PSI 7851
- CAS No.
- 1064684-44-1
- Chemical Name:
- PSI 7851
- Synonyms
- GS9851;GS 9851;CS-1996;GS-9851;PSI 7851;PSI-7977, SOFOSBUVIR;5'-O-(isopropyl-L-alanate,phenyl-phosphoramidyl)-2'-deoxy-2'-fluoro-2'-C-methyl-uridine;N-[(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester;L-Alanine, N-[(2'R)-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl ester;(2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate (Sofosbuvir Impurity）
- CBNumber:
- CB82628299
- Molecular Formula:
- C22H29FN3O9P
- Molecular Weight:
- 529.45
- MDL Number:
- MOL File:
- 1064684-44-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Psi-7977 95% | AA00HAQN | 250mg | $1229 |
| Psi-7977 95% | AA00HAQN | 1g | $1328 |
| PSI-7977 97% | CD70002692 | 1g | $465 |
| PSI-7977 97% | CD70002692 | 5g | $1632 |
| More product size | |||
| Density | 1.41±0.1 g/cm3(Predicted) |
|---|---|
| pka | 9.39±0.10(Predicted) |
| FDA UNII | 3S5S1851OV |
PSI 7851 price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA00HAQN | Psi-7977 95% | 1064684-44-1 | 250mg | $1229 | 2026-05-28 | Buy |
| aablocks | AA00HAQN | Psi-7977 95% | 1064684-44-1 | 1g | $1328 | 2026-05-28 | Buy |
| Crysdot | CD70002692 | PSI-7977 97% | 1064684-44-1 | 1g | $465 | 2026-05-27 | Buy |
| Crysdot | CD70002692 | PSI-7977 97% | 1064684-44-1 | 5g | $1632 | 2026-05-27 | Buy |
PSI 7851 Chemical Properties,Uses,Production
Uses
GS-9851 (PSI-7851) is an HCV nonstructural protein 5B (NS5B) inhibitor with potential activity for the treatment of HCV infection. GS-9851 showed good tolerability in patients with initial HCV genotype 1 infection. GS-9851 is rapidly cleared from the body with a half-life of approximately 1 hour. The maximum concentration of GS-9851 and the increase in the area under the compound concentration-time curve were not dose-proportional, especially at the highest dose[1].
References
[1] Pharmacokinetics, pharmacodynamics, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor, following multiple ascending doses in patients with chronic hepatitis C infection
[2] Discovery of a β-D-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus
J. Med. Chem., Article ASAP
DOI: 10.1021/jm100863x
Publication Date (Web): September 16, 2010
PSI 7851 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32468 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9653 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +86-18949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49895 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 6747 | 65 |
