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GSK-2256098

GSK-2256098 Structure
GSK-2256098 structure
CAS No.
1224887-10-8
Chemical Name:
GSK-2256098
Synonyms
CS-2424;GTPL7939;GSK-2256099;GSK-2256098;GSK-2256098, GTPL7939;GSK-2256098;GSK 2256098;FAK inhibitor GS2256098;GSK2256098, 10 mM in DMSO;2-(5-chloro-2-(1-isopropyl-3-methyl-1H-pyrazol-5-ylamino)pyridin-4-ylamino)-N-methoxybenzamide;2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-N(methyloxy)benzamide
CBNumber:
CB83044319
Molecular Formula:
C20H23ClN6O2
Molecular Weight:
414.89
MDL Number:
MFCD30502650
MOL File:
1224887-10-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-05 09:01:00
Request For Quotation

GSK-2256098 Properties

Density 1.32±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:47.33(Max Conc. mg/mL);114.08(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);72.31(Max Conc. mM)
Ethanol:56.0(Max Conc. mg/mL);134.98(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.48(Max Conc. mM)
form A crystalline solid
pka 5.24±0.10(Predicted)
color White to khaki
InChI InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23,24)
InChIKey BVAHPPKGOOJSPU-UHFFFAOYSA-N
SMILES C(NOC)(=O)C1=CC=CC=C1NC1C(Cl)=CN=C(NC2N(C(C)C)N=C(C)C=2)C=1
FDA UNII R7O0O4110G

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P280-P305+P351+P338-P310
NFPA 704
0
2 0

GSK-2256098 price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22955 GSK2256098 ≥98% 1224887-10-8 1mg $38 2026-04-30 Buy
Cayman Chemical 22955 GSK2256098 ≥98% 1224887-10-8 5mg $147 2026-04-30 Buy
Cayman Chemical 22955 GSK2256098 ≥98% 1224887-10-8 10mg $255 2026-04-30 Buy
Cayman Chemical 22955 GSK2256098 ≥98% 1224887-10-8 25mg $454 2026-04-30 Buy
ChemScene CS-6083 GSK2256098 99.86% 1224887-10-8 2mg $76 2026-06-04 Buy
Product number Packaging Price Buy
22955 1mg $38 Buy
22955 5mg $147 Buy
22955 10mg $255 Buy
22955 25mg $454 Buy
CS-6083 2mg $76 Buy

GSK-2256098 Chemical Properties, Uses, Production

Description

GSK2256098 is an inhibitor of focal adhesion kinase (FAK). It is selective for FAK, inhibiting only FAK greater than 50% in a panel of 261 kinases. GSK2256098 inhibits FAK autophosphorylation at tyrosine 397 (Y397) in OVCAR8 ovarian, U87MG glioblastoma, and A549 lung cancer cell lines (IC50s = 15, 8.5, and 12 nM, respectively). It induces apoptosis and increases PARP levels, decreases viability (IC50 = 25 μM), and inhibits colony formation in L3.6P1 cells. GSK2256098 (75 mg/kg per day) also leads to lower tumor weight and fewer metastases in the Ishikawa orthotopic mouse model of uterine cancer.

Uses

GSK 2256098 is FAK inhibitor. It can be used in biological study of molecular pathways: endothelial cell FAK-A target for cancer treatment.

Synthesis

Benzamide, 2-[(2,5-dichloro-4-pyridinyl)amino]-N-methoxy-

1201935-41-2

2-ISOPROPYL-5-METHYL-2 H-PYRAZOL-3-YLAMINE

1124-16-9

GSK-2256098

1224887-10-8

Example 4: 1a Synthesis of 2-((5-chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide 2-[(2,5-dichloro-4-pyridinyl)amino]-N-methoxybenzamide (70 mg, 0.224 mmol), 1-isopropyl-3-methyl-5-aminopyrazole (70 mg, 0.503 mmol) and cesium carbonate (230 mg, 0.706 mmol) were added sequentially to the microwave reaction tube. The reaction mixture was degassed with nitrogen for 10 min. BINAP (50 mg, 0.080 mmol) and palladium(II) acetate (10 mg, 0.045 mmol) were then added. The reaction mixture was placed in a microwave reactor and heated at 160 °C for 40 min. Upon completion of the reaction, the crude product was purified by reversed-phase high performance liquid chromatography (Gilson) using acetonitrile/water containing 0.1% formic acid as eluent to afford the target compound 2-((5-chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide (15 mg, 15% yield). Mass spectrum (MS): M(C20H23ClN6O2)=414.89, (M+H)+=415,416; 1H NMR (400 MHz, chloroform-d) δ ppm 9.42(br.s, 1H), 8.71(br.s, 1H), 8.02(s, 1H), 7.54(br.s., 1H), 7.06(t, J= 7.5 Hz, 1H), 6.48(s, 1H), 6.32(br.s., 1H), 5.86(s, 1H), 4.47(dt, J=13.4,6.7 Hz, 1H), 3.92(s, 3H), 2.26(s, 3H), 1.41-1.43(d, J=6.6Hz, 6H).

in vivo

FAK is well-known to play an important role in angiogenesis, proliferation, and apoptosis, so the tumor samples harvested from the therapy experiments are examined. Evaluating CD31, significantly lower microvessel densities in tumors from mice treated with GSK2256098 and Paclitaxel is observed than in tumors from mice in the vehicle control group (P<0.05). This is consistent across both models, but Ishikawa tumors had the lowest microvessel density. All tumor models in mice treated with GSK2256098 exhibit less proliferation via Ki67 than control. Ishikawa tumors have the lowest Ki67 expression in response to therapy. Ishikawa tumors have higher apoptotic indices than Hec1A tumors after treatment with GSK2256098. Significant rates of apoptosis are seen in all models that had been treated with combination GSK2256098 and Paclitaxel[2].

storage

Store at -20°C

References

[1] Patent: US2010/113475, 2010, A1. Location in patent: Page/Page column 23-24
[2] Patent: WO2013/3575, 2013, A1. Location in patent: Page/Page column 53

GSK-2256098 Preparation Products And Raw materials

Raw materials

Benzamide, 2-[(2,5-dichloro-4-pyridinyl)amino]-N-methoxy- 2-Isopropyl-5-methyl-2 H-pyrazol-3-ylamine

Preparation Products

GSK-2256098 Suppliers

Global Suppliers ( 122)
Supplier Tel Email Country ProdList Advantage
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9831 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29977 65
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4773 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
AdooQ Bioscience CHINA 025-58849295 info@adooq.cn China 2981 60
Shanghai YuanQi Biotechnology Co., Ltd. +86-2332782371 +86-18120098618 sales@adobechem.com China 1250 50
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
D&C Chemicals +86-21-58447131 1724405207@qq.com China 470 55
Supplier Advantage
RD International Technology Co., Limited 58
Shanghai Boyle Chemical Co., Ltd. 55
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Guangzhou Isun Pharmaceutical Co., Ltd 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Bide Pharmatech Ltd. 60
AdooQ Bioscience CHINA 60
Shanghai YuanQi Biotechnology Co., Ltd. 50
Shanghai Lollane Biological Technology Co.,Ltd. 55
D&C Chemicals 55

View Latest Price from GSK-2256098 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GSK2256098 pictures 2026-07-27 GSK2256098
1224887-10-8
 $39.00-81.00 99.74% 10g TargetMol Chemicals Inc.
  • GSK2256098 pictures
  • GSK2256098
    1224887-10-8
  • $39.00-81.00
  • 99.74%
  • TargetMol Chemicals Inc.

GSK-2256098 Spectrum

GSK-2256098(1224887-10-8)1HNMR

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1of4

GSK-2256098 2-(5-chloro-2-(1-isopropyl-3-methyl-1H-pyrazol-5-ylamino)pyridin-4-ylamino)-N-methoxybenzamide GTPL7939 Benzamide, 2-[[5-chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxy- 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-N(methyloxy)benzamide CS-2424 FAK inhibitor GS2256098 GSK-2256098;GSK 2256098 GSK-2256099 GSK-2256098, GTPL7939 GSK2256098, 10 mM in DMSO 1224887-10-8 Inhibitors APIs