ChemicalBook >> CAS DataBase List >>Loxoprofen
Loxoprofen
- CAS No.
- 68767-14-6
- Chemical Name:
- Loxoprofen
- Synonyms
- IOXOPROFEN;2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid;2-[4-(2-OXO-CYCLOPENTYLMETHYL)-PHENYL]-PROPIONIC ACID;A-METHYL-4-[(2-OXOCYCLOPENTYL)METHYL]BENZENEACETIC ACID;KOLOXO;LOXOPROFEN;Loxoprofene;Loxoprofeno;Loxoprofen-d6;Loxoprofen RS
- CBNumber:
- CB8311755
- Molecular Formula:
- C15H18O3
- Molecular Weight:
- 246.31
- MDL Number:
- MFCD00864331
- MOL File:
- 68767-14-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-14 16:49:18
| Melting point | 108.5-111° |
|---|---|
| Boiling point | bp0.3 190-195° |
| Density | 1.182±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | solid |
| pka | 4.39±0.10(Predicted) |
| color | White to Off-White |
| Merck | 14,5589 |
| InChI | InChI=1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18) |
| InChIKey | YMBXTVYHTMGZDW-UHFFFAOYSA-N |
| SMILES | C(C1CCCC1=O)C1C=CC(C(C)C(=O)O)=CC=1 |
| CAS DataBase Reference | 68767-14-6(CAS DataBase Reference) |
| FDA UNII | 3583H0GZAP |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HS Code | 2918.99.3000 |
| Storage Class | 11 - Combustible Solids |
Loxoprofen price More Price(75)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L0664 | Loxoprofen | 68767-14-6 | 5mg | $425 | 2026-04-30 | Buy |
| TCI Chemical | L0244 | Loxoprofen >97.0%(HPLC)(T) | 68767-14-6 | 5g | $77 | 2026-04-30 | Buy |
| TRC | TRC-L472905-25MG | Loxoprofen >95%(HPLC) | 68767-14-6 | 25mg | $145 | 2026-06-03 | Buy |
| TRC | TRC-L472905-1G | Loxoprofen >95%(HPLC) | 68767-14-6 | 1g | $414 | 2026-06-03 | Buy |
| TRC | TRC-L472905-100MG | Loxoprofen >95%(HPLC) | 68767-14-6 | 100mg | $271 | 2026-06-03 | Buy |
Loxoprofen Chemical Properties, Uses, Production
Uses
antiinflammatory, analgesic
Uses
Loxoprofen is a non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation. Loxoprofen becomes active after metabolism in the body and inhibits the activation of cyclooxygenase.
Definition
ChEBI: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted to its active trans-alcohol metabolite following ora administration.
Synthesis
Ethyl 2-oxocyclopentanecarboxylate and potassium hydroxide in dimethylformamide were reacted with ethyl 2-(4-chloro-phenyl)propionate at 80 C for 2 h. The product obtained was reacted with 47% hydrobromic acid and hydrolyzed and decarboxylated to give loxoprofen.
Loxoprofen Preparation Products And Raw materials
Raw materials
Preparation Products
Global Suppliers ( 389)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Jiecheng Pharmaceutical Co., Ltd | 0531-83130525 18560095177 | lily.chen@jiechengpharm.com | China | 25 | 58 |
| Wudi Rongchuan Pharmaceutical and Chemical Technology Co., Ltd. | 021-5147-3705 17852115892 | wxj@yananpharm.com | China | 64 | 58 |
| Suzhou Ryway Biotech Co., Ltd | 180-1316-0973 | rywaybio@gmail.com | China | 294 | 55 |
| Guangzhou Dreampharm Biotechnology Co., Ltd. | 020-36607679; 13502246435 | 3008233746@qq.com | China | 9961 | 12 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
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- Sep 8,2025
View Latest Price from Loxoprofen manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | Loxoprofen Acid
68767-14-6
|
1KG | 99%min | 500kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | Loxoprofen
68767-14-6
|
$5.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-21 | Loxoprofen
68767-14-6
|
$95.00-100.00 | 1kg | 99.99% | 100Tons | Hebei Dangtong Import and export Co LTD |
-
- Loxoprofen Acid
68767-14-6
- $0.00
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Loxoprofen
68767-14-6
- $5.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Loxoprofen
68767-14-6
- $95.00-100.00
- 99.99%
- Hebei Dangtong Import and export Co LTD
68767-14-6 (Loxoprofen) Related Search:
2-[4-[(2-Oxocyclopentan-1-yl)methyl]phenyl]propionic acid
KOLOXO
LOXOPROFEN
2-[4-(2-OXO-CYCLOPENTYLMETHYL)-PHENYL]-PROPIONIC ACID
A-METHYL-4-[(2-OXOCYCLOPENTYL)METHYL]BENZENEACETIC ACID
α-methyl-4-[(2-oxocyclopentyl)methyl]benzeneacetic acid
2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid
ALPHA-METHYL-4-[(2-OXOCYCLOPENTYL)METHYL]BENZENEACETIC ACID
Benzeneacetic acid, a-methyl-4-[(2-oxocyclopentyl)methyl]- (9CI)
Loxoprofen (base and/or unspecified salts)
α-Methyl-4-[(2-oxocyclopentyl)methyl]benzeneacetic acid, Koloxo
Loxoprofen (high-melting polymorph)
Loxoprofen (low-melting polymorph)
2-[p-(2-Oxocyclopentylmethyl)phenyl]propionic acid
2-[4-[(2-ketocyclopentyl)methyl]phenyl]propionic acid
Loxoprofen USP
Loxoprofen See L472900
Benzeneacetic acid, a-Methyl-4-[(2-oxocyclopentyl)Methyl]-
Loxoprofen-d6
Loxoprofen RS
Loxoprofene
Loxoprofeno
Benzeneacetic acid, α-methyl-4-[(2-oxocyclopentyl)methyl]-
Loxoprofen USP/EP/BP
Loxoprofen (10mM in DMSO)
Loxoprofen Impurity 67
Loxoprofen Impurity 68
Loxoprofen D7
Loxoprofen-d3Q: What is
Loxoprofen-d3 Q: What is the CAS Number of
Loxoprofen-d3
Loxoprofen API
2-(4-((2-(hydroxymethyl)-1,4-dioxaspiro[4.4]nonan-6-yl)methyl)phenyl)propanoic acid
4-hydroxybutan-2-yl 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate
butane-1,3-diyl bis(2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate)
D4-Loxoprofen
Loxoprofen Precursor
Loxoprofen Sodium Precursor
2-(4-((2-oxyclopentyl)methyl)phenyl)propanoic acid
IOXOPROFEN
68767-14-6
LOXONIN
Active Pharmaceutical Ingredients
