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Lithium bis(trimethylsilyl)amide

Lithium bis(trimethylsilyl)amide Structure
Lithium bis(trimethylsilyl)amide structure
CAS No.
4039-32-1
Chemical Name:
Lithium bis(trimethylsilyl)amide
Synonyms
LIHMDS;LHMDS;LITHIUM HEXAMETHYLDISILAZANE;LITHIUM HEXAMETHYLDISILAZIDE;Lithium bis(trimethylsilyl)amide solution;HMDS Li;LiHMDS（1M）;N-LITHIOHEXAMETHYLDISILAZANE;1,1,1,3,3,3-HEXAMETHYLDISILAZAN LITHIUMSALZ;1,1,1,3,3,3-HEXAMETHYLDISILAZANE LITHIUM SALT
CBNumber:
CB2202677
Molecular Formula:
C6H18LiNSi2
Molecular Weight:
167.33
MDL Number:
MFCD00008261
MOL File:
4039-32-1.mol
MSDS File:
SDS
Last updated:2026-01-13 11:17:59
Product description Number Pack Size Price
Lithium bis(trimethylsilyl)amide 99.9% trace metals basis 920398 1 g $30.4
Lithium bis(trimethylsilyl)amide 99.9% trace metals basis 920398 25 g $73
Lithium bis(trimethylsilyl)amide 99.9% trace metals basis 920398 100 g $243
Lithium bis(trimethylsilyl)amide solution 1.0?M in THF 225770 18L $2900
Lithium bis(trimethylsilyl)amide solution 1.0 M in hexanes 224367 100ml $104
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Lithium bis(trimethylsilyl)amide Properties

Melting point 73°C
Boiling point 55-56 °C
Density 0.860 g/mL at 25 °C (lit.)
refractive index n20/D 1.425(lit.)
Flash point 48 °F
storage temp. Store below +30°C.
solubility hydrolysis
form Powder
color White
Specific Gravity 0.716
Water Solubility hydrolysis
Hydrolytic Sensitivity 8: reacts rapidly with moisture, water, protic solvents
Sensitive Air & Moisture Sensitive
BRN 3567910
Exposure limits ACGIH: TWA 50 ppm; STEL 100 ppm (Skin)
OSHA: TWA 200 ppm(590 mg/m3)
NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3)
Major Application battery precursors
catalysts
material synthesis precursor
InChI 1S/C6H18NSi2.Li/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1
InChIKey YNESATAKKCNGOF-UHFFFAOYSA-N
SMILES [Li]N([Si](C)(C)C)[Si](C)(C)C
CAS DataBase Reference 4039-32-1(CAS DataBase Reference)
FDA UNII RC4N1I108M
EPA Substance Registry System Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, lithium salt (4039-32-1)
UNSPSC Code 12352111
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS05
Signal word  Danger
Hazard statements  H228-H251-H314
Precautionary statements  P210-P235-P260-P280-P303+P361+P353-P305+P351+P338
Hazard Codes  F,C,N
Risk Statements  11-34-48/20-63-65-67-51/53-35-20-62-14-40-37-19
Safety Statements  9-16-26-29-33-36/37/39-45-61-62-57-43
RIDADR  UN 2925 4.1/PG 2
WGK Germany  3
F  10-23
TSCA  TSCA listed
HazardClass  4.3
PackingGroup  II
HS Code  29319090
Storage Class 4.2 - Pyrophoric and self-heating hazardous materials
Hazard Classifications Eye Dam. 1
Flam. Sol. 1
Self-heat. 1
Skin Corr. 1B
Limited Quantities 1.0 L (0.3 gallon) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
3
3 2
W

Lithium bis(trimethylsilyl)amide price More Price(60)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 920398 Lithium bis(trimethylsilyl)amide 99.9% trace metals basis 4039-32-1 1 g $30.4 2025-07-31 Buy
Sigma-Aldrich 920398 Lithium bis(trimethylsilyl)amide 99.9% trace metals basis 4039-32-1 25 g $73 2025-07-31 Buy
Sigma-Aldrich 920398 Lithium bis(trimethylsilyl)amide 99.9% trace metals basis 4039-32-1 100 g $243 2025-07-31 Buy
Sigma-Aldrich 225770 Lithium bis(trimethylsilyl)amide solution 1.0?M in THF 4039-32-1 18L $2900 2025-07-31 Buy
Sigma-Aldrich 224367 Lithium bis(trimethylsilyl)amide solution 1.0 M in hexanes 4039-32-1 100ml $104 2025-07-31 Buy
Product number Packaging Price Buy
920398 1 g $30.4 Buy
920398 25 g $73 Buy
920398 100 g $243 Buy
225770 18L $2900 Buy
224367 100ml $104 Buy

Lithium bis(trimethylsilyl)amide Chemical Properties,Uses,Production

Chemical Properties

light yellow to yellow crystalline powder

Physical properties

distillable low-melting solid; mp 70–72 °C, bp 115 °C/1mmHg. LHMDS is a cyclic trimer in the solid state,3 whereas in benzene solution it exists in a monomer–dimer equilibrium. LHMDS exists as a tetramer-dimer mixture in hydrocarbons and as a dimer-monomer mixture in THF and ether. Treatment of LHMDS with trialkylamines increases the monomer concentration, whereas the use of diamines affords exclusively the corresponding chelated monomer. LHMDS is less soluble, less basic, more stable, and much less sensitive to air compared to lithium diisopropylamide. pKa 29.5 (THF, 27 °C).

Uses

Lithium bis(trimethylsilyl)amide is used as nonnucleophilic base to generate kinetic ketone and ester enolates. It is considerably more selective than LDA and undesired reductions (e.g., of nonenolizable ketones observed in the case of LDA) can be avoided by using LHMDS.

Uses

Lithium Hexamethyldisilazide is widely used as strong nonnucleophilic base

Uses

Lithium bis(trimethylsilyl)amide is a base used in preparation of dienes and enolates. It is used to catalyze the addition of phosphine P-H bonds to carbodiimides leading to phosphaguanidines. Lithium bis(trimethylsilyl)amide is also used in a novel three-step synthesis of disubstituted 1,2,5-thiadiazoles.

Preparation

It is conveniently prepared by the reaction of hexamethyldisilazane with n-butyllithium in hexane. For most uses the hexane is then evaporated and replaced with THF.

General Description

This product, 0.5 M in 2-methyltetrahydrofuran aligns with Safer Solvents and Auxiliaries, Use of Renewable Feedstocks and Inherently Safer Chemistry for Accident Prevention.

Flammability and Explosibility

Highly flammable

Lithium bis(trimethylsilyl)amide Preparation Products And Raw materials

Raw materials

Tetrahydrofuran Hexamethyldisilazane n-Butyllithium

Preparation Products

METHYL-2-CHLOROOXAZOLE-5-CARBOXYLATE N-(Trimethylsilyl)-2,2-dimethylpropane-1-imine o-(Trimethylsilyl)phenol 3-Iodopropanol NONAMETHYLTRISILAZANE
tert-Butoxytrimethylsilane Trimethyl(phenoxy)silane 1,3,2-Dioxaborolane-2-methanamine, 4,4,5,5-tetramethyl-N,N-bis(trimethylsilyl)-

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Lithium bis(trimethylsilyl)amide Suppliers

Global( 494)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8753 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81148696 +86-17392712697 1022@dideu.com China 3995 58
RongNa Biotechnology Co.,Ltd 		+86-86-13583358881 +8618560316533 Brad@rongnabiotech.com China 3378 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5242 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20128 58
Shandong Deshang Chemical Co., Ltd. 		+86-0531-8875-2665 +8613153039501 info@deshangchem.com China 661 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13799 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21597 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
RongNa Biotechnology Co.,Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Henan Fengda Chemical Co., Ltd 		58
Shandong Deshang Chemical Co., Ltd. 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60

Related articles

View Lastest Price from Lithium bis(trimethylsilyl)amide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lithium bis(trimethylsilyl)amide pictures 2026-02-17 Lithium bis(trimethylsilyl)amide
4039-32-1
 US $10.00 / ASSAYS 1ASSAYS 99% 1 ton RongNa Biotechnology Co.,Ltd
Lithium Bis(trimethylsilyl)amide pictures 2026-02-15 Lithium Bis(trimethylsilyl)amide
4039-32-1
 US $0.00 / kg 1kg 98% Customise Hefei Lbao Physical & Chemical Science Co.,Ltd
Lithium bis(trimethylsilyl)amide pictures 2026-01-30 Lithium bis(trimethylsilyl)amide
4039-32-1
 US $10.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd

Lithium bis(trimethylsilyl)amide Spectrum

Lithium bis(trimethylsilyl)amide(4039-32-1)RamanLithium bis(trimethylsilyl)amide(4039-32-1)IR

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1,1,1,3,3,3-HEXAMETHYLDISILAZAN LITHIUMSALZ 1,1,1,3,3,3-HEXAMETHYLDISILAZANE LITHIUM SALT HEXAMETHYLDISILAZANE LITHIUM SALT LHMDS LIHMDS LITHIUM HEXAMETHYLDISILAZANE LITHIUM HEXAMETHYLDISILAZIDE LITHIUM-BIS-(TRIMETHYLSILYL)-AMID LITHIUM BIS(TRIMETHYLSILYL)AMIDE Lithium bis(trimethylsilyl)amide, 0.9-1.1M in hexane, packaged under Argon in resealable ChemSeal bottles Lithium bis(trimethylsilyl)amide, 1.0m solution in methyl tert-butyl ether Lithium bis(trimethylsilyl)amide1.0M sol. in methyl tert-butyl etherAcroSeal§3 Lithium bis(trimethylsilyl)amide1M solution in THF/EthylbenzeneAcroSeal§3 Lithium bis(trimethylsilyl)amide0.9M solution in methylcyclohexaneAcroSeal§3 (Lithioimino)bis(trimethylsilane) [Di(trimethylsilyl)amino] lithium 2-Lithio-1,1,1,3,3,3-hexamethylpropanedisilazane 2-Lithiohexamethylpropanedisilazane Lithioiminobis(trimethylsilane) N-Lithio-N-(trimethylsilyl)-α,α,α-trimethylsilanamine Lithium Hexamethyldisilazide,LiHMDS N-LITHIOHEXAMETHYLDISILAZANE 1,1,1-trimethyl-n-(trimethylsilyl)-silanaminlithiumsalt lithium-bis-(trimethylsilyl)-amide(30%inthf) Lithium bis(trimethylsilyl)amide, 20% (ca 1.06M) soln. in THF/ethylbenzene Lithium bis(trimethylsilyl)amide, 0.9-1.1M in hexane, packaged under Argon in resealable ChemSealTM bottles Lithium Hexamethyldisilazide (29% in Tetrahydrofuran, ca. 1.6mol/L) Lithium bis(trimethylsilyl)amide, 0.9-1.1M in hexane, packaged under Argon in resealable ChemSeal^t bottles Lithium bis(trimethylsilyl)amide, 0.9-1.1M in hexane, packaged under Argon in resealable ChemSeal^t Lithium bis(trimethylsilyl)amide,1.3M solution in toluene/ethylbenzene Lithium bis(trimethylsilyl)amide, 1.3M solution in THF Lithium bis(trimethylsilyl)amide,1.3M solution in hexanes/ethylbenzene LithiuM Bis(triMethylsilyl)aMide (ca. 26% in Tetrahydrofuran, ca. 1.3Mol/L) LithiuM bis(triMethylsilyl)aMide, stab. with hexane Hexamethyldisilazane Lithium Salt LiHMDS Lithium Hexamethyldisilazide LithiuM bis(triMethylsilyl)aMide, 15% in 2-MeTHF/Ethylbenzene, AcroSeal LITHIUM HEXAMETHYLDISILAZIDE, 1.25M in tetrahydrofuran LithiuM bis(triMethylsilyl) aMide, titr 95% LithiuM bis(triMethylsilyl)aMide solution 1.0 M in THF LithiuM bis(triMethylsilyl)aMide, 1.0 M solution in THF LithiuM bis(triMethylsilyl)aMide, 1.0 M solution in THF, J&KSeal HMDS Li LithiuM bis(triMethylsilyl)aMide solution 1 M in toluene LithiuM bis(triMethylsilyl)aMide solution 1.0 M in hexanes LithiuM bis(triMethylsilyl)aMide, 0.5 M solution in toluene, SpcSeal Double triMethyl silyl aMino lithiuM LithiuM bis(triMethylsilyl)aMide, 1.0 M solution in THF, SpcSeal LithiuM bis(triMethylsilyl)aMide, 1.0M solution in Methyl tert-butyl ether, SpcSeal Lithium bis(trimethylsilyl)amide, 1M in THF LiHMDS（1M） N,N-Bis(trimethylsilyl)amidelithium, 97%, 20% THF solution Lithium bis(trimethylsilyl)amide, 1M in toluene Lithium Hexamethyldisilazide (1M in Tetrahydrofuran) Lithium bis(trimethylsilyl)amide, 1.0M sol. in methyl tert-butyl ether Lithium bis(trimethylsilyl)amide, 1M solution in THF/Ethylbenzene Hexamethyldisilazanelithiumsalt24%THF Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, lithium salt lithium bis(trimethylsilyl)amide, 0.9-1.1m in hexane, packaged under argon in resealable chemseal