Suprafenacine manufacturers
- Suprafenacine
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- $35.00
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2026-07-04
- CAS:1477482-50-0
- Purity: 99.91%
- Supply Ability: 10g
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| | Suprafenacine Basic information |
| Product Name: | Suprafenacine | | Synonyms: | Suprafenacine;N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide;N-[(E)-(4-methylphenyl)methylideneamino]-4,5,6,7-tetrahydro-1~{H}-indazole-3-carboxamide;1H-Indazole-3-carboxylic acid, 4,5,6,7-tetrahydro-, (2E)-2-[(4-methylphenyl)methylene]hydrazide;Suprafenacine >=98% (HPLC);7-tetrahydro-1H-indazole-3-carbohydrazide;N'-[(E)-(4-methylphenyl)methylidene]-4;Suprafenacine, 10 mM in DMSO | | CAS: | 1477482-50-0 | | MF: | C16H18N4O | | MW: | 282.34 | | EINECS: | | | Product Categories: | | | Mol File: | 1477482-50-0.mol |  |
| | Suprafenacine Chemical Properties |
| density | 1.284±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 10 mg/ml | | form | A solid | | pka | 12.107±0.20(predicted) | | color | White to off-white |
| | Suprafenacine Usage And Synthesis |
| Uses | Suprafenacine is a cell permeable, tubulin-destabilizing molecule which bind microtubules at the colchicine-binding site and inhibit polymerization. Suprafenacine can induce G2/M cell cycle arrest and apoptosis, and can be used for cancer research[1]. | | Biological Activity | Suprafenacine is an inhibitor of tubulin polymerization (IC50 = 0.38 μM) with anticancer activity.1 It inhibits the proliferation of HeLa, Jurkat, SNU-16, MDA-MB-231, A549, SH-SY5Y, HCT15, and KB-3-1 cells (IC50s = 83-381.2 nM) and P-glycoprotein-enriched KB-VI cells (IC50 = 215.7 nM). Suprafenacine (10 μM) increases phosphorylation of JNK and Bcl-2 and induces apoptosis and cell cycle arrest at the G2/M phase in HeLa cells. Suprafenacine (20 mg/kg) reduces tumor growth in an HCT15 colon adenocarcinoma mouse xenograft model. | | in vivo | Suprafenacine (20 mg/kg, i.p., every 3 days for 9 days) suppresses 40% of tumor mass in HCT15 tumor bearing SCID mice compared with control mice[1].
| | References | 1.Choi, B.-H., Chattopadhaya, S., Thanh, L.N., et al.Suprafenacine, an indazole-hydrazide agent, targets cancer cells through microtubule destabilizationPLoS One9(10)e110955(2014) |
| | Suprafenacine Preparation Products And Raw materials |
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