ChemicalBook >제품 카탈로그 >cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate 구조식 이미지

카스 번호:: 67914-86-7

상품명:: cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate

동의어(영문):: CIS-DTM;Cis-trimesylate;Itraconazole Impurity 8;Itraconazole Impurity 14;CHLOROPHYLLIN (IN PASTE );Cis-[2-(2,4-Dichlorophenyl)-2-;Itraconazole Sulfonate IMpurity;Itraconazole Dioxolonyl IMpurity;cis-2-(2,4-Dichlorophenyl)-2-(1H-1,;ITRACOZOLE HYDROXY ISOBUTYLTRIAZOLONE IMPURITY

CBNumber:: CB8282981

분자식:: C14H15Cl2N3O5S

포뮬러 무게:: 408.26

MOL 파일:: 67914-86-7.mol

속성

안전

용도

공급 업체 217

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate 속성

녹는점: 98 °C

끓는 점: 615.5±65.0 °C(Predicted)

밀도: 1.59±0.1 g/cm3(Predicted)

저장 조건: 2-8°C

용해도: 클로로포름(약간 용해됨), 에틸아세테이트(약간 용해됨), 메탄올(약간 용해됨)

용해도: 클로로포름(약간), 에틸아세테이트(약간), 메탄올(약간)에 용해됨

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 2.94±0.12(Predicted)

색상: 흰색에서 황백색까지

InChI: InChI=1/C14H15Cl2N3O5S/c1-25(20,21)23-6-11-5-22-14(24-11,7-19-9-17-8-18-19)12-3-2-10(15)4-13(12)16/h2-4,8-9,11H,5-7H2,1H3/t11-,14+/s3

InChIKey: QIMASXGTWQEFGS-LNBRXUOKNA-N

SMILES: C(N1N=CN=C1)[C@]1(C2C=CC(Cl)=CC=2Cl)OC[C@H](COS(=O)(=O)C)O1 |&1:6,17,r|

CAS 데이터베이스: 67914-86-7(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H301	삼키면 유독함	급성 독성 물질 - 경구	구분 3	위험		P264, P270, P301+P310, P321, P330,P405, P501

예방조치문구:

P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P270	이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P405	밀봉하여 저장하시오.
P501	...에 내용물 / 용기를 폐기 하시오.

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate C화학적 특성, 용도, 생산

화학적 성질

White-to-Off-White Powder

Synthesis

A preparation method for pharmaceutical intermediate cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate. The method comprises the following steps: (1) at first is raw material with the Meta Dichlorobenzene, carries out friedel-crafts reaction with bromoacetyl bromide; (2) then at heteropolyacid TiSiW 12O 40/ SiO 2Following and the glycerine condensation of catalysis; (3) with the Benzoyl chloride 99min. esterification; (4) under the catalysis of yellow soda ash, it is condensed with 1,2,4-triazole, then hydrolysed and recrystallised to yield cis-alcohol; (5) obtain product with the methylsulfonyl chloride esterification.Reaction equation is following:
Synthesis of cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate 준비 용품 및 원자재

원자재

준비 용품

파록세틴 Itraconazole

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate 공급 업체

글로벌( 217)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Sinfachem Limited	025-84683399 13952017251	sales@sinfachem.com	China	215	56
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6740	52
China Langchem Inc.	021-58956006,021-58950017 15800617331	sales@langchem.com	China	209	57
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
S.Z. PhyStandard Bio-Tech. Co., Ltd.	0755-4000505016 13380397412	3001272453@qq.com	China	5000	50
HBCChem, Inc.	+1-510-219-6317	sales@hbcchem.com	United States	10628	60
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate 관련 검색:

트리플루오로메탄술폰산 디클로로메틸페닐실란 디페닐디클로로실란 1,3-디옥살란 메탄술폰산 2-(2,4-디클로로페닐)-2-(1,2,4-TRIAZOL-1-YL메틸)-1,3-DIOXALANE-4-YL메틸메탄술폰산염 케토이트라코나졸 부틸이트라코나졸 N-데스알킬이트라코나졸 트랜스-이트라코나졸 4-([4-(4-메틸옥시-페닐)-피페라진-1-일]-페닐)-탄산페닐에스테르 4-(4-아미노페닐)피페라진-1-카르복실산tert-부틸에스테르 이소프로필이트라코나졸 (1,2,4-트리아졸-4-일)이트라코나졸 프로필이트라코나졸 1-(4-아미노페닐)-4-(4-메톡시페닐)피페라진 메탄술폰산메틸에스테르 1,3-디옥솔란-4-메탄올