Oxazole-2-amine
- CAS No.
- 4570-45-0
- Chemical Name:
- Oxazole-2-amine
- Synonyms
- oxazol-2-amine;2-AMINO-OXAZOLE;2-OxazolaMine;2-AMINOXAZOLE;1,3-OXAZOL-2-AMINE;Oxazole-2-amine;OXAZOL-2-YLAMINE;OXAZOLE-2-YLAMINE;2-Aminooxazole,97%;2-Aminooxazole >
- CBNumber:
- CB8262819
- Molecular Formula:
- C3H4N2O
- Molecular Weight:
- 84.08
- MDL Number:
- MFCD07364485
- MOL File:
- 4570-45-0.mol
- MSDS File:
- SDS
| Melting point | 93-95℃ |
|---|---|
| Boiling point | 186.7±23.0 °C(Predicted) |
| Density | 1.241±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Soluble), Ethyl Acetate (Slightly) |
| form | Solid |
| pka | 5.45±0.10(Predicted) |
| color | Off-White to Pale Yellow |
| λmax | 219nm(MeOH)(lit.) |
| InChI | InChI=1S/C3H4N2O/c4-3-5-1-2-6-3/h1-2H,(H2,4,5) |
| InChIKey | ACTKAGSPIFDCMF-UHFFFAOYSA-N |
| SMILES | O1C=CN=C1N |
| CAS DataBase Reference | 4570-45-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 34-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-45-24/25 | |||||||||
| RIDADR | 2735 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Oxazole-2-amine price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 739731 | 2-Aminooxazole 97% | 4570-45-0 | 500mg | $124 | 2026-04-30 | Buy |
| TCI Chemical | A2884 | 2-Aminooxazole >98.0%(GC)(T) | 4570-45-0 | 1g | $128 | 2024-03-01 | Buy |
| TCI Chemical | A2884 | 2-Aminooxazole >98.0%(GC)(T) | 4570-45-0 | 5g | $511 | 2023-06-20 | Buy |
| Usbiological | 286259 | Oxazole-2-amine Asreported | 4570-45-0 | 1g | $333 | 2026-06-03 | Buy |
| Usbiological | 286259 | Oxazole-2-amine Asreported | 4570-45-0 | 2g | $480 | 2026-06-03 | Buy |
Oxazole-2-amine Chemical Properties, Uses, Production
Uses
2-Aminooxazole is a chemical reagent used in the synthesis of novel inhibitors of the kinetoplastid Trypanosoma brucei.
Synthesis
420-04-2
141-46-8
4570-45-0
Example 2: Preparation of 2-aminooxazole. To a tetrahydrofuran (THF, 60 mL) solution of cyanamide (19.8 mL, 50% w/w aqueous solution, 0.25 mol) was added a 24 mL aqueous solution of 2-hydroxyacetaldehyde (15 g, 0.25 mol). The reaction mixture was treated with 2 M aqueous sodium hydroxide (25.2 mL, 0.05 mol) at 0 °C. The mixture was slowly warmed to room temperature and stirred continuously for 24 hours. Upon completion of the reaction, the volatile solvent (THF) was removed by distillation under reduced pressure. The remaining aqueous solution was extracted with ethyl acetate (4 × 200 mL). The organic phases were combined, dried with anhydrous sodium sulfate, and subsequently concentrated under reduced pressure to give 14.968 g (71.3% yield) of white solid product. The product was characterized by 400 MHz 1H NMR (CDCl3): δ 7.13 (s, 1H), 6.74 (s, 1H), 5.26 (br.s, 2H). Elemental analysis calculated values (C3H4N2O): C 42.86%, H 4.80%, N 33.32%; measured values: C 43.01%, H 4.87%, N 33.11%.
References
[1] Patent: WO2007/123892, 2007, A2. Location in patent: Page/Page column 50
[2] Patent: WO2004/110990, 2004, A2. Location in patent: Page 37
[3] Patent: WO2006/44869, 2006, A1. Location in patent: Page/Page column 132
[4] Chemistry - A European Journal, 2013, vol. 19, # 14, p. 4586 - 4595
[5] Synthesis, 1976, p. 591 - 593
Oxazole-2-amine Preparation Products And Raw materials
Raw materials
1of4
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin Yao Technology Development Co., Ltd. | 022-18902014291 18902014291 | byswxsb01@163.com | China | 98 | 58 |
| goldenchemical | 18651817751 | xisiyu@goldenchemical.com | China | 1441 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| SelectLab Chemicals GmbH | +49-(0)2383-919350 | info@selectlab.de | Germany | 393 | 55 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
View Latest Price from Oxazole-2-amine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2024-02-23 | Oxazole-2-amine
4570-45-0
|
$780.00 | 1g | 97 | 500 Kg | R&D Scientific Inc. | |
 |
2021-07-13 | Oxazole-2-amine
4570-45-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | Oxazole-2-amine
4570-45-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Oxazole-2-amine
4570-45-0
- $780.00
- 97
- R&D Scientific Inc.
-
- Oxazole-2-amine
4570-45-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Oxazole-2-amine
4570-45-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
