(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one
- CAS No.
- 39777-61-2
- Chemical Name:
- (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one
- Synonyms
- TFEB activator 1;RPN77612;Curcumin analog C1;Curcumin analog compound C1;TFEB activator 1, 10 mM in DMSO;Curcumin analog C1(TFEB activator 1 );(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1;1,5-Bis-(2-methoxy-phenyl)-penta-1,4-dien-3-one;(1E,4E)-1,5-bis(2-methoxy)-1,4-dienyl-3-pentanone;(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one
- CBNumber:
- CB82631480
- Molecular Formula:
- C19H18O3
- Molecular Weight:
- 294.35
- MDL Number:
- MFCD00719180
- MOL File:
- 39777-61-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 120-122 °C(Solv: ethanol (64-17-5); water (7732-18-5)) |
|---|---|
| Boiling point | 467.2±40.0 °C(Predicted) |
| Density | 1.128±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 125 mg/mL (424.68 mM) |
| form | A solid |
| color | Light yellow to yellow |
| InChI | InChI=1S/C19H18O3/c1-21-18-9-5-3-7-15(18)11-13-17(20)14-12-16-8-4-6-10-19(16)22-2/h3-14H,1-2H3/b13-11+,14-12+ |
| InChIKey | RCZMPCUUTSDNAJ-PHEQNACWSA-N |
| SMILES | C(/C1=CC=CC=C1OC)=C\C(=O)/C=C/C1=CC=CC=C1OC |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319-H315-H335 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C3883 | Curcumin Analog C1 | 39777-61-2 | 25MG | $100 | 2026-04-30 | Buy |
| Cayman Chemical | 34255 | Curcumin analog C1 ≥98% | 39777-61-2 | 1mg | $31 | 2026-04-30 | Buy |
| Cayman Chemical | 34255 | Curcumin analog C1 ≥98% | 39777-61-2 | 5mg | $107 | 2026-04-30 | Buy |
| Cayman Chemical | 34255 | Curcumin analog C1 ≥98% | 39777-61-2 | 10mg | $183 | 2026-04-30 | Buy |
| Cayman Chemical | 34255 | Curcumin analog C1 ≥98% | 39777-61-2 | 25mg | $304 | 2026-04-30 | Buy |
(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one Chemical Properties, Uses, Production
Uses
TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and has the potential for neurodegenerative diseases treatment[1].
in vivo
The medium lethal dose (LD50) value of TFEB activator 1 (Compound C1) is 175 mg/kg in the acute toxicity assay (single-dose i.v. tail vein injection; in rats) [1].
Short-term oral administration of TFEB activator 1 (low dosage 10 mg/kg and high dosage 25 mg/kg; for 24 h) dose-dependently increases the expression of LC3B-II and TFEB in the liver, frontal cortex and striatum of the brain[1].
Chronic administration of TFEB activator 1 (10 mg/kg per day; orally administered by gavage) activates TFEB and enhances autophagy in rat brains[1].
| Animal Model: | Adult male Sprague-Dawley (SD) rats weighing 350 to 400 g[1] |
| Dosage: | 10 mg/kg and 25 mg/kg |
| Administration: | Short-term oral administration; for 24 hours |
| Result: | Activated TFEB and enhanced autophagy and lysosome biogenesis in rat brain. |
| Animal Model: | Adult male Sprague-Dawley (SD) rats weighing 350 to 400 g[1] |
| Dosage: | 10 mg/kg |
| Administration: | Chronic oral administration; daily; for 21 days |
| Result: | Activated TFEB and enhanced autophagy in rat brains. |
References
[1] Song JX, et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016 Aug 2;12(8):1372-89. DOI:10.1080/15548627.2016.1179404
(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one Preparation Products And Raw materials
Raw materials
Preparation Products
(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6745 | 58 |
| Qingyuan Stephen Catalyst Co., Ltd. | 18316607267 | 285452@163.com | China | 216 | 58 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2969 | 58 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Guangzhou Zhiya Chemdrugs Co.,Ltd | 18122150900 | sculk28@163.com | China | 645 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16021 | 58 |
| Henan Alfachem Co.,Ltd. | 0371-55051623 18137891487 | 3983243027@qq.com | China | 9974 | 58 |
View Latest Price from (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-16 | TFEB activator 1
39777-61-2
|
$35.00-85.00 | 99.77% | 10g | TargetMol Chemicals Inc. |
-
- TFEB activator 1
39777-61-2
- $35.00-85.00
- 99.77%
- TargetMol Chemicals Inc.
