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ChemicalBook >> CAS DataBase List >>tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate

tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate

tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate Structure
tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate structure
CAS No.
956136-85-9
Chemical Name:
tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate
Synonyms
4-(N-BOC-Piperidino)phenylboronic acid pinacol ester;Phenyl]-Piperidine-1-Carboxylic Acid Tert-Butyl Ester;4-(1-Boc-4-piperidyl)phenylboronic Acid Pinacol Ester;4-(N-Boc-piperidin-4-yl)phenylboronic acid pinacol ester;1-Piperidinecarboxylic acid, 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxabo;tert-butyl 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidine-1-carboxylate;tert-Butyl 4-(4-(4,4,5-trimethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate;ert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate;tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate;4-[4-(4,4,5-Trimethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester
CBNumber:
CB83070840
Molecular Formula:
C22H34BNO4
Molecular Weight:
387.32
MDL Number:
MFCD16652353
MOL File:
956136-85-9.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:44
Product description Number Pack Size Price
tert-butyl4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate 3255AQ 1g $855.2
tert-Butyl4-(4-(4,4,5-trimethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate 956136859 5g $1671.55
tert-Butyl4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate 97% A205601 250mg $167
tert-Butyl4-(4-(4,4,5-trimethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate 956136859 250mg $216.58
tert-Butyl4-(4-(4,4,5-trimethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate 97% CD11003781 1g $412
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tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate Properties

Boiling point 480.6±45.0 °C(Predicted)
Density 1.07±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -1.69±0.40(Predicted)
Appearance White to off-white Solid

tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AK Scientific 3255AQ tert-butyl4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate 956136-85-9 1g $855.2 2021-12-16 Buy
Alichem 956136859 tert-Butyl4-(4-(4,4,5-trimethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate 956136-85-9 5g $1671.55 2021-12-16 Buy
Ambeed A205601 tert-Butyl4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate 97% 956136-85-9 250mg $167 2021-12-16 Buy
Alichem 956136859 tert-Butyl4-(4-(4,4,5-trimethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate 956136-85-9 250mg $216.58 2021-12-16 Buy
Crysdot CD11003781 tert-Butyl4-(4-(4,4,5-trimethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate 97% 956136-85-9 1g $412 2021-12-16 Buy
Product number Packaging Price Buy
3255AQ 1g $855.2 Buy
956136859 5g $1671.55 Buy
A205601 250mg $167 Buy
956136859 250mg $216.58 Buy
CD11003781 1g $412 Buy

tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate Chemical Properties,Uses,Production

Synthesis

1-N-BOC-4-(4-BROMOPHENYL)PIPERIDINE

769944-78-7

Bis(pinacolato)diboron

73183-34-3

tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate

956136-85-9

The general procedure for the synthesis of 4-(1-Boc-4-piperidinyl)phenylboronic acid pinacol ester from 1-N-Boc-4-(4-bromophenyl)piperidine and pinacol ester of boronic acid was as follows: in a pressure tube, a dioxane solution of tert-butyl 4-(4-bromophenyl)piperidine-1-carboxylate (1363 mg, 4.006 mmol) was purified with bis(pinacolato)diboron (1526 mg , 6.009 mmol), KOAc (1179 mg, 12.02 mmol) and PdCl2(dppf)-DCM (327.1 mg, 0.4006 mmol) treatment. The mixture was bubbled with nitrogen for 1 min, then sealed and heated at 100 °C overnight. After the reaction mixture was cooled to ambient temperature, it was diluted with a mixture of EtOAc (75 mL), water (50 mL), and brine (25 mL), and the resulting emulsion was filtered through Celite and washed with EtOAc. The two-phase filtrate was separated and the organic phase was washed with brine, dried (MgSO4), filtered and concentrated in vacuum. Purification of the crude product by silica gel chromatography (0-50% EtOAc/hexane) afforded 4-(1-Boc-4-piperidinyl)phenylboronic acid pinacol ester (1437 mg, 93% yield).1H NMR (CDCl3) δ 7.76 (d, 2H), 7.22 (m, 2H), 4.24 (d, 2H), 2.79 (dt, 2H), 2.65 ( tt, 1H), 1.81 (m, 2H), 1.63 (dq, 2H), 1.48 (s, 9H), 1.33 (s, 12H).

References

[1] Patent: WO2017/11776, 2017, A1. Location in patent: Paragraph 00701
[2] Patent: WO2017/114497, 2017, A1. Location in patent: Page/Page column 339
[3] Patent: WO2018/59549, 2018, A1. Location in patent: Page/Page column 293
[4] Patent: WO2007/126957, 2007, A2. Location in patent: Page/Page column 101
[5] Patent: WO2009/7390, 2009, A2. Location in patent: Page/Page column 96

tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

1-N-BOC-4-(4-BROMOPHENYL)PIPERIDINE Bis(pinacolato)diboron Pinacolborane Potassium Acetate 1,4-Dioxane

Preparation Products

tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate Suppliers

Global( 45)Suppliers
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Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30228 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 24597 58
Shanghai Scochem Technology Co., Ltd 		+86-021-33758897 +86-13701882790 sales@scochem.com China 1977 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 43333 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323658 +86-18168183658 sales1@artkmedchem.com China 39002 58
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Accela ChemBio Co.,Ltd. 021-50795510 4000665055 sales@accelachem.com China 11032 64
Supplier Advantage
Accela ChemBio Inc. 		58
Career Henan Chemica Co 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Shanghai Scochem Technology Co., Ltd 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Compound Net Biotechnology Inc. 		58
Amadis Chemical Company Limited 		58
BeiJing Hwrk Chemicals Limted 55
Accela ChemBio Co.,Ltd. 64

tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate Spectrum

tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate(956136-85-9)1HNMR

956136-85-9(tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate)Related Search:

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1of3

tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate 1-Piperidinecarboxylic acid, 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, 1,1-dimethylethyl ester 4-(1-Boc-4-piperidyl)phenylboronic Acid Pinacol Ester tert-Butyl 4-(4-(4,4,5-trimethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate 1-Piperidinecarboxylic acid, 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxabo ert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate 4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester 4-[4-(4,4,5-Trimethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester Phenyl]-Piperidine-1-Carboxylic Acid Tert-Butyl Ester tert-butyl 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidine-1-carboxylate 4-(N-BOC-Piperidino)phenylboronic acid pinacol ester 4-(N-Boc-piperidin-4-yl)phenylboronic acid pinacol ester 956136-85-9 C22H34BNO4