Famoxadone
- CAS No.
- 131807-57-3
- Chemical Name:
- Famoxadone
- Synonyms
- Famoxadon;JE 874;Famoxate;CCharisma;IN-JE 874;DPX-JE 874;FAMOXADONE;60%Famoxadone;30%Famoxadone;50%Famoxadone
- CBNumber:
- CB8439206
- Molecular Formula:
- C22H18N2O4
- Molecular Weight:
- 374.39
- MDL Number:
- MFCD03427409
- MOL File:
- 131807-57-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 140.3~141.8℃ |
|---|---|
| Boiling point | 491.3±55.0 °C(Predicted) |
| Density | 1.327±0.06 g/cm3(Predicted) |
| vapor pressure | 6.4 x 10-7 Pa (20 °C) |
| Flash point | 2 °C |
| storage temp. | 0-6°C |
| solubility | DMSO: 100 mg/mL (267.10 mM) |
| Water Solubility | 0.243 mg-1 (pH 5), 0.011 mg l-1 (pH 7) at 20 °C |
| pka | 0.63±0.40(Predicted) |
| form | Solid:particulate/powder |
| color | White to yellow |
| Henry's Law Constant | 2.1×102 mol/(m3Pa) at 25℃, HSDB (2015) |
| Major Application | agriculture |
| InChI | InChI=1S/C22H18N2O4/c1-22(16-12-14-19(15-13-16)27-18-10-6-3-7-11-18)20(25)24(21(26)28-22)23-17-8-4-2-5-9-17/h2-15,23H,1H3 |
| InChIKey | PCCSBWNGDMYFCW-UHFFFAOYSA-N |
| SMILES | O1C(C)(C2=CC=C(OC3=CC=CC=C3)C=C2)C(=O)N(NC2=CC=CC=C2)C1=O |
| LogP | 4.65-5.08 at 20℃ and pH4-7 |
| Surface tension | 73mN/m at 90μg/L and 20.4℃ |
| EWG's Food Scores | 1 |
| FDA UNII | V1C07OR6II |
| EPA Substance Registry System | Famoxadone (131807-57-3) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H302-H312-H319-H332 |
| Precautionary statements | P210-P280-P305+P351+P338 |
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter |
| Hazard Codes | Xn,N,F |
| Risk Statements | 48/22-50/53-36-20/21/22-11 |
| Safety Statements | 46-60-61-36-26-16-36/37 |
| RIDADR | UN1648 3/PG 2 |
| WGK Germany | 2 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 2 |
| Hazardous Substances Data | 131807-57-3(Hazardous Substances Data) |
| Toxicity | LD50 in rats (mg/kg): >5000 orally; >2000 dermally (Joshi, Sternberg) |
| REACH Registrations | Active |
Famoxadone price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 33495 | Famoxadone solution 100?μg/mL in acetonitrile, PESTANAL?, analytical standard | 131807-57-3 | 2ML | $94.2 | 2026-04-30 | Buy |
| TCI Chemical | F1206 | Famoxadone | 131807-57-3 | 1G | $85 | 2026-04-30 | Buy |
| TCI Chemical | F1206 | Famoxadone | 131807-57-3 | 5G | $253 | 2026-04-30 | Buy |
| Cayman Chemical | 34470 | Famoxadone ≥98% | 131807-57-3 | 25mg | $37 | 2026-04-30 | Buy |
| Cayman Chemical | 34470 | Famoxadone ≥98% | 131807-57-3 | 50mg | $70 | 2026-04-30 | Buy |
Famoxadone Chemical Properties, Uses, Production
Description
Famoxadone is an oxazolidinedione fungicide. Although famoxadone is not a strobilurin derivative, it shares the same mechanism of action. Famoxadone provides control of a broad spectrum of fungi but is particularly effective against downy mildew (P. viticola), late and early blights (Phytophthora infestans and Alternaria solani), the Septoria complex, and barley net blotch at rates of 50 to 200 g ai/ha. Target crops include vines, potatoes/tomatoes, cereals, sugar beets, canola, and cucumber. It shows good protectant, translaminar and residual control, with excellent rainfastness and good crop safety. As was seen for trifloxystrobin, it is particularly effective against grape downy mildew when applied in mixture with cymoxanil. The cereal disease spectrum and level of disease control are improved when famoxadone is mixed with triazole fungicides such as flusilazole.
Chemical Properties
Brown Solid
Uses
Famoxadone is a known fungicide used in the protection of agricultural products against various fungal diseases and other biotic stresses such as pests.
Uses
Agricultural fungicide.
Uses
Famoxadone provides preventive control of a broad spectrum of fungal pathogens such as Plasmopara viticola (grape downy mildew), Phytophthora infestans (potato/ tomato late blight), Pseudoperonospora cubensis (cucumber downy mildew), Septoria tritici (wheat leaf blotch), S. nodorum (wheat glume blotch) and Alternaria solani (potato/tomato early blight).
Definition
ChEBI: 5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-1,3-oxazolidine-2,4-dione is a member of the class of oxazolidinones that is 1,3-oxazolidine-2,4-dione in which the hydrogen attached to the nitrogen is substituted by a phenylamino group and the hydrogens at position 5 are substituted by methyl and 4-phenoxyphenyl groups. It is an aromatic ether, a carbohydrazide and an oxazolidinone.
Production Methods
Famoxadone is commercially produced through a multi-step chemical synthesis that begins with the formation of its oxazolidinedione core structure. The process involves the reaction of 3-anilino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione, combining aromatic and heterocyclic components to achieve the final fungicidal compound. This synthesis is typically carried out in closed chemical production systems to minimise exposure and environmental release, adhering to strict containment protocols.
Agricultural Uses
Fungicide: Tanos 50-DF is recommended for use as a preventative fungicide for control of late blight and early blight on potatoes and field tomatoes.
Trade name
DPX-JE874®; FAMOXATE®; MEDLEY®; TANOS-50DF®
Mechanism of action
Protectant with residual activity. Respiration inhibitor (QoL fungicide). Inhibits fungal mitochondrial respiration (at complex III), resulting in decreased ATP production. It is active against zoospore germination and mycelial growth.
Pharmacology
Famoxadone inhibits activity of ubiquinol : cytochrome c oxidoreductase at the Qo site of complex III, the same target protein as the strobilurins (34,35). However, studies show a difference in the potency of various strobilurins compared with famoxadone in single amino acid mutants of the cytochrome b protein, suggesting that this compound may interact differently with the target protein (38).
Metabolic pathway
Famoxadone undergoes extensive degradation and metabolism in aqueous and soil environments, in wheat plants, rats, goats and hens via common pathways. The primary reactions include the hydrolytic opening of the oxazolidinedione ring, aryl hydroxylation, cleavage of the phenoxyphenyl and the oxazolidinedione-aminophenyl linkages and conjugation. More than 25 degradation products have been identified.
Degradation
Famoxadone is relatively stable to hydrolytic degradation under dark conditions in pH 5 buffer solution (DT50 41 days) (Jernberg et al., 1998a). It was hydrolysed rapidly at pH 7 and pH 9 at 25 °C (DT50 values 2 days and <2 hours, respectively). No sigruficant sunlight-induced degradation was observed at pH 7. Hydrolytic degradation was catalysed in acidic conditions (pH 5) under natural sunlight (DT50 4.6 days in contrast to 41 days at pH 7). Primary hydrolytic degradation reactions include the opening of the oxazolidinedione ring [to yieldα-hydroxy-α-methyl-4-phenoxyphenylacetic acid 2-phenylhydrazide (2) and 1-carboxy-1-(4-phenoxy-phenyl) ethyl-2-phenylhydrazinecarboxylic acid (3)], and the cleavage of the oxazolidine-aminophenyl linkage to yield various products from both the phenoxyphenyl moiety [ 1-(4-phenoxyphenyl)ethanone (4) and α-hydroxy- α-methyl-4-phenoxyphenylacetiac acid (5)] and the aminophenyl moiety [small amounts of phenol (6), catechol (7) and benzene (8) via the proposed 2-phenylhydrazinecarboxylic acid intermediate (9)] (see Scheme 1).
Toxicity evaluation
Famoxadone has an acute oral LD50 > 5,000 mg/kg and an acute percutaneous LD50 > 2,000 mg/kg in rats. It is not a skin or eye irritant, is negative in the Ames test, and is nonteratogenic. It shows very little soil degradation, is nonmobile, and has a good ecotoxicological profile.
Pesticide Type
Fungicide
Famoxadone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Linglingjiu Biotechnology Co., Ltd | 15623309010 | 1287744812@qq.com | China | 960 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Rudong Zhongyi Chemical Co., Ltd | 13306234115 | jszyzj@zhongyichem.com | China | 36 | 60 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
View Latest Price from Famoxadone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | Famoxadone
131807-57-3
|
100KG | 98 | 200TONS | Qingdao Trust Agri Chemical Co.,Ltd | ||
 |
2026-06-10 | Famoxadone
131807-57-3
|
$56.00 | 98.35% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-18 | Famoxadone
131807-57-3
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd |
-
- Famoxadone
131807-57-3
- $0.00
- 98
- Qingdao Trust Agri Chemical Co.,Ltd
-
- Famoxadone
131807-57-3
- $56.00
- 98.35%
- TargetMol Chemicals Inc.
-
- Famoxadone
131807-57-3
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
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