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Oxazole-2-amine

Oxazole-2-amine structure

CAS No.: 4570-45-0

Chemical Name:: Oxazole-2-amine

Synonyms: oxazol-2-amine;2-AMINO-OXAZOLE;2-OxazolaMine;2-AMINOXAZOLE;Oxazole-2-amine;OXAZOL-2-YLAMINE;OXAZOLE-2-YLAMINE;1,3-OXAZOL-2-AMINE;2-Aminooxazole >2-Aminooxazole,97%

CBNumber:: CB8262819

Molecular Formula:: C3H4N2O

Molecular Weight:: 84.08

MDL Number:: MFCD07364485

MOL File:: 4570-45-0.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:47

Product description	Number	Pack Size	Price
2-Aminooxazole 97%	739731	500mg	$116
2-Aminooxazole >98.0%(GC)(T)	A2884	1g	$128
2-Aminooxazole >98.0%(GC)(T)	A2884	5g	$511
2-Aminooxazole	A618745	500mg	$80
2-Aminooxazole	A618745	100mg	$50
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Oxazole-2-amine Properties

Melting point	93-95℃
Boiling point	186.7±23.0 °C(Predicted)
Density	1.241±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO (Soluble), Ethyl Acetate (Slightly)
form	Solid
pka	5.45±0.10(Predicted)
color	Off-White to Pale Yellow
λmax	219nm(MeOH)(lit.)
InChI	InChI=1S/C3H4N2O/c4-3-5-1-2-6-3/h1-2H,(H2,4,5)
InChIKey	ACTKAGSPIFDCMF-UHFFFAOYSA-N
SMILES	O1C=CN=C1N
CAS DataBase Reference	4570-45-0(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

34-36/37/38

Safety Statements

26-36/37/39-45-24/25

RIDADR

2735

WGK Germany

HazardClass

IRRITANT

HS Code

29349990

NFPA 704

	1
2		0

Oxazole-2-amine price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	739731	2-Aminooxazole 97%	4570-45-0	500mg	$116	2025-07-31	Buy
TCI Chemical	A2884	2-Aminooxazole >98.0%(GC)(T)	4570-45-0	1g	$128	2024-03-01	Buy
TCI Chemical	A2884	2-Aminooxazole >98.0%(GC)(T)	4570-45-0	5g	$511	2023-06-20	Buy
TRC	A618745	2-Aminooxazole	4570-45-0	500mg	$80	2021-12-16	Buy
TRC	A618745	2-Aminooxazole	4570-45-0	100mg	$50	2021-12-16	Buy

Product number	Packaging	Price	Buy
739731	500mg	$116	Buy
A2884	1g	$128	Buy
A2884	5g	$511	Buy
A618745	500mg	$80	Buy
A618745	100mg	$50	Buy

Oxazole-2-amine Chemical Properties,Uses,Production

Uses

2-Aminooxazole is a chemical reagent used in the synthesis of novel inhibitors of the kinetoplastid Trypanosoma brucei.

Synthesis

420-04-2

141-46-8

4570-45-0

Example 2: Preparation of 2-aminooxazole. To a tetrahydrofuran (THF, 60 mL) solution of cyanamide (19.8 mL, 50% w/w aqueous solution, 0.25 mol) was added a 24 mL aqueous solution of 2-hydroxyacetaldehyde (15 g, 0.25 mol). The reaction mixture was treated with 2 M aqueous sodium hydroxide (25.2 mL, 0.05 mol) at 0 °C. The mixture was slowly warmed to room temperature and stirred continuously for 24 hours. Upon completion of the reaction, the volatile solvent (THF) was removed by distillation under reduced pressure. The remaining aqueous solution was extracted with ethyl acetate (4 × 200 mL). The organic phases were combined, dried with anhydrous sodium sulfate, and subsequently concentrated under reduced pressure to give 14.968 g (71.3% yield) of white solid product. The product was characterized by 400 MHz 1H NMR (CDCl3): δ 7.13 (s, 1H), 6.74 (s, 1H), 5.26 (br.s, 2H). Elemental analysis calculated values (C3H4N2O): C 42.86%, H 4.80%, N 33.32%; measured values: C 43.01%, H 4.87%, N 33.11%.

References

[1] Patent: WO2007/123892, 2007, A2. Location in patent: Page/Page column 50
[2] Patent: WO2004/110990, 2004, A2. Location in patent: Page 37
[3] Patent: WO2006/44869, 2006, A1. Location in patent: Page/Page column 132
[4] Chemistry - A European Journal, 2013, vol. 19, # 14, p. 4586 - 4595
[5] Synthesis, 1976, p. 591 - 593

Oxazole-2-amine synthesis

Synthesis of Oxazole-2-amine from Cyanamide and GLYCOLALDEHYDE

Oxazole-2-amine Preparation Products And Raw materials

Raw materials

Sodium sulfate Tetrahydrofuran Diethyl ether Ethyl acetate Sodium hydroxide

PETROLEUM ETHER Cyanamide GLYCOLALDEHYDE 2-Aminoimidazole Ethane, 1,1'-oxybis[1,2-dichloro- (9CI)

mercaptoacetaldehyde Bromoacetaldehyde Bromoacetaldehyde dimethyl acetal Urea Carbamimidothioic acid

Glycolonitrile

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Preparation Products

Idoxuridine

Oxazole-2-amine Suppliers

Global( 190)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2161	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30229	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Baoji Guokang Healthchem Co., Ltd.	+86-0917-3909592 +86-13892490616	gksales1@gk-bio.com	China	9233	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58

Supplier	Advantage
Zhejiang ZETian Fine Chemicals Co. LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
SIMAGCHEM CORP	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Baoji Guokang Healthchem Co., Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Lastest Price from Oxazole-2-amine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-02-23	Oxazole-2-amine 4570-45-0	US $780.00 / g	1g	97	500 Kg	R&D Scientific Inc.
2021-07-13	Oxazole-2-amine 4570-45-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	Oxazole-2-amine 4570-45-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Oxazole-2-amine
4570-45-0
US $780.00 / g
97
R&D Scientific Inc.

Oxazole-2-amine
4570-45-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Oxazole-2-amine
4570-45-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Oxazole-2-amine Spectrum

Oxazole-2-amine(4570-45-0)¹HNMR

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Zoxazolamine 5-PHENYL-OXAZOL-2-YLAMINE 2-HYDRAZINO-1,3-BENZOXAZOLE

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2-AMINO-OXAZOLE 1,3-OXAZOL-2-AMINE 2-Amino-1,3-oxazole 2-AMINOXAZOLE OXAZOLE-2-YLAMINE Oxazole-2-amine OXAZOL-2-YLAMINE oxazol-2-amine 2-Amino Oxazole Or 1,3-Oxazol-2-amine 2-OxazolaMine 2,3-dihydro-1,3-oxazol-2-amine 2-Aminooxazole > 2-Aminooxazole,97% 2-Oxazolamine (9CI, ACI) 4570-45-0 C3H4N20 Amines Oxazoles, Isoxazoles & Benzoxazoles Naphthyridine,Quinoline Oxazoles, Isoxazoles & Benzoxazoles Building Blocks Oxazole