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(E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine

(E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine structure

CAS No.: 1232221-74-7

Chemical Name:: (E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine

Synonyms: APY0201;APY0201, >98%;APY0201, 10 mM in DMSO;APY 0201 ;APY-0201 ;APY0201;Inhibitor,APY0201,Interleukin Related,APY-0201,APY 0201,PIKfyve,Fab1,inhibit;N-(3-methylbenzylidene)-N'-(7-morpholin-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine; 4-(5-(2-(3-Methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine;Benzaldehyde, 3-methyl-, 2-[7-(4-morpholinyl)-2-(4-pyridinyl)pyrazolo[1,5-a]pyrimidin-5-yl]hydrazone;(E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine;N-(3-Methylbenzylidene)-N'-[7-(morpholin-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl]hydrazine

CBNumber:: CB82742489

Molecular Formula:: C23H23N7O

Molecular Weight:: 413.48

MDL Number:: MFCD28386328

MOL File:: 1232221-74-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

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(E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine Properties

Density	1.33±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:20.0(Max Conc. mg/mL);48.37(Max Conc. mM) DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.8(Max Conc. mM) DMF:3.0(Max Conc. mg/mL);7.26(Max Conc. mM)
form	A crystalline solid
pka	17.36±0.70(Predicted)
color	Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

(E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	9001589	APY0201 ≥98%	1232221-74-7	1mg	$41	2026-04-30	Buy
Cayman Chemical	9001589	APY0201 ≥98%	1232221-74-7	5mg	$157	2026-04-30	Buy
Cayman Chemical	9001589	APY0201 ≥98%	1232221-74-7	10mg	$293	2026-04-30	Buy
Cayman Chemical	9001589	APY0201 ≥98%	1232221-74-7	25mg	$631	2026-04-30	Buy
ChemScene	CS-4162	APY0201 99.42%	1232221-74-7	1mg	$67	2026-06-04	Buy

Product number	Packaging	Price	Buy
9001589	1mg	$41	Buy
9001589	5mg	$157	Buy
9001589	10mg	$293	Buy
9001589	25mg	$631	Buy
CS-4162	1mg	$67	Buy

(E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine Chemical Properties, Uses, Production

Uses

APY0201 is a potent PIKfyve inhibitor, which inhibits the conversion of PtdIns3P to PtdIns(3,5)P2 in the presence of in the presence of [33P]ATP with an IC50 of 5.2 nM. APY0201 also inhibits IL-12/IL-23 production.

in vivo

Oral APY0201 at a 30 mg/kg dose shows significant reduction of IL-12p70 production (78% inhibition relative to that of the vehicle control), which implys that the inhibitory potential of APY0201 against IL-12 is confirmed in the animal experiment^[1].

IC 50

PIKfyve: 5.2 nM (IC₅₀); IL-12; IL-23

References

[1] Hayakawa N, et al. Structure-activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201. Bioorg Med Chem. 2014 Jun 1;22(11):3021-9. DOI:10.1016/j.bmc.2014.03.036

(E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine Preparation Products And Raw materials

Raw materials

Preparation Products

(E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine Suppliers

Global Suppliers ( 79)

Supplier	Tel	Email	Country	ProdList	Advantage
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4853	58
Shanghai JiYi Biotechnology Co. Ltd.	13621943973	sales@shjiyipharmatech.com	China	1166	55
Cool Pharm, Ltd	021-60455363 18019463053	sales@coolpharm.com	China	8455	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4859	55
D&C Chemicals	+86-21-58447131	1724405207@qq.com	China	470	55
ShangHai Siyan Biological Technology Co., Ltd.	021-50908862，442785678，326799392 18721037013	siyansales@126.com	China	9612	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Guangzhou QiYun Biotechnology Co., Ltd.	020-61288194 61288195	505721671@qq.com	China	3853	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60

Supplier	Advantage
Haoyuan Chemexpress Co., Ltd.	61
MedChemexpress LLC	58
Shanghai JiYi Biotechnology Co. Ltd.	55
Cool Pharm, Ltd	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
D&C Chemicals	55
ShangHai Siyan Biological Technology Co., Ltd.	58
Shanghai EFE Biological Technology Co., Ltd.	58
Guangzhou QiYun Biotechnology Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60

View Latest Price from (E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	APY0201 1232221-74-7	$109.00-347.00		99.74%	10g	TargetMol Chemicals Inc.

APY0201
1232221-74-7
$109.00-347.00
99.74%
TargetMol Chemicals Inc.

(E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine Spectrum

(E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine(1232221-74-7)¹HNMR

1232221-74-7 ((E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine) Related Search:

PIKfyve-IN-2 (E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine (S)-N-(2-(1-(3-ethoxy-4-hydroxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide APILIMOD UCB9608

Deucravacitinib

1of2

(E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine APY0201 N-(3-Methylbenzylidene)-N'-[7-(morpholin-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl]hydrazine N-(3-methylbenzylidene)-N'-(7-morpholin-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine APY 0201 ;APY-0201 ;APY0201 APY0201, >98% 4-{5-[(E)-2-[(3-methylphenyl)methylidene]hydrazin-1-yl]-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl}morpholine Benzaldehyde, 3-methyl-, 2-[7-(4-morpholinyl)-2-(4-pyridinyl)pyrazolo[1,5-a]pyrimidin-5-yl]hydrazone Inhibitor,APY0201,Interleukin Related,APY-0201,APY 0201,PIKfyve,Fab1,inhibit 4-(5-(2-(3-Methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine APY0201, 10 mM in DMSO (e)-4-(5-(2-(3-methylbenzylidene)hydrazineyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine 1232221-74-7 C23H23N7O Inhibitors