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1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone

1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone Structure
1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone structure
CAS No.
228572-69-8
Chemical Name:
1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone
Synonyms
2’-Hydroxy-4’-(trifluoromethyl)acetophenone;2'-Hydroxy-4'-(trifluoromethyl)acetophenone;1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone;Ethanone, 1-[2-hydroxy-4-(trifluoromethyl)phenyl]-;1-[2-Hydroxy-4-(trifluoromethyl)phenyl]ethan-1-one;1-[2-hydroxy-4-(trifluoromethyl)phenyl]ethanone - [H85387]
CBNumber:
CB82671644
Molecular Formula:
C9H7F3O2
Molecular Weight:
204.15
MDL Number:
MFCD09754177
MOL File:
228572-69-8.mol
MSDS File:
SDS
Last updated:2026-05-28 05:53:13
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1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone Properties

storage temp. 2-8°C
Appearance Colorless to light yellow Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth DJA57269 1-(2-Hydroxy-4-trifluoromethyl-phenyl)-ethanone 228572-69-8 2.5g $383.5 2026-06-04 Buy
Activate Scientific AS120827 1-(2-Hydroxy-4-(trifluoromethyl)phenyl)-ethanone 97% 228572-69-8 1g $112 2026-06-04 Buy
Activate Scientific AS120827 1-(2-Hydroxy-4-(trifluoromethyl)phenyl)-ethanone 97% 228572-69-8 5g $475 2026-06-04 Buy
Matrix Scientific 309305 1-(2-Hydroxy-4-(trifluoromethyl)phenyl)ethanone 228572-69-8 250.00mg $56 2026-05-19 Buy
Matrix Scientific 309305 1-(2-Hydroxy-4-(trifluoromethyl)phenyl)ethanone 228572-69-8 1.00g $110 2026-05-19 Buy
Product number Packaging Price Buy
DJA57269 2.5g $383.5 Buy
AS120827 1g $112 Buy
AS120827 5g $475 Buy
309305 250.00mg $56 Buy
309305 1.00g $110 Buy

1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone Chemical Properties, Uses, Production

Synthesis

1-Ethoxy-3-trifluoromethyl-1,3-butadiene

59938-06-6

Acetylacetone

123-54-6

1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone

228572-69-8

General procedure for the synthesis of 1-(2-hydroxy-4-(trifluoromethyl)phenyl)ethanone from (E)-1-ethoxy-3-trifluoromethyl-1,3-butadiene and acetylacetone: at 0 °C, 4-ethoxy-1,1,1-trifluoro-3-buten-2-one (5 g, 29.7 mmol) and 2,4-pentanedione (3.05 mL, 29.7 mmol) were were added sequentially to a suspension of THF (120 mL) containing NaH (2.38 g, 59.4 mmol). The reaction mixture was refluxed for 4 h and subsequently partitioned with 1N HCl and EtOAc. The organic layer was washed with brine, dried over Na2SO4 and concentrated to give a red oil. Purification by fast column chromatography (eluent: hexane solution with 0 to 10% EtOAc) afforded 1-(2-hydroxy-4-(trifluoromethyl)phenyl)ethanone as a yellow oil (1.73 g, 29% yield).1H NMR (400 MHz, CDCl3): δ 2.69 (s, 3H), 7.15 (d, J = 9.9 Hz, 1H). 7.25 (s, 1H), 7.86 (d, J = 8.3 Hz, 1H), 12.29 (s, 1H).

References

[1] Patent: WO2004/74270, 2004, A2. Location in patent: Page 192
[2] Dalton Transactions, 2014, vol. 43, # 10, p. 4127 - 4136

1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone Preparation Products And Raw materials

Raw materials

1-Ethoxy-3-trifluoromethyl-1,3-butadiene Acetylacetone Sodium hydride Tetrahydrofuran

Preparation Products

1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone Suppliers

Global Suppliers ( 39)
Supplier Tel Email Country ProdList Advantage
SuZhou ShiYa Biopharmaceuticals, Inc. 86(512)5235 8471 17715136450 sales@shiyabiopharm.com China 4167 58
Shanghai AQBioPharma Co., Ltd. 13661411401 yinglv.que@aqbiopharma.com.cn China 2976 58
Hangzhou Milestone Pharmtech Co., Ltd. 0571-82896630 18969958410 sales_hz@milestonepharmtech.com China 4908 55
JW & Y Pharmlab Co., Ltd. 021-64340559 xinyu_shi@jwypharmlab.com.cn China 11999 58
BePharm Ltd 400-685-9117 market@bepharm.com China 15081 60
Nanjing Nohon Biological Technology Co., Ltd. 025-85767923 18512596075; sales@nuoxibio.com China 975 55
Capot Chemical Co.,Ltd. +86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Aikon International Limited 025-58859352 15955137747 sales01@aikonchem.com China 16021 58
Suzhou Xiya Pharmaceutical Co., Ltd. 0512-87819718 18912655635 2587879032@qq.com China 1276 58
Hefei Molake Biotechnology Co., Ltd. 0551-66336380 18956014586 983438788@qq.com China 2469 58
Supplier Advantage
SuZhou ShiYa Biopharmaceuticals, Inc. 58
Shanghai AQBioPharma Co., Ltd. 58
Hangzhou Milestone Pharmtech Co., Ltd. 55
JW & Y Pharmlab Co., Ltd. 58
BePharm Ltd 60
Nanjing Nohon Biological Technology Co., Ltd. 55
Capot Chemical Co.,Ltd. 60
Aikon International Limited 58
Suzhou Xiya Pharmaceutical Co., Ltd. 58
Hefei Molake Biotechnology Co., Ltd. 58

1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone Spectrum

1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone(228572-69-8)1HNMR1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone(228572-69-8)19FNMR

228572-69-8 (1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone) Related Search:

2-Formyl-5-(trifluoromethyl)phenol, 4-Formyl-3-hydroxybenzotrifluoride, 4-(Trifluoromethyl)salicylaldehyde 2'-hydroxy-5'-(trifluoroMethyl)acetophenone 2-(1-Hydroxyethyl)-5-(trifluoromethyl)phenol 1-[2-hydroxy-4-(trifluoromethyl)phenyl]propan-1-one 1-[2-Hydroxy-6-methyl-4-(trifluoromethyl)phenyl]ethanone
Ethanone, 1-[3-hydroxy-4-(trifluoromethyl)phenyl]-

1of2

1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone 2'-Hydroxy-4'-(trifluoromethyl)acetophenone 1-[2-Hydroxy-4-(trifluoromethyl)phenyl]ethan-1-one Ethanone, 1-[2-hydroxy-4-(trifluoromethyl)phenyl]- 2’-Hydroxy-4’-(trifluoromethyl)acetophenone 1-[2-hydroxy-4-(trifluoromethyl)phenyl]ethanone - [H85387] 228572-69-8