(4-chloro-2-fluoro-phenyl)-carbaMic acid tert-butyl ester
- CAS No.
- 956828-47-0
- Chemical Name:
- (4-chloro-2-fluoro-phenyl)-carbaMic acid tert-butyl ester
- Synonyms
- tert-Butyl (4-chloro-2-fluorophenyl)carbaMate;1,1-Dimethylethyl N-(4-chloro-2-fluorophenyl)carbamate;(4-chloro-2-fluoro-phenyl)-carbaMic acid tert-butyl ester;Carbamic acid, N-(4-chloro-2-fluorophenyl)-, 1,1-dimethylethyl ester
- CBNumber:
- CB82644262
- Molecular Formula:
- C11H13ClFNO2
- Molecular Weight:
- 245.68
- MDL Number:
- MFCD21170448
- MOL File:
- 956828-47-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
(4-chloro-2-fluoro-phenyl)-carbaMic acid tert-butyl ester price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | GNB82847 | tert-Butyl (4-chloro-2-fluorophenyl)carbamate | 956828-47-0 | 10g | $354 | 2026-06-04 | Buy |
| aablocks | AA00IJ9P | tert-Butyl (4-chloro-2-fluorophenyl)carbamate 95% | 956828-47-0 | 1g | $63 | 2026-05-29 | Buy |
| aablocks | AA00IJ9P | tert-Butyl (4-chloro-2-fluorophenyl)carbamate 95% | 956828-47-0 | 5g | $157 | 2026-05-29 | Buy |
| aablocks | AA00IJ9P | tert-Butyl (4-chloro-2-fluorophenyl)carbamate 95% | 956828-47-0 | 10g | $257 | 2026-05-29 | Buy |
| aablocks | AA00IJ9P | tert-Butyl (4-chloro-2-fluorophenyl)carbamate 97% | 956828-47-0 | 25g | $611 | 2026-05-29 | Buy |
(4-chloro-2-fluoro-phenyl)-carbaMic acid tert-butyl ester Chemical Properties, Uses, Production
Synthesis
24424-99-5
956828-47-0
The general procedure for the synthesis of tert-butyl (4-chloro-2-fluorophenyl)-carbamate from di-tert-butyl dicarbonate is as follows: Example 1: N-(4-chloro-2-fluorophenyl)-N-methyl-3-oxo-1H,3H-spiro[2-benzofuran-1,3'-pyrrolidine]-1'-carboxamide Step 1. Synthesis of tert-butyl tert-butyl (4-chloro-2-fluorophenyl)carbamate To a solution of 4-chloro-2-fluoroaniline (4.0 mL, 0.036 mol; Aldrich) in tetrahydrofuran (40 mL, 0.4 mol) was added slowly and dropwise 1.0 M lithium hexamethyldisilazide in tetrahydrofuran (72 mL) at 0 °C for 1 hour. After the reaction solution turned bright purple, it was warmed to room temperature and stirring was continued for 30 min. Subsequently, a tetrahydrofuran solution (20 mL, 0.2 mol) of di-tert-butyl dicarbonate (8.30 g, 0.0380 mol) was added dropwise over 10 minutes. The reaction mixture was stirred at room temperature for 35 min before the reaction was quenched with saturated ammonium chloride solution and diluted with ethyl acetate to separate the organic layer. The combined organic layers were dried with anhydrous sodium sulfate and concentrated to dryness under reduced pressure. The residue was purified by combiflash fast column chromatography using a gradient elution with a hexane solution of 0-10% ethyl acetate to give 4.33 g of orange solid product in 48.9% yield.The LCMS assay showed [M + H]+ of 246.1.
References
[1] Patent: WO2007/130898, 2007, A1. Location in patent: Page/Page column 48
(4-chloro-2-fluoro-phenyl)-carbaMic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 | sales@fartop.net | China | 2227 | 55 |
| Nanjing Chalf-Pharm Technology Co., Ltd. | 025-57018978 18251899859 | sales@chalf-pharm.com | China | 5855 | 50 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| Nanjing River Chemical Co., Ltd. | 13951936332 18305166317 | info@serpharm.com | China | 493 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15078 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Henan Weitesi Chemical Technology Co. LTD | 0371-55135753 18003832934 | 3842570495@qq.com | China | 9989 | 58 |
| Shanghai Sunway Pharmaceutical Technology Co.,Ltd. | 13611835272 13611835272 | mmwang@sunwaypharm.com | China | 44090 | 58 |
| Bide Pharmatech Ltd. | 400-6005915 | sales@picasso-e.com | China | 39662 | 58 |
