 271046 hydrochloride
209481-24-3
 $32.00-133.00 99.77% 10g TargetMol Chemicals Inc.

5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride Spectrum

5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride(209481-24-3)1HNMR

209481-24-3 (5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride) Related Search:

3-Methylbenzyl chloride N-Methoxyphthalimide 4-Methoxybenzylchloride 3-Methoxybenzyl chloride 5-Methyl-N,N-dimethyltryptamine
N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)-benzenesulfonamide hydrochloride

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5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride SB 271046A Benzo[b]thiophene-2-sulfonaMide, 5-chloro-N-[4-Methoxy-3-(1-piperazinyl)phenyl]-3-Methyl-, Monohydrochloride 5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzo-thiophenesulfonamide hydrochloride 4-[(3-chloro-1,4-dioxonaphthalen-2-yl)amino]benzenesulfonamide SB 271046A; SB-271046A SB-271046A >=98% (HPLC) SB 271046 HCl (SB-271046A) oral,test,Serotonin Receptor,SB271046,5-HT Receptor,Inhibitor,inhibit,5-hydroxytryptamine Receptor,SB-271046,SB 271046 hydrochloride,SB 271046,channels,anticonvulsant,selective,MEST SB 271046 hydrochloride, 5-HT6 antagonist SB 271046 hydrochloride, 10 mM in DMSO 209481-24-3 C20H22ClN3O3S2HCl