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Pinacolborane

Pinacolborane Structure
Pinacolborane structure
CAS No.
25015-63-8
Chemical Name:
Pinacolborane
Synonyms
HBpin;4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE;PINB;4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane;Pinacolatoborane;DK697;Nachoborane;PINACOLBORANE;Pinacolboronane;Pinacolborane 1
CBNumber:
CB8745950
Molecular Formula:
C6H13BO2
Molecular Weight:
127.98
MDL Number:
MFCD00674030
MOL File:
25015-63-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:26:36
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Pinacolborane Properties

Boiling point 42-43 °C50 mm Hg(lit.)
Density 0.882 g/mL at 25 °C(lit.)
vapor pressure 29-119.9hPa at 20-50℃
refractive index n20/D 1.396(lit.)
Flash point 41 °F
storage temp. 2-8°C
solubility Miscible with ether, dichloromethane, tetrahydrofuran and organic solvents.
form Liquid
Specific Gravity 0.882
color Clear colorless to light yellow
Sensitive Air Sensitive
BRN 7802871
Stability Air Sensitive, Hygroscopic, Moisture Sensitive
InChI InChI=1S/C6H13BO2/c1-5(2)6(3,4)9-7-8-5/h7H,1-4H3
InChIKey UCFSYHMCKWNKAH-UHFFFAOYSA-N
SMILES O1C(C)(C)C(C)(C)OB1
CAS DataBase Reference 25015-63-8(CAS DataBase Reference)
UNSPSC Code 12352103
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)
GHS02
Signal word  Danger
Hazard statements  H225-H261
Precautionary statements  P210-P231+P232-P233-P280-P302+P335+P334-P370+P378
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  F,Xi,Xn
Risk Statements  11-15-36/37/38-36/37-19-40
Safety Statements  16-43-8-37/39-26-33-29-36/37
RIDADR  UN 3398 4.3/PG 2
WGK Germany  3
Hazard Note  Highly Flammable/Keep Cold/Air Sensitive
HazardClass  4.3
PackingGroup  II
HS Code  29209090
Storage Class 4.3 - Hazardous materials which set free flammable gases upon contact with water
Hazard Classifications Flam. Liq. 2
Water-react 2
REACH Registrations Active
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
3
2 2
W

Pinacolborane price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 458945 4,4,5,5-Tetramethyl-1,3,2-dioxaborolane solution 1.0 M in THF 25015-63-8 4x25ml $389 2026-04-30 Buy
Sigma-Aldrich 458945 4,4,5,5-Tetramethyl-1,3,2-dioxaborolane solution 1.0 M in THF 25015-63-8 100ml $389 2026-04-30 Buy
TCI Chemical T2572 4,4,5,5-Tetramethyl-1,3,2-dioxaborolane >97.0%(GC) 25015-63-8 5g $44 2026-04-30 Buy
TCI Chemical T2572 4,4,5,5-Tetramethyl-1,3,2-dioxaborolane >97.0%(GC) 25015-63-8 25g $131 2026-04-30 Buy
Usbiological 286936 Pinacolborane 25015-63-8 10g $333 2026-06-03 Buy
Product number Packaging Price Buy
458945 4x25ml $389 Buy
458945 100ml $389 Buy
T2572 5g $44 Buy
T2572 25g $131 Buy
286936 10g $333 Buy

Pinacolborane Chemical Properties, Uses, Production

Chemical Properties

Clear colorless liquid

Uses

Pinacolborane is used for synthesis of unsymmetrical biaryls via aromatic C-H borylation-cross-coupling sequence.

Uses

Pinacolborane is used as a precursor of boronic esters by hydroboration or coupling reactions. It acts as a monofunctional hydroborating agent. It is used in the synthesis of unsymmetrical biaryls through aromatic C-H borylation-cross-coupling sequence. It is involved in the preparation of 4,4,5,5-tetramethyl-2-thiophen-2-yl-[1,3,2]dioxaborolane by reacting with 2-iodo-thiophene. Further, it is used to prepare vinylboronates by palladium-catalyzed coupling with alkenyl triflates and iodides.

Synthesis

Pinacol (177 g, 1.5 mol) and CH2Cl2 (1.6 L) were added to a 5 L round bottom flask. Borane dimethyl sulfide (10 M, 159 mL, 0.16 mol) was added to the flask via cannula and the mixture was stirred at 0C for 4 hours. The reaction mixture was then heated to room temperature overnight with stirring.17 After 17 h, the reaction mixture gave off some gas (hydrogen); however, the reaction was heated and slowly depressurized (760 mm to 200 mm). This process allowed CH2Cl2 (1.3 L) to move away from the reaction. The remaining liquid was transferred to a 500 mL flask through a cannula and the pressure was slowly reduced from atmospheric to 50 mm over 2.5 h. Some initial foaming was observed in the viscous liquid due to continued outgassing. The method provided pinacol borane suitable for subsequent reactions. The yield was 157 g, 81.7%.

Pinacolborane Preparation Products And Raw materials

Raw materials

Pinacol Borane-methyl sulfide complex Dichloromethane

Preparation Products

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 3-Morpholinophenylboronic acid pinacol ester 2-Ethoxycarbonylphenylboronic acid pinacol ester 4-Hydroxyphenylboronic acid pinacol ester BISPINACOLATOBIBORATE
1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-[(4-methylphenyl)methoxy]- 1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-(phenylmethoxy)- 4-Nitrophenylboronic acid pinacol ester 1-Boc-pyrazole-4-boronic acid pinacol ester 2-Amino-5-fluorophenyl boronic acid pinacol ester
2-Amino-5-fluorobenzeneboronic acid 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate 2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 2-(3,4-Dihydro-2H-pyran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
4-(N-Methylamino)phenylboronic acid, pinacol ester

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Pinacolborane Suppliers

Global Suppliers ( 258)
Supplier Tel Email Country ProdList Advantage
Shanghai Forxine Pharmaceutical Co., Ltd. 21-21-64961388 18918697718 service@forxine.com China 65 60
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2202 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Beijing Donghualituo Techonlogy Development Co.,Ltd. 010-88425576 sales@dhltchem.com China 793 59
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9409 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44566 61
Supplier Advantage
Shanghai Forxine Pharmaceutical Co., Ltd. 60
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Beijing Donghualituo Techonlogy Development Co.,Ltd. 59
INTATRADE GmbH 66
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61

View Latest Price from Pinacolborane manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pinacolborane pictures 2025-04-04 Pinacolborane
25015-63-8
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
Pinacolborane pictures 2023-08-31 Pinacolborane
25015-63-8
 $100.00 1bag 99 5000 Hebei Fengqiang Trading Co., LTD
Pinacolborane pictures 2021-09-02 Pinacolborane
25015-63-8
 $29.99 1KG 99% 50ton Hubei Aumei New Material Co., Ltd.
  • Pinacolborane pictures
  • Pinacolborane
    25015-63-8
  • $100.00
  • 99
  • Hebei Fengqiang Trading Co., LTD
  • Pinacolborane pictures
  • Pinacolborane
    25015-63-8
  • $29.99
  • 99%
  • Hubei Aumei New Material Co., Ltd.

Pinacolborane Spectrum

Pinacolborane(25015-63-8)1HNMRPinacolborane(25015-63-8)FT-IR

25015-63-8 (Pinacolborane) Related Search:

Methyl cyclopentenolone 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Bis(pinacolato)diboron Diborane 1,3-Dioxolane
1,4-Dioxane Borane-tetrahydrofuran complex Methoxydiethylborane Methylcyclopentadiene dimer Pentaborane
4-Carboxylphenylboronic acid pinacol ester 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline Allylboronic acid pinacol ester 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol Methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate
4'-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)acetanilide (2-Bromomethylphenyl)boronic acid, pinacol ester 2-Furanboronic acid pinacol ester

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TetraMethyl-1,3,2-dioxab Pinacolborane, 97%, stabilized 4,4,5,5-TetraMethyl-1,3,2-dioxaborolane 97% 4,4,5,5-TetraMethyl-1,3,2-dioxaborolane solution 1.0 M in THF Pinacolborane (4,4,5,5-Tetramethyl-1,3,2-dioxaborolane) PINACOLBORANE 4,4,5,5-Tetramethyl-1,3,2-dioxaborolane,Pinacolborane Pinacolboronane 4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE, 1M SOLUTION IN TETRAHYDROFURAN 1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl- 4,4,5,5-tetramethyl-1,3,2-dioxaborolane solution Pinacolborane (PINB) 4,4,5,5-TETRAMETHYL-1,3,2-DIOXA- & 4,4,5,5-Tetramethyl-1,3-dioxa-2$l^{2}-boracyclopentane 4,4,5,5-Tetramethyl-1,3,2-dioxaborole 4,4,5,5-Tetramethyl-1,3-dioxa-2-boracyclopentane Pinacolborane,97% 4,4,5,5-tetramethyl-1,3,2λ2-dioxaborolane Pinacolborane, 1.0 M in THF, J&KSeal 4,4,5,5-Tetramethyl-1,3,2-dioxaborolane solution,Pinacolborane Pinacolborane, 97%, for synthesis 4,4,5,5-tetramethyl-1,3,2λsup2sup-dioxaborolane Pinacolborane 1 4,4,5,5-tetramethyl-1,3,2 Nachoborane DK697 4,4,5,5-tetramethyl-1,3,2$l^{2}-dioxaborolane 4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane HBpin Pinacolatoborane PINB 25015-63-8 250015-63-8 Organometallic Reagents Boronic Acids and Derivatives Borylation Reagents Boron Derivatives Heterocycles