1-Boc-5-Ethyl-2,4-dioxopiperidine
- CAS No.
- 845267-80-3
- Chemical Name:
- 1-Boc-5-Ethyl-2,4-dioxopiperidine
- Synonyms
- 1-Boc-5-Ethyl-2,4-dioxopiperidine;1-Boc-5-ethyl-2, 4-piperidinedione;1-Boc-5-ethyl-2, 4-piperidinedione - [E14289];tert-butyl 5-ethyl-2,4-dioxopiperidine-1-carboxylate;1-Piperidinecarboxylic acid, 5-ethyl-2,4-dioxo-, 1,1-dimethylethyl ester
- CBNumber:
- CB82638409
- Molecular Formula:
- C12H19NO4
- Molecular Weight:
- 241.28
- MDL Number:
- MFCD19689659
- MOL File:
- 845267-80-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
1-Boc-5-Ethyl-2,4-dioxopiperidine price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 123992 | 1-Boc-5-ethyl-2 4-piperidinedione | 845267-80-3 | 1.00g | $479 | 2026-05-18 | Buy |
| Synthonix | E14289 | 1-Boc-5-ethyl-2, 4-piperidinedione 95+% | 845267-80-3 | 1g | $140 | 2026-05-06 | Buy |
| Synthonix | E14289 | 1-Boc-5-ethyl-2, 4-piperidinedione 95+% | 845267-80-3 | 5g | $420 | 2026-05-06 | Buy |
| Synthonix | E14289 | 1-Boc-5-ethyl-2, 4-piperidinedione 95+% | 845267-80-3 | 10g | $690 | 2026-05-06 | Buy |
| aablocks | AA0053U1 | Tert-Butyl 5-Ethyl-2,4-Dioxopiperidine-1-Carboxylate 95% | 845267-80-3 | 250mg | $74 | 2026-05-28 | Buy |
1-Boc-5-Ethyl-2,4-dioxopiperidine Chemical Properties, Uses, Production
Synthesis
845267-78-9
75-03-6
845267-80-3
General procedure for the synthesis of 1-Boc-5-ethyl-2,4-dioxopiperidine from tert-butyl 2,4-dioxopiperidine-1-carboxylate and ethyl iodide: tert-butyl-2,4-dioxopiperidine-1-carboxylate (1.92 g, 9.0 mmol) was dissolved in anhydrous tetrahydrofuran (THF, 65 mL) under nitrogen protection, and cooled to -20°C. The reaction was carried out under nitrogen protection. Lithium bis(trimethylmethylsilyl)amide (LiHMDS, 1 M THF solution, 27 mL) was added slowly and dropwise. After stirring the reaction mixture for 20 minutes, ethyl iodide (2.53 mL, 4.9 g, 31.3 mmol) was added and stirring was continued at -20 °C for 2 hours. After completion of the reaction, the mixture was poured into 5% aqueous potassium bisulfate (KHSO4) and extracted with dichloromethane (DCM, 2×). The organic layers were combined, washed with water, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by column chromatography (hexane/ethyl acetate, 1:1) to give 1.4 g of the target product (5.8 mmol, 64% yield). Electrospray ionization mass spectrometry (ESI-MS) showed m/z 242 ([M+H]+).
References
[1] Patent: WO2005/13986, 2005, A1. Location in patent: Page/Page column 43
[2] Patent: WO2005/14572, 2005, A1. Location in patent: Page/Page column 34
[3] Patent: US2007/142414, 2007, A1. Location in patent: Page/Page column 18
[4] Synthesis, 2007, # 20, p. 3185 - 3190
1-Boc-5-Ethyl-2,4-dioxopiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
1-Boc-5-Ethyl-2,4-dioxopiperidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Hangzhou Molcore Biopharmatech Co.,Ltd | 400-711-5280 86-571-81025280 | sales@molcore.com | China | 9957 | 58 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15078 | 58 |
| Suzhou Nuoouman Biological Technology Co., Ltd. | 15026866316 | 180642609@qq.com | China | 4966 | 58 |
| Shanghai Hanlin biology science and technology co., ltd | 183-0212-4410 18302124410 | Djt18302124410@163.com | China | 2869 | 58 |
| Hubei Co-prosperity Medicine Technonlogy Co., Ltd | 2383948258 19172820304 | 2383948258@qq.com | China | 12983 | 58 |
| Shanxi Nuocheng Biotechnology Co., Ltd | 17835231871 | 572710841@qq.com | China | 7939 | 58 |
| Sichuan BoYou Biotechnology Co., Ltd. | 028-65791793 18140026355 | 568470422@qq.com | China | 8965 | 58 |
| Nanjing SynTitan Pharmaceutical Co., Ltd. | 25-57027686 17372956142 | li_lan@syntitan.com | China | 8000 | 58 |
