DBCO-PEG5-NHS ester
- CAS No.
- 1378531-80-6
- Chemical Name:
- DBCO-PEG5-NHS ester
- Synonyms
- DBCO-PEG5-PA-NHS;DBCO-PEG5-NHS ester;DBCO-NHCO-PEG5-NHS ester;DBCO-PEG5-NHS Ester (CCT-A102P);DBCO-NH-PEG4-CH2CH2COONHS ester;Azadibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester;4,7,10,13,16-Pentaoxa-20-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-19,23-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester;2,5-dioxopyrrolidin-1-yl 1-[(3-{2-azatricyclo[10.4.0.0\\u2074,\\u2079]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-3-oxopropyl)carbamoyl]-3,6,9,12,15-pentaoxaoctadecan-18-oate
- CBNumber:
- CB83062467
- Molecular Formula:
- C36H43N3O11
- Molecular Weight:
- 693.74
- MDL Number:
- MFCD28334547
- MOL File:
- 1378531-80-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
DBCO-PEG5-NHS ester price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-D194998-2MG | DBCO-PEG5-NHS ester | 1378531-80-6 | 2mg | $98 | 2026-06-03 | Buy |
| TRC | TRC-D194998-1MG | DBCO-PEG5-NHS ester | 1378531-80-6 | 1mg | $73 | 2026-06-03 | Buy |
| TRC | TRC-D194998-10MG | DBCO-PEG5-NHS ester | 1378531-80-6 | 10mg | $304 | 2026-06-03 | Buy |
| Biosynth | DFC53180 | DBCO-PEG5-NHS ester | 1378531-80-6 | 1mg | $162.25 | 2026-06-04 | Buy |
| Biosynth | DFC53180 | DBCO-PEG5-NHS ester | 1378531-80-6 | 2mg | $259.6 | 2026-06-04 | Buy |
DBCO-PEG5-NHS ester Chemical Properties, Uses, Production
Description
DBCO-NHCO-PEG5-NHS ester is a PEG linker containing NHS ester that is able to react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and can also provide a long and flexible connection that minimizes steric hindrance during ligation. DBCO is commonly used for copper-free Click Chemistry reactions.
Uses
DBCO-NHCO-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-NHCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
DBCO-PEG5-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
DBCO-PEG5-NHS ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tongling HengYou Biotechnology Co., Ltd. | 021-50426030 13856289449;13124863828 | 2630597085@qq.com | China | 1885 | 55 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80534353 19917294565 | et@chemextension.com | China | 3904 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6347 | 58 | |
| Shanghai 9i Technology Co., Ltd. | 021-33555271 18201009191 | MWen@9iLab.com | China | 133 | 58 |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4229 | 58 |
| Jiangsu aikang biomedical research and development co., LTD | 025-58859352 17714375163 | qzhang@aikonchem.com | China | 15525 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shaanxi Xinyan Bomei Biotechnology Co., Ltd. | 13892832556 | 2440688701@qq.com | China | 1977 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39866 | 58 |
View Latest Price from DBCO-PEG5-NHS ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-07 | DBCO-NHCO-PEG5-NHS ester
1378531-80-6
|
50mg | >98.00% | 250mg | Xian confluore Biological Technology Co., Ltd. |
-
- DBCO-NHCO-PEG5-NHS ester
1378531-80-6
- $0.00
- >98.00%
- Xian confluore Biological Technology Co., Ltd.
