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LY 294002 Hydrochloride

LY 294002 Hydrochloride structure

CAS No.: 154447-36-6

Chemical Name:: LY 294002 Hydrochloride

Synonyms: YX;CS-1859;SF 1101;LY240092;LY 294002;NSC 697286;LY294002HCl;LY294002/PI3K;LY 294002, 99+%;LY294002 ，S1105

CBNumber:: CB1242450

Molecular Formula:: C19H17NO3

Molecular Weight:: 307.34

MDL Number:: MFCD01530034

MOL File:: 154447-36-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-08-30 11:39:11

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LY 294002 Hydrochloride Properties

Melting point	183-185℃
Boiling point	494.6±45.0 °C(Predicted)
Density	1.266
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: >5 mg/mL
form	solid
pka	0.55±0.20(Predicted)
color	white to off-white
Water Solubility	Soluble in DMSO at 5mg/ml. Insoluble in water
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
InChI	InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChIKey	CZQHHVNHHHRRDU-UHFFFAOYSA-N
SMILES	C1(N2CCOCC2)OC2=C(C3=CC=CC=C3)C=CC=C2C(=O)C=1
CAS DataBase Reference	154447-36-6
FDA UNII	31M2U1DVID
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H302-H320-H361-H370-H372-H336-H402
Precautionary statements	P501-P273-P260-P270-P202-P201-P271-P264-P280-P337+P313-P305+P351+P338-P308+P311-P301+P312+P330-P304+P340+P312-P403+P233-P405
Safety Statements	24-25
WGK Germany	3
HS Code	29349990
Storage Class	10 - Combustible liquids

LY 294002 Hydrochloride price More Price(117)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	440202	LY 294002	154447-36-6	5mg	$238	2026-04-30	Buy
Sigma-Aldrich	440202	LY 294002	154447-36-6	10mg	$351	2026-04-30	Buy
Sigma-Aldrich	19-142	LY 294002		1mg	$200	2026-04-30	Buy
TCI Chemical	M2410	2-Morpholino-8-phenylchromone >98.0%(HPLC)	154447-36-6	25mg	$175	2026-04-30	Buy
Cayman Chemical	70920	LY294002 ≥98%	154447-36-6	5mg	$31	2026-04-30	Buy

Product number	Packaging	Price	Buy
440202	5mg	$238	Buy
440202	10mg	$351	Buy
19-142	1mg	$200	Buy
M2410	25mg	$175	Buy
70920	5mg	$31	Buy

LY 294002 Hydrochloride Chemical Properties,Uses,Production

Description

LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC₅₀ of 1.4 μM.

Uses

LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590).

Uses

A potent blocker of PI 3-kinase/Akt signaling.

Uses

LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice.

Definition

ChEBI: LY294002 is a chromone substituted with a phenyl group at position 8 and a morpholine group at position 2. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor, an autophagy inhibitor and a geroprotector. It is a member of chromones, a member of morpholines and an organochlorine compound.

Biological Activity

A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 values are 0.31, 0.73, 1.06 and 6.60 μ M for PI3K β , PI3K α , PI3K δ and PI3K γ respectively). Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo .

target

p110α

Background

LY294002 was shown to act in vivo as a highly selective inhibitor of phosphatidylinositol 3 kinase. When used at a concentration of 50 μM, it specifically abolished PI3 kinase activity but did not inhibit other lipid and protein kinases such as PI4 kinase, PKC, MAP kinase or c-Src. LY294002 is soluble in DMSO or ethanol. For use with in vitro or cell-based assays, it may be diluted into aqueous buffers to yield the desired concentrations.

References

[1] C. VLAHOS. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).[J]. The Journal of Biological Chemistry, 1994, 93 1: 5241-5248. DOI:10.1016/s0021-9258(17)37680-9.
[2] SEVERINE I GHARBI. Exploring the specificity of the PI3K family inhibitor LY294002.[J]. ACS Applied Energy Materials, 2007: 15-21. DOI:10.1042/BJ20061489.
[3] SANCHEZMARGALET V. Role of Phosphatidylinositol-3-Kinase in Insulin Receptor Signaling: Studies with Inhibitor, LY294002[J]. Biochemical and biophysical research communications, 1994, 204 2: Pages 446-452. DOI:10.1006/bbrc.1994.2480.

LY 294002 Hydrochloride Preparation Products And Raw materials

Raw materials

4H-1-Benzopyran-4-one, 8-hydroxy-2-(4-morpholinyl)- 1-(2-hydroxybiphenyl-3-yl)-3-morpholinopropane-1,3-dione N-Acetylmorpholine Trifluoro-methanesulfonic acid 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl ester methyl 2-hydroxy-3-phenyl-benzoate

methyl 2,3-dihydroxybenzoate Methyl 3-methoxysalicylate 2,3-Dihydroxybenzoic acid 3-Methoxysalicylic acid Phenylboronic acid

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Preparation Products

LY 294002 Hydrochloride Suppliers

Global( 407)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zhengzhou HSH Science & Technology Co., Ltd.	0371-55932928 18937192232;	1282296214@qq.com	China	497	55
TargetMol Chemicals Inc.	021-021-33632979 15002134094	marketing@targetmol.com	China	7993	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Ascent Scientific	4401179829988	customerservice@ascentscientific.co.uk	United Kingdom	279	60
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60

Supplier	Advantage
Zhengzhou HSH Science & Technology Co., Ltd.	55
TargetMol Chemicals Inc.	58
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chembest Research Laboratories Limited	61
TCI (Shanghai) Development Co., Ltd.	81
Capot Chemical Co., Ltd	66
Ascent Scientific	60
JinYan Chemicals(ShangHai) Co.,Ltd.	60

View Lastest Price from LY 294002 Hydrochloride manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-08-30	LY294002 154447-36-6	$34.00-68.00		99.89%	10g	TargetMol Chemicals Inc.
	2019-07-06	LY 294002 HYDROCHLORIDE 154447-36-6	$2.00	1kg	99%	100kg	Career Henan Chemical Co

LY294002
154447-36-6
$34.00-68.00
99.89%
TargetMol Chemicals Inc.

LY 294002 HYDROCHLORIDE
154447-36-6
$2.00
99%
Career Henan Chemical Co

LY 294002 Hydrochloride Spectrum

LY 294002 HYDROCHLORIDE(154447-36-6)¹HNMR

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LY 294002 LY 294002 HYDROCHLORIDE 2-[4-MORPHOLINYL]-8-PHENYL-1[4H]-BENZOPYRAN-4-ONE 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE HYDROCHLORIDE 2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE CS-1859 LY294002 (HCl Salt) 2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ON InSolution LY 294002 - CAS 154447-36-6 - Calbiochem LY 294002 - CAS 154447-36-6 - Calbiochem LY 294002, 99+% LY294002HCl 2-(4-morpholinyl)-8-phenyl-1(4h)-benzopyran-4-one hydrochloride LY-294002;LY 294002;LY 294002 HYDROCHLORIDE;2-[4-MORPHOLINYL]-8-PHENYL-1[4H]-BENZOPYRAN-4-ONE;2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE;2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE HYDROCHLORIDE;2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE 8-Phenyl-2-(morpholin-4-yl)chromen-4-one 2-[4-Morpholinyl]-8-phenyl-1[4H]-benzopyran-4-on NSC 697286 SF 1101 2-Morpholino-8-phenyl-4H-chroMen-4-one 2-Morpholino-8-phenylchroMone 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one LY 294002 LY 294002 8-Phenyl-2-(morpholin-4-yl)chromen-4-one LY294002 (HCI Salt) LY240092 LY294002, NSC 697286 2-Morpholino-8-phenyl-4-oxo-4H-1-benzopyran InSolution? LY 294002 2-(4-Morpholinyl)-8-phenyl-4H-chromen-4-on NSC 697286; SF 1101; LY 294002; LY-294002 Morpholino phenylchromone 2-Morpholino-8-phenylchromone> 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl- YX LY294002/PI3K LY 294002 HYDROCHLORIDE USP/EP/BP LY 294002, Free Base LY 294002 (DMSO solution) LY 294002 (DMSO solution), PI3-kinase inhibitor LY294002, 10 mM in DMSO PI3K inhibitor kit LY294002 ，S1105 2-morpholine-8-phenylone 154447-36-6 C19H18ClNO3HCl C19H17O3N Specific cell permeable phosphatidylinositol 3-kinase inhibitor. Cell Biology Cell Signaling and Neuroscience BioChemical Kinase/Phosphatase Biology Phosphatidylinositol 3-kinase (PI3K) Serine/Threonine Kinase Inhibitors PI3K/Akt Signaling Inhibitors Inhibitor Anti-cancer&immunity PI3K/Akt/mTOR