1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea
![1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea Structure](CAS/20150408/GIF/1155877-97-6.gif)
- CAS No.
- 1155877-97-6
- Chemical Name:
- 1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea
- Synonyms
- D159687;D-159687 - Bio-X ?;D159687, 10 mM in DMSO;D159687; D-159687; D 159687;1-(4-((3'-chloro-6-methoxybiphenyl-3-yl)methyl)phenyl)urea;Inhibitor,inhibit,D159687,D-159687,Phosphodiesterase (PDE);[4-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]phenyl]urea;4-({3'-chloro-6-methoxy-[1,1'-biphenyl]-3-yl}methyl)phenyl]urea;1-(4-((3'-Chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea;Urea, N-[4-[(3'-chloro-6-methoxy[1,1'-biphenyl]-3-yl)methyl]phenyl]-
- CBNumber:
- CB82642455
- Molecular Formula:
- C21H19ClN2O2
- Molecular Weight:
- 366.84
- MDL Number:
- MFCD26793458
- MOL File:
- 1155877-97-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| D159687 ≥98% (HPLC) | SML3379 | 5MG | $80.5 |
| D159687 ≥98% (HPLC) | SML3379 | 25MG | $323 |
| D159687 ≥98% | 38778 | 5mg | $65 |
| D159687 ≥98% | 38778 | 10mg | $104 |
| D159687 ≥98% | 38778 | 25mg | $228 |
| Boiling point | 502.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.263±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO : 150 mg/mL (408.90 mM) |
| pka | 14.48±0.50(Predicted) |
| form | Solid |
| color | White to off-white |
| InChI | 1S/C21H19ClN2O2/c1-26-20-10-7-15(12-19(20)16-3-2-4-17(22)13-16)11-14-5-8-18(9-6-14)24-21(23)25/h2-10,12-13H,11H2,1H3,(H3,23,24,25) |
| InChIKey | RJJLUTWHJUDZFP-UHFFFAOYSA-N |
| SMILES | Clc1cc(ccc1)c2c(ccc(c2)Cc3ccc(cc3)NC(=O)N)OC |
| FDA UNII | 4T436CO8BT |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3379 | D159687 ≥98% (HPLC) | 1155877-97-6 | 5MG | $80.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3379 | D159687 ≥98% (HPLC) | 1155877-97-6 | 25MG | $323 | 2026-04-30 | Buy |
| Cayman Chemical | 38778 | D159687 ≥98% | 1155877-97-6 | 5mg | $65 | 2026-04-30 | Buy |
| Cayman Chemical | 38778 | D159687 ≥98% | 1155877-97-6 | 10mg | $104 | 2026-04-30 | Buy |
| Cayman Chemical | 38778 | D159687 ≥98% | 1155877-97-6 | 25mg | $228 | 2026-04-30 | Buy |
1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea Chemical Properties,Uses,Production
Uses
D-159687 is a selective inhibitor of cyclic AMP phosphodiesterase 4D (PDE4D).
Biological Activity
D159687 is a brain-penetrant, orally available, highly potent and selective negative allosteric modulator (NAM) against phosphodiesterase 4 (PDE4) subtype PDE4D (hPDE4D7 IC50 = 27 nM; PDE4A1/B1/C1 IC50 = 2.50/1.47/6.80 μM; IC50 ≥29 μM against PDE1/2/3/5/7/8/9/10/11 subtypes). Comparing to Rolipram, D159678 offers similar in vivo efficacy on long-term memory formation by novel object recognition test (MED = 3 μg/kg mouse iv., 1 μg/kg r at p.o.), while being more effective in the scopolamine-impaired Y-maze tests (D159678/Rolipram MED = 0.1/1 μg/kg mouse iv. or 30/100 μg/kg mouse p.o.) and much less emetic in shrews/dog/monkeys (by 100-/3000-/500-fold).
in vivo
D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques[2].
| Animal Model: | Female Cynomolgus macaques (4–6 year old) [2] |
| Dosage: | 0.05, 0.5, 5 mg/kg |
| Administration: | Oral daily for a week |
| Result: | A potential recruitment or enhancement of synaptic function with increased task difficulty. |
IC 50
PDE4
1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea Preparation Products And Raw materials
Raw materials
Preparation Products
1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32998 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6290 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11674 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9935 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
