LY2334737
- CAS No.
- 892128-60-8
- Chemical Name:
- LY2334737
- Synonyms
- LY2334737;LY2334737, 10 mM in DMSO;LY 2334737;LY-2334737;LY2334737;2'-Deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)cytidine;Cytidine, 2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)-;N-{1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl}-2-propylpentanamide;N-(1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-propylpentanamide;anticancer,HEV,Gemcitabine,HEVs,HRVs,LY 2334737,EV-A71,Rhinovirus,inhibit,Nucleoside Antimetabolite/Analog,Enterovirus,HRV,orally,LY2334737,LY-2334737,antiviral,Inhibitor
- CBNumber:
- CB82668271
- Molecular Formula:
- C17H25F2N3O5
- Molecular Weight:
- 389.39
- MDL Number:
- MFCD25976631
- MOL File:
- 892128-60-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.41±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 9.66±0.20(Predicted) |
| color | White to off-white |
| FDA UNII | YLR364XYSA |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
LY2334737 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 37425 | LY2334737 ≥95% | 892128-60-8 | 1mg | $28 | 2026-04-30 | Buy |
| Cayman Chemical | 37425 | LY2334737 ≥95% | 892128-60-8 | 5mg | $131 | 2026-04-30 | Buy |
| Cayman Chemical | 37425 | LY2334737 ≥95% | 892128-60-8 | 10mg | $248 | 2026-04-30 | Buy |
| Cayman Chemical | 37425 | LY2334737 ≥95% | 892128-60-8 | 25mg | $550 | 2026-04-30 | Buy |
| ChemScene | CS-1815 | LY2334737 98.55% | 892128-60-8 | 5mg | $168 | 2026-06-04 | Buy |
LY2334737 Chemical Properties, Uses, Production
Uses
LY2334737 is an nucleoside analog and is an orally active proagent of Gemcitabine. LY2334737 exhibits inhibitory activity against enterovirus A71 (EV-A71) infection. LY2334737 has antiviral and anticancer effects[1][2].
Biological Activity
ly2334737 is an oral prodrug of gemcitabine, the clinically efficacious anticancer agent [1].ly2334737 has been shown the hydrolytic activity by carboxylesterase 2 (ces2). the michaelis-menten kinetic parameters are exhibited to be : km of 43μm and vmax of 40nmol/min/mg protein. in addition, ly2334737 has been found to be cytotoxic to cells in the ncl-60 panel with the ec50 values of 0.512±0.016μm, 0.402±0.018μm and 0.034±0.002μm for pc-gfp alone, hct-116 mock transfectant and hct-116 ces2 transfectant cell lines, respectively. apart from these, the study result has been noted that parental sk-ov-3 cells were approximately 4-fold more sensitive to ly2334737 cytotoxicity than the sk-ov-3 knockdown with the ec50 values of 1.1μm and 4.5μm, respectively [1].
in vivo
Oral treatment of xenograft models with 3.2 mg/kg LY2334737 once a day for 21 days shows greater tumor growth inhibition of CES2 transfectant than the mock transfectant[1].
Metronomic LY2334737 administration causes increased blood flow in luciferase-tagged LM2-4 tumor xenografts, and this effect, readily measured using contrast micro-ultrasound, coincided with a relative increase in tumor bioluminescence[3].
References
[1] pratt se1, durland-busbice s, shepard rl, heinz-taheny k, iversen pw, dantzig ah. human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (ly2334737) and confers prodrug sensitivity to cancer cells. clin cancer res. 2013 mar 1;19(5):1159-68.
LY2334737 Preparation Products And Raw materials
Raw materials
Preparation Products
LY2334737 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Lianyungang TengFa Biological Technology Co. Ltd | 0518-85475186 18705131893 | wang666xt@163.com | China | 351 | 55 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3853 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
