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Suprafenacine

Suprafenacine Structure
Suprafenacine structure
CAS No.
1477482-50-0
Chemical Name:
Suprafenacine
Synonyms
Suprafenacine;Suprafenacine >=98% (HPLC);Suprafenacine, 10 mM in DMSO;N'-[(E)-(4-methylphenyl)methylidene]-4;7-tetrahydro-1H-indazole-3-carbohydrazide;4,5,6,7-TETRAHYDRO-1H-INDAZOLE-3-CARBOXYLIC ACID (4-METHYL-BENZYLIDENE)HYDRAZIDE;N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide;N-[(E)-(4-methylphenyl)methylideneamino]-4,5,6,7-tetrahydro-1~{H}-indazole-3-carboxamide;1H-Indazole-3-carboxylic acid, 4,5,6,7-tetrahydro-, (2E)-2-[(4-methylphenyl)methylene]hydrazide
CBNumber:
CB83146392
Molecular Formula:
C16H18N4O
Molecular Weight:
282.34
MDL Number:
MFCD01913314
MOL File:
1477482-50-0.mol
MSDS File:
SDS
Last updated:2026-07-28 20:33:00
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Suprafenacine Properties

Density 1.284±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. Store at -20°C
solubility DMSO: 10 mg/ml
form A solid
pka 12.107±0.20(predicted)
color White to off-white

Suprafenacine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 31158 Suprafenacine ≥98% 1477482-50-0 1mg $36 2026-04-30 Buy
Cayman Chemical 31158 Suprafenacine ≥98% 1477482-50-0 5mg $120 2026-04-30 Buy
Cayman Chemical 31158 Suprafenacine ≥98% 1477482-50-0 10mg $219 2026-04-30 Buy
ChemScene CS-0068390 Suprafenacine 98.0% 1477482-50-0 1mg $114 2026-06-04 Buy
ChemScene CS-0068390 Suprafenacine 98.0% 1477482-50-0 5mg $276 2026-06-04 Buy
Product number Packaging Price Buy
31158 1mg $36 Buy
31158 5mg $120 Buy
31158 10mg $219 Buy
CS-0068390 1mg $114 Buy
CS-0068390 5mg $276 Buy

Suprafenacine Chemical Properties, Uses, Production

Uses

Suprafenacine is a cell permeable, tubulin-destabilizing molecule which bind microtubules at the colchicine-binding site and inhibit polymerization. Suprafenacine can induce G2/M cell cycle arrest and apoptosis, and can be used for cancer research[1].

Biological Activity

Suprafenacine is an inhibitor of tubulin polymerization (IC50 = 0.38 μM) with anticancer activity.1 It inhibits the proliferation of HeLa, Jurkat, SNU-16, MDA-MB-231, A549, SH-SY5Y, HCT15, and KB-3-1 cells (IC50s = 83-381.2 nM) and P-glycoprotein-enriched KB-VI cells (IC50 = 215.7 nM). Suprafenacine (10 μM) increases phosphorylation of JNK and Bcl-2 and induces apoptosis and cell cycle arrest at the G2/M phase in HeLa cells. Suprafenacine (20 mg/kg) reduces tumor growth in an HCT15 colon adenocarcinoma mouse xenograft model.

in vivo

Suprafenacine (20 mg/kg, i.p., every 3 days for 9 days) suppresses 40% of tumor mass in HCT15 tumor bearing SCID mice compared with control mice[1].

References

1.Choi, B.-H., Chattopadhaya, S., Thanh, L.N., et al.Suprafenacine, an indazole-hydrazide agent, targets cancer cells through microtubule destabilizationPLoS One9(10)e110955(2014)

Suprafenacine Preparation Products And Raw materials

Raw materials

Preparation Products

Suprafenacine Suppliers

Global Suppliers ( 23)
Supplier Tel Email Country ProdList Advantage
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2994 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Jinan ponder chemical co. LTD 0531-0000 thinklifescience@163.com China 19684 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Energy Chemical 400-0056266 marketing1@energy-chemical.com China 44927 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 11975 58
Shanghai Amole Biotechnology Co., Ltd. 13370042665 18916960931 2596183085@qq.com China 17234 58
Guangzhou Ruidi Biotechnology Co., Ltd. 020-82099279 18988941402 sales@ubiochem.com China 9998 58
Supplier Advantage
Shanghai Beckham Medical Technology Co., Ltd 55
Shanghai EFE Biological Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Jinan ponder chemical co. LTD 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
TargetMol Chemicals Inc. 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
Shanghai Amole Biotechnology Co., Ltd. 58
Guangzhou Ruidi Biotechnology Co., Ltd. 58

View Latest Price from Suprafenacine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Suprafenacine pictures 2026-07-04 Suprafenacine
1477482-50-0
 $35.00-113.00 99.91% 10g TargetMol Chemicals Inc.
  • Suprafenacine pictures
  • Suprafenacine
    1477482-50-0
  • $35.00-113.00
  • 99.91%
  • TargetMol Chemicals Inc.

Suprafenacine Spectrum

Suprafenacine(1477482-50-0)1HNMR

1477482-50-0 (Suprafenacine) Related Search:

Methanone, [2-(1H-indol-3-yl)-1H-imidazol-5-yl](3,4,5-trimethoxyphenyl)- S-72 B014 AVE8062A NA
Albendazole

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Suprafenacine N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide N-[(E)-(4-methylphenyl)methylideneamino]-4,5,6,7-tetrahydro-1~{H}-indazole-3-carboxamide 1H-Indazole-3-carboxylic acid, 4,5,6,7-tetrahydro-, (2E)-2-[(4-methylphenyl)methylene]hydrazide Suprafenacine >=98% (HPLC) 7-tetrahydro-1H-indazole-3-carbohydrazide N'-[(E)-(4-methylphenyl)methylidene]-4 Suprafenacine, 10 mM in DMSO 4,5,6,7-TETRAHYDRO-1H-INDAZOLE-3-CARBOXYLIC ACID (4-METHYL-BENZYLIDENE)HYDRAZIDE 1477482-50-0