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Ethyl 1-methylnipecotate

Ethyl 1-methylnipecotate structure

CAS No.: 5166-67-6

Chemical Name:: Ethyl 1-methylnipecotate

Synonyms: ETHYL 1-METHYLPIPERIDINE-3-CARBOXYLATE;NSC 64739;LABOTEST-BB LT00159658;ETHYL 1-METHYLNIPECOTATE;Ethyl 1-methylnipecotate, 98+%;1-Methyl-nipecotic acid ethyl ester;Ethyl-1-methylpiperidin-3-carboxylat;Ethyl N-Methylpiperidine-3-carboxylate;thyl N-methyl piperidine-3-carboxylate;ETHYL 1-METHYL-3-PIPERIDINE-CARBOXYLATE

CBNumber:: CB8289450

Molecular Formula:: C9H17NO2

Molecular Weight:: 171.24

MDL Number:: MFCD00006496

MOL File:: 5166-67-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:40:55

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Ethyl 1-methylnipecotate Properties

Boiling point	88-89 °C/11 mmHg (lit.)
Density	0.954 g/mL at 25 °C (lit.)
refractive index	n20/D 1.451(lit.)
Flash point	155 °F
storage temp.	Sealed in dry,Room Temperature
form	clear liquid
pka	8.56±0.10(Predicted)
color	Colorless to Almost colorless
BRN	123259
InChI	1S/C9H17NO2/c1-3-12-9(11)8-5-4-6-10(2)7-8/h8H,3-7H2,1-2H3
InChIKey	VFJJNMLPRDRTCO-UHFFFAOYSA-N
SMILES	CCOC(=O)C1CCCN(C)C1
CAS DataBase Reference	5166-67-6(CAS DataBase Reference)
NIST Chemistry Reference	Ethyl 1-methylnipecotate(5166-67-6)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37/39-37/39

WGK Germany

9-23

Hazard Note

Irritant

HS Code

29333990

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	2
2		0

Ethyl 1-methylnipecotate price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	194352	Ethyl 1-methyl-3-piperidinecarboxylate 96%	5166-67-6	5g	$92.4	2023-06-20	Buy
TCI Chemical	E0863	Ethyl 1-Methyl-3-piperidinecarboxylate >95.0%(GC)(T)	5166-67-6	5g	$45	2026-04-30	Buy
TCI Chemical	E0863	Ethyl 1-Methyl-3-piperidinecarboxylate >95.0%(GC)(T)	5166-67-6	25g	$123	2026-04-30	Buy
Biosynth	FAA16667	Ethyl 1-Methyl-3-piperidinecarboxylate	5166-67-6	0.25g	$250	2026-06-04	Buy
Biosynth	FAA16667	Ethyl 1-Methyl-3-piperidinecarboxylate	5166-67-6	2.5g	$855.5	2026-06-04	Buy

Product number	Packaging	Price	Buy
194352	5g	$92.4	Buy
E0863	5g	$45	Buy
E0863	25g	$123	Buy
FAA16667	0.25g	$250	Buy
FAA16667	2.5g	$855.5	Buy

Ethyl 1-methylnipecotate Chemical Properties, Uses, Production

Chemical Properties

Clear colorless to pale yellow liquid

Uses

Reactant for:
N-demethylation of tertiary amines
Reverse cope elimination reactions
Regioselective oxidation
Synthesis of chelating agents
Sequential Michael-Michael-Dieckmann cyclizations

General Description

Enantiomeric discrimination has been investigated in ¹H and ¹³C NMR spectra of ethyl 1-methyl-3-piperidinecarboxylate in the presence of (-)-(18-crown-6)-2,3,11,12-tetracarboxylic acid.

Synthesis

122-51-0

71962-74-8

5166-67-6

The general procedure for the synthesis of ethyl 1-methyl-3-piperidinecarboxylate from triethyl orthoformate and ethyl crotonate is as follows: in an autoclave, a 1 molar concentration of catalyst based on the molar amount of amine is added, and after displacing the air in the autoclave with argon, 0.1 moles of amine and 0.11-0.3 moles of o-carboxylic acid ester dissolved in a 10 ml solution in methanol (or ethanol) are added, as well as 0.5 ml of 0.2 M anhydrous p-toluene benzenesulfonic acid solution in methanol (or ethanol). The reaction mixture was heated to 120°C and charged with hydrogen gas to a pressure of 40 bar. The reaction mixture was stirred continuously at a constant pressure until the absorption of hydrogen ceased (reaction time of about 0.2-6 hours). After completion of the reaction, the catalyst was removed by filtration and the filtrate was distilled to purify the target product.

References

[1] Patent: WO2017/133913, 2017, A1. Location in patent: Page/Page column 9; 14

Ethyl 1-methylnipecotate Preparation Products And Raw materials

Raw materials

Triethyl orthoformate Ethyl nipecotate

Preparation Products

3-Piperidinemethanol,1-methyl-,(3R)-(9CI)

Ethyl 1-methylnipecotate Suppliers

Global Suppliers ( 193)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	0311-89250318 13582355795	master@sjzsdyn.com	China	2776	65
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	65
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Jia Xing Isenchem Co.,Ltd	66
Pure Chemistry Scientific Inc.	62

View Latest Price from Ethyl 1-methylnipecotate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-02	Ethyl 1-methylnipecotate 5166-67-6	$10.00-100.00	1kg	99%	5000 Metric Ton/Month	Wuhan Xinhao Biotechnology Co., Ltd
2023-09-11	thyl N-methyl piperidine-3-carboxylate 5166-67-6	$100.00	1bag	99	5000	Hebei Fengqiang Trading Co., LTD
2022-02-25	Ethyl 1-methylnipecotate 5166-67-6		1KG	98%	100	Jinan Ande Pharmaceutical Co.,Ltd.

Ethyl 1-methylnipecotate
5166-67-6
$10.00-100.00
99%
Wuhan Xinhao Biotechnology Co., Ltd

thyl N-methyl piperidine-3-carboxylate
5166-67-6
$100.00
99
Hebei Fengqiang Trading Co., LTD

Ethyl 1-methylnipecotate
5166-67-6
$0.00
98%
Jinan Ande Pharmaceutical Co.,Ltd.

Ethyl 1-methylnipecotate Spectrum

Ethyl 1-methylnipecotate(5166-67-6)MS Ethyl 1-methylnipecotate(5166-67-6)¹HNMR Ethyl 1-methylnipecotate(5166-67-6)¹³CNMR Ethyl 1-methylnipecotate(5166-67-6)IR1 Ethyl 1-methylnipecotate(5166-67-6)Raman

5166-67-6 (Ethyl 1-methylnipecotate) Related Search:

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Ethyl 1-methylnipecotate, 98+% 1-Methyl-3-piperidinecarboxylic acid ethyl ester ETHYL 1-METHYLNIPECOTATE ETHYL 1-METHYL-3-PIPERIDINE-CARBOXYLATE Ethyl 1-methylpiperidine-3-carboxylate 97% Ethyl N-Methyl piperidine-3-carboxylate or Ethyl 1-Methylnipecotate Ethyl N-Methylpiperidine-3-carboxylate 1-Methylnipecotic Acid Ethyl Ester Ethyl 1-Methylnipecotate 1-Methyl-3-piperidinecarboxylic Acid Ethyl Ester 1-Methyl-nipecotic acid ethyl ester NSC 64739 LABOTEST-BB LT00159658 3-Piperidinecarboxylic acid, 1-methyl-, ethyl ester 1-METHYL-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER Ethyl 1-methyl-3-piperidinecarboxylate cas 5166-67-6 Ethyl1-Methyl-3-piperidinecarboxylate> N-methylpiperidine-3-carboxylate, ethyl ester Ethyl-1-methylpiperidin-3-carboxylat thyl N-methyl piperidine-3-carboxylate ETHYL 1-METHYLPIPERIDINE-3-CARBOXYLATE 5166-67-6 Building Blocks Heterocyclic Building Blocks Piperidines Heterocyclic Compounds