Diphenylphosphinic Chloride
- CAS No.
- 1499-21-4
- Chemical Name:
- Diphenylphosphinic Chloride
- Synonyms
- DPPC;DPP-CL;DIPHENYLPHOSPHINIC CHLORIDE;Ph2POCl;DIPHENYLPHOSPHINYL CHLORIDE;Diphenylphosphinoyl chloride;CHLORODIPHENYLPHOSPHINE OXIDE;Diphenylphosphinic acid chloride;phosphinic chL;Diphenylphoshinic
- CBNumber:
- CB8273899
- Molecular Formula:
- C12H10ClOP
- Molecular Weight:
- 236.63
- MDL Number:
- MFCD00002077
- MOL File:
- 1499-21-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 20°C |
|---|---|
| Boiling point | 222 °C/16 mmHg (lit.) |
| Density | 1.24 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 79 °F |
| storage temp. | 2-8°C |
| solubility | soluble in Chloroform, methanol |
| form | Liquid |
| color | Clear colorless to yellow |
| Specific Gravity | 1.24 |
| Water Solubility | decomposes |
| Sensitive | Moisture Sensitive |
| BRN | 975191 |
| InChI | 1S/C12H10ClOP/c13-15(14,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H |
| InChIKey | QPQGTZMAQRXCJW-UHFFFAOYSA-N |
| SMILES | ClP(=O)(c1ccccc1)c2ccccc2 |
| CAS DataBase Reference | 1499-21-4(CAS DataBase Reference) |
| FDA UNII | 5GP30GY04V |
| NIST Chemistry Reference | Diphenylphosphinic chloride(1499-21-4) |
| UNSPSC Code | 12352002 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H314 | |||||||||
| Precautionary statements | P210-P280-P303+P361+P353-P305+P351+P338+P310 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C,F | |||||||||
| Risk Statements | 10-34 | |||||||||
| Safety Statements | 16-26-36/37/39-45 | |||||||||
| RIDADR | UN 2920 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| Hazard Note | Flammable/Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29310095 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Eye Dam. 1 Flam. Liq. 3 Skin Corr. 1B Skin Sens. 1A |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Diphenylphosphinic Chloride price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 230235 | Diphenylphosphinic chloride 98% | 1499-21-4 | 10g | $82.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | 230235 | Diphenylphosphinic chloride 98% | 1499-21-4 | 50g | $325 | 2026-04-30 | Buy |
| TCI Chemical | C1415 | Diphenylphosphinic Chloride >98.0%(GC)(T) | 1499-21-4 | 25g | $121 | 2026-04-30 | Buy |
| Strem Chemicals | 15-1740 | Diphenylphosphinic chloride, 98% 98% | 1499-21-4 | 5g | $41 | 2026-04-30 | Buy |
| Strem Chemicals | 15-1740 | Diphenylphosphinic chloride, 98% 98% | 1499-21-4 | 25g | $147 | 2026-04-30 | Buy |
Diphenylphosphinic Chloride Chemical Properties, Uses, Production
Chemical Properties
clear colorless to yellow liquid
Uses
Diphenylphosphinic chloride (Ph2POCl) is widely used as a precursor to synthesize various chiral phosphine bidentate ligands for asymmetric synthesis, in addition to several peptide coupling agents.
Application
Diphenylphosphinic chloride is a reagent that is used in the synthesis of bidentate ligands and peptide coupling agents. It is used as flame retardants. It also act as pharmaceutical adjuvant.
reaction suitability
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
Synthesis
To an oven-dried 100 mL, a two-necked flask fitted with a reflux condenser was added Et2O (depending on the Grignard reagent solution's concentration) and POCl3. The solution was cooled in an ice-salt mixture, and a Grignard reagent solution in Et2O was slowly added. After stirring with cooling for 30 min, the reaction mixture was brought to rt and stirred for the indicated time. The mixture was then cooled in an ice-salt mixture, and the alcohol and pyridine were slowly added. Stirring with cooling for 5 min was followed by reaction at rt. The reaction was quenched after the indicated time by cooling in an ice-salt mixture and adding sat aq NH4Cl. The crude mixture was then poured into CH2Cl2, washed three times with HCl, dried, filtered, and evaporated to dryness. The excess alcohol was removed using a short-path vacuum distillation apparatus, and the resulting crude product Diphenylphosphinic Chloride was purified by column chromatography.
Diphenylphosphinic Chloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| xinxiang runyu material co.,Ltd | 03737759608 15690792173 | sales@runvmat.com | China | 300 | 58 |
| Hubei Jusheng Technology Co.,Ltd | 027-59599241 18871490274 | 1400878000@qq.com | China | 9506 | 58 |
| Shaoxing Fangxiao Chemical Co., LTD | +86-13456999252; 13456999252 | shellyhouse39@126.com | China | 41 | 58 |
| Jiangsu Huaweisite Pharmaceutical Technology Co., Ltd. | 0519-88721112 | supporting@harvechem.com | China | 84 | 58 |
| BEIJING ODYSSEY CHEMICALS CO.,LTD | 10-88018188-315 17502279376 | kallisto@bj-odyssey.com | China | 32 | 58 |
| Shijiazhuang Benchu Technology Co., Ltd. | 0311-680150596798-6798 17367983103 | 925646462@qq.com | China | 29 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Beijing Donghualituo Techonlogy Development Co.,Ltd. | 010-88425576 | sales@dhltchem.com | China | 793 | 59 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
View Latest Price from Diphenylphosphinic Chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | Diphenylphosphinic chloride, 98%
1499-21-4
|
$20.00 | 1KG | 98% | 200tons/ year | Speranza Chemical Co., Ltd.
|
|
 |
2026-06-30 | Diphenylphosphinic Chloride
1499-21-4
|
1KG | 99.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-12-23 | Diphenylphosphinic Chloride
1499-21-4
|
1KG | 99%+ | 250KG | XINXIANG RUNYU MATERIAL CO., LTD. |
-
- Diphenylphosphinic chloride, 98%
1499-21-4
- $20.00
- 98%
- Speranza Chemical Co., Ltd.
-
- Diphenylphosphinic Chloride
1499-21-4
- 99.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- Diphenylphosphinic Chloride
1499-21-4
- 99%+
- XINXIANG RUNYU MATERIAL CO., LTD.
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