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InvivoChem Gold |
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13549236410 |
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(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one manufacturers
- TFEB activator 1
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- $35.00
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2026-07-16
- CAS:39777-61-2
- Purity: 99.77%
- Supply Ability: 10g
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| | (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one Basic information |
| Product Name: | (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one | | Synonyms: | (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one;1,4-Pentadien-3-one, 1,5-bis(2-Methoxyphenyl)-, (1E,4E)-;Curcumin analog C1;1,5-Bis-(2-methoxy-phenyl)-penta-1,4-dien-3-one;(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1;Curcumin analog compound C1;RPN77612;(1E,4E)-1,5-Bis(2-methoxyphenyl)-1,4-pentadien-3-one | | CAS: | 39777-61-2 | | MF: | C19H18O3 | | MW: | 294.35 | | EINECS: | | | Product Categories: | | | Mol File: | 39777-61-2.mol |  |
| | (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one Chemical Properties |
| Melting point | 120-122 °C(Solv: ethanol (64-17-5); water (7732-18-5)) | | Boiling point | 467.2±40.0 °C(Predicted) | | density | 1.128±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 125 mg/mL (424.68 mM) | | form | A solid | | color | Light yellow to yellow | | InChI | InChI=1S/C19H18O3/c1-21-18-9-5-3-7-15(18)11-13-17(20)14-12-16-8-4-6-10-19(16)22-2/h3-14H,1-2H3/b13-11+,14-12+ | | InChIKey | RCZMPCUUTSDNAJ-PHEQNACWSA-N | | SMILES | C(/C1=CC=CC=C1OC)=C\C(=O)/C=C/C1=CC=CC=C1OC |
| | (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one Usage And Synthesis |
| Uses | TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and has the potential for neurodegenerative diseases treatment[1]. | | in vivo | The medium lethal dose (LD50) value of TFEB activator 1 (Compound C1) is 175 mg/kg in the acute toxicity assay (single-dose i.v. tail vein injection; in rats) [1].
Short-term oral administration of TFEB activator 1 (low dosage 10 mg/kg and high dosage 25 mg/kg; for 24 h) dose-dependently increases the expression of LC3B-II and TFEB in the liver, frontal cortex and striatum of the brain[1].
Chronic administration of TFEB activator 1 (10 mg/kg per day; orally administered by gavage) activates TFEB and enhances autophagy in rat brains[1]. | Animal Model: | Adult male Sprague-Dawley (SD) rats weighing 350 to 400 g[1] | | Dosage: | 10 mg/kg and 25 mg/kg | | Administration: | Short-term oral administration; for 24 hours | | Result: | Activated TFEB and enhanced autophagy and lysosome biogenesis in rat brain. |
| Animal Model: | Adult male Sprague-Dawley (SD) rats weighing 350 to 400 g[1] | | Dosage: | 10 mg/kg | | Administration: | Chronic oral administration; daily; for 21 days | | Result: | Activated TFEB and enhanced autophagy in rat brains. |
| | References | [1] Song JX, et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016 Aug 2;12(8):1372-89. DOI:10.1080/15548627.2016.1179404 |
| | (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one Preparation Products And Raw materials |
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