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ChemicalBook >> CAS DataBase List >>cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate Structure
cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate structure
CAS No.
67914-86-7
Chemical Name:
cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate
Synonyms
CIS-DTM;Cis-trimesylate;Itraconazole Impurity 8;Itraconazole Impurity 14;CHLOROPHYLLIN (IN PASTE );Cis-[2-(2,4-Dichlorophenyl)-2-;Itraconazole Sulfonate IMpurity;Itraconazole Dioxolonyl IMpurity;cis-2-(2,4-Dichlorophenyl)-2-(1H-1,;ITRACOZOLE HYDROXY ISOBUTYLTRIAZOLONE IMPURITY
CBNumber:
CB8282981
Molecular Formula:
C14H15Cl2N3O5S
Molecular Weight:
408.26
MDL Number:
MFCD06410887
MOL File:
67914-86-7.mol
MSDS File:
SDS
Last updated:2026-05-28 03:32:06
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cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate Properties

Melting point 98 °C
Boiling point 615.5±65.0 °C(Predicted)
Density 1.59±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form Solid
pka 2.94±0.12(Predicted)
color White to Off-White
InChI InChI=1/C14H15Cl2N3O5S/c1-25(20,21)23-6-11-5-22-14(24-11,7-19-9-17-8-18-19)12-3-2-10(15)4-13(12)16/h2-4,8-9,11H,5-7H2,1H3/t11-,14+/s3
InChIKey QIMASXGTWQEFGS-LNBRXUOKNA-N
SMILES C(N1N=CN=C1)[C@]1(C2C=CC(Cl)=CC=2Cl)OC[C@H](COS(=O)(=O)C)O1 |&1:6,17,r|
CAS DataBase Reference 67914-86-7(CAS DataBase Reference)
FDA UNII T2I5SBS81M

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310+P330-P405-P501
REACH Registrations Active

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological D3531-93 cis-[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl-methyl)-1,3-dioxolan-4-yl]methyl Methanesulfonate 100mg $312 2026-06-03 Buy
Usbiological 271100 cis-[2-(2,4-Dichlorophenyl)-2-(1,2,4-triazol-1-yl-methyl)-1,3-dioxolan-4-yl]methyl methanesulfonate Asreported 67914-86-7 5g $389 2026-06-03 Buy
Usbiological 271100 cis-[2-(2,4-Dichlorophenyl)-2-(1,2,4-triazol-1-yl-methyl)-1,3-dioxolan-4-yl]methyl methanesulfonate Asreported 67914-86-7 10g $595 2026-06-03 Buy
Usbiological 271100 cis-[2-(2,4-Dichlorophenyl)-2-(1,2,4-triazol-1-yl-methyl)-1,3-dioxolan-4-yl]methyl methanesulfonate Asreported 67914-86-7 25g $797 2026-06-03 Buy
AK Scientific K116 cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol methanesulfonate 98%(HPLC) 67914-86-7 1g $29 2026-06-04 Buy
Product number Packaging Price Buy
D3531-93 100mg $312 Buy
271100 5g $389 Buy
271100 10g $595 Buy
271100 25g $797 Buy
K116 1g $29 Buy

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate Chemical Properties, Uses, Production

Chemical Properties

White-to-Off-White Powder

Uses

An intermediate in the synthesis of Itraconazole.

Synthesis

A preparation method for pharmaceutical intermediate cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate. The method comprises the following steps: (1) at first is raw material with the Meta Dichlorobenzene, carries out friedel-crafts reaction with bromoacetyl bromide; (2) then at heteropolyacid TiSiW 12O 40/ SiO 2Following and the glycerine condensation of catalysis; (3) with the Benzoyl chloride 99min. esterification; (4) under the catalysis of yellow soda ash, it is condensed with 1,2,4-triazole, then hydrolysed and recrystallised to yield cis-alcohol; (5) obtain product with the methylsulfonyl chloride esterification.Reaction equation is following:
Synthesis of cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate Preparation Products And Raw materials

Raw materials

Preparation Products

Paroxetine Itraconazole

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate Suppliers

Global Suppliers ( 218)
Supplier Tel Email Country ProdList Advantage
Sinfachem Limited 025-84683399 13952017251 sales@sinfachem.com China 215 56
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
XiaoGan ShenYuan ChemPharm co,ltd 15527621225; 15527621225 1791901229@qq.com China 6743 52
China Langchem Inc. 021-58956006,021-58950017 15800617331 sales@langchem.com China 209 57
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-4000505016 13380397412 3001272453@qq.com China 5000 50
HBCChem, Inc. +1-510-219-6317 sales@hbcchem.com United States 10628 60
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Supplier Advantage
Sinfachem Limited 56
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Chemsky（shanghai）International Co.,Ltd. 50
XiaoGan ShenYuan ChemPharm co,ltd 52
China Langchem Inc. 57
BOC Sciences 65
S.Z. PhyStandard Bio-Tech. Co., Ltd. 50
HBCChem, Inc. 60
Bide Pharmatech Ltd. 60

View Latest Price from cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
cis-[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate pictures 2026-09-15 cis-[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
67914-86-7
 $135.00 100g 0.99 25kg Shanghai UCHEM Inc.
cis-[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate pictures 2025-04-04 cis-[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
67914-86-7
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate pictures 2019-07-06 cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate
67914-86-7
 $1.00 1KG 98% 1 Career Henan Chemical Co

67914-86-7 (cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate) Related Search:

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1,3-Dioxolane Pefloxacin mesylate Methanesulfonic acid Imatinib Itraconazole
2-(2,4-Dichlorophenyl)-2-(1,2,4-triazol-1-yl methyl)-1,3-dioxalane-4-yl methyl methane sulfonate trans-Itraconazole N-Desalkyl Itraconazole Itraconazole Impurity 34 Butyl Itraconazole
KETO ITRACONAZOLE 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]- 1-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-4-(4-nitrophenyl)piperazine

1of4

2,4-dihydro-4-[[4-(4-hydroxyphenyl)-1-piperazinyl]-phenyl]-2-(1-methylpropyl)-3h-1,2,4-triazole-3-one Cis-trimesylate CIS-DTM 1-[[(2r,4s)-2-(2,4-dichlorophenyl)-4-(methylsulfonyloxymethyl)-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole 1,3-DIOXOLANE-4-METHANOL, 2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-METHANESULFONATE(ESTER),(2R,4R)-REL- CIS-[2-(2,4-DICHLOROPHENYL)-2-(1,2,4-TRIAZOL-1-YL-METHYL)-1,3-DIOXOLAN-4-YL]METHYL METHANESULPHONATE CIS-[2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL] METHYL METHANESULFATE CIS-[2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHYL METHANESULFONATE cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate Dichlorophenyl triazol ylmethyl dioxolan-yl methyl methanesulfonate 2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-methanol methanesulfonate (2R,4R)-rel-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolane-4-Methanol Methanesulfonate Itraconazole Dioxolonyl IMpurity DTM:cis-[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMeth Itraconazole Sulfonate IMpurity cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol,methanesulfonate(DTM) CIS-2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1,3-DIOXOLANE-4-METHANOL METHANESULFONATE cis-[2,4-dichlorophenyl)-2-(1h-1,2,4-triazol-1-yl-methyl)-1,3-dioxolan-4-yl]methyl methanesulfonate Cis-2-(2,4-DichloroPhenyl)-2(Ih-I,2,4-Triazol-L-Yl-Methy>>-L,3-Dioxolan-4-MethanolMethaneSulfonate,Itraconazole, CHLOROPHYLLIN (IN PASTE ) Cis-[2-(2,4-Dichlorophenyl)-2- CIS-[2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-METHYL)-1,3-DIOXOLANE-4-YL]-METHYL Cis-[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-Triazol-1-Ylmethyl)-1,3-Dioxolan-4-yl]me cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-y DTM:cis-[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methylmethanesulfonate CIS-[2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL] METHYL METHANESULFAT Cis-2-(2,4-Dichlorophenyl)-2-(1H-1,4-Triazole-1-Al- Methyl )1,3-Dioxalane-4-Methanol Methyl Sulfonate Itraconazole Impurity 14 1,3-Dioxolane-4-methanol,2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-, 4-methanesulfonate,(2R,4R)-rel- cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate CIS-DTM CIS-[[2-(2,4-DICHLORO PHENYL)-2-(1H-1,2,4 TRIAZOLE-1-YL METHYL)-1,3-DIOXOLAN-4-YL]METHYL]METHANE SULFONATE cis-[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl-methyl)-1,3-dioxolan-4-yl]methyl Methanesulfonate (cis-2-((1H-1,2,4-Triazol-1-yl)Methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)Methyl Methyl sulfate Cis Mesylate (Cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-6-ylmethyl methane sulphonate Itraconazole Impurity 8 cis-2-(2,4-Dichlorophenyl)-2-(1H-1, (cis-2-((1H-1,2,4-triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl methanesulfonate 2,4-Dihydro-4-[[4-(4-Hydroxyphenyl)-1-Piperazinyl]-Phenyl]-2... "(2R,4R)-rel-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol Metha" Cis-Mesylate (cis-2-(2,4- Dichlorophenyl) -2-(1H-1,2,4- triazol-1-ylmethyl)-1,3-dioxolan- 4-ylmethyl methanesulphonate)-S Itraconazole Impurity 26（Relative stereochemistry） cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1 rac,cis-[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate ITRACOZOLE HYDROXY ISOBUTYLTRIAZOLONE IMPURITY Cis-[2-(2,4 - Dichlorophenyl)-2-(lH- 1,2,4-Triazol-1-yl-Methyl)-1,3-Dioxolan- 4-yll Methyl Methanesulfonate ((4S)-2-((1H-1,2,4,-Triazole-1-yl)Methyl)-2-(2,4-Dichlorophenyl)-1,3-Dioxolan-4-yl)Methyl Methane Sulfonate ((2R,4R)-2-((1H-1,2,4-triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl methanesulfonate rac,cis-[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulf Cis-[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-Triazol-1-Yl-Methyl)-1,3-Dioxolan-4-Yl]Methyl Methane sulfonate [IT-9] (2R,4R)-rel-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol Methanes 2,4-Dihydro-4-[[4-(4-Hydroxyphenyl)-1-Piperazinyl]-Phenyl]-2-(1-Methylpropyl)-3H-1,2,4-Triazole-3-On cis-Methanesulfonicacid[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methylester cis-2-(2,4-Dichlorophenyl)-2-(1H-1, 2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol methane sulfonate (Cis-Mesylate) (IT-9) 67914-86-7 C14H15Cl2N3O5S C14H15N3O5Cl2S Pharmaceutical Intermediates INTERMEDIATESOFITRACONAZOLE