Cefiderocol
- CAS No.
- 1225208-94-5
- Chemical Name:
- Cefiderocol
- Synonyms
- Cefiderocol;2H6]-Cefiderocol;2H8]-Cefiderocol;Cefiderocol (S-649266);(6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-3-((1-(2-(2-chloro-3,4-dihydroxybenzamido)ethyl)pyrrolidin-1-ium-1-yl)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;Pyrrolidinium, 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-[2-[(2-chloro-3,4-dihydroxybenzoyl)amino]ethyl]-, inner salt (ACI)
- CBNumber:
- CB83159907
- Molecular Formula:
- C30H34ClN7O10S2
- Molecular Weight:
- 752.21
- MDL Number:
- MFCD30533432
- MOL File:
- 1225208-94-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Store at -20°C, stored under nitrogen,unstable in solution, ready to use. |
|---|---|
| solubility | DMSO:50.0(Max Conc. mg/mL);66.47(Max Conc. mM) |
| form | Solid |
| color | White to off-white |
| InChIKey | DBPPRLRVDVJOCL-OLKYWZQRNA-N |
| SMILES | C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3N=C(N)SC=3)=N\OC(C)(C)C(=O)O)C(=O)N12)C[N+]1(CCCC1)CCNC(C1C=CC(O)=C(O)C=1Cl)=O)(=O)[O-] |&1:5,7,r| |
| FDA UNII | SZ34OMG6E8 |
| ATC code | J01DI04 |
| UNSPSC Code | 12352111 |
| NACRES | NA.76 |
Cefiderocol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SBR00041 | Cefiderocol | 1225208-94-5 | 2 mg | $369 | 2026-04-30 | Buy |
| Biosynth | FC178665 | Cefiderocol | 1225208-94-5 | 1mg | $665.5 | 2026-06-04 | Buy |
| Biosynth | FC178665 | Cefiderocol | 1225208-94-5 | 2mg | $998.26 | 2026-06-04 | Buy |
| Biosynth | FC178665 | Cefiderocol | 1225208-94-5 | 5mg | $1497.4 | 2026-06-04 | Buy |
| Biosynth | FC178665 | Cefiderocol | 1225208-94-5 | 10mg | $2329.3 | 2026-06-04 | Buy |
Cefiderocol Chemical Properties, Uses, Production
Uses
Cefiderocol, is a novel parenteral siderophore cephalosporin conjugated with a catechol moiety, that has a characteristic antibacterial spectrum with a potent activity against a broad range of aerobic Gram-negative bacterial species,
reaction suitability
reagent type: chelator
Pharmaceutical Applications
Cefiderocol can be used for the treatment of complicated urinary tract infections (cUTIs) when other treatment options are limited or nonexistent.
Biological Activity
Mode of Action: Cefiderocol binds to specific proteins called penicillin-binding proteins (PBPs) located on the bacterial cell wall. This binding affinity inhibits the synthesis of the bacterial cell wall, leading to cell lysis and bacterial death.
Antimicrobial Spectrum: Cefiderocol has strong antimicrobial properties, especially against a wide spectrum of Gram-negative pathogens. Due to its siderophore core it is also a natural iron-chelator, which adds to its antibacterial activities.
Synthesis
Below shows the synthesis route of Cefiderocol
IC 50
β-lactam
Cefiderocol Preparation Products And Raw materials
Raw materials
Preparation Products
Cefiderocol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangsu yize medical technology co. LTD | 18962082606 | 3394205705@qq.com | China | 1751 | 58 |
| Haiji Pharmaceutical Technology (Suzhou) Co., Ltd | 18012778619 | 3394205705@qq.com | China | 9902 | 58 |
| Taizhou Nanfeng Pharmaceutical Research Institute | nanfengpharma@126.co 18616377689 | nanfengpharma@126.com | China | 20008 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14905 | 59 |
| TaiChem Taizhou Limited | 052386810091 | zcwy9518@yeah.net | China | 3917 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
Related articles
- A brief introduction to Cefiderocol
- Cefiderocol is a novel catechol-substituted siderophore cephalosporin for injection that uses the bacterial active iron transp....
- Jan 4,2024
