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ChemicalBook >> CAS DataBase List >>(Z)-2-Carboxy-4,6-dichloroindole-3-(2'-phenyl-2'-carboxy)-ene

(Z)-2-Carboxy-4,6-dichloroindole-3-(2'-phenyl-2'-carboxy)-ene

(Z)-2-Carboxy-4,6-dichloroindole-3-(2'-phenyl-2'-carboxy)-ene Structure
(Z)-2-Carboxy-4,6-dichloroindole-3-(2'-phenyl-2'-carboxy)-ene structure
CAS No.
161230-88-2
Chemical Name:
(Z)-2-Carboxy-4,6-dichloroindole-3-(2'-phenyl-2'-carboxy)-ene
Synonyms
MDL-105212;MDL 105,519;MDL 105,519 >=98% (HPLC), solid;(Z)-2-Carboxy-4,6-dichloroindole-3-(2'-phenyl-2'-carboxy)-ene;3-[(1E)-2-Carboxy-2-phenylethenyl]-4,6-dichloro-1H-indole-2-carboxylic acid;1H-Indole-2-carboxylic acid, 3-[(1E)-2-carboxy-2-phenylethenyl]-4,6-dichloro-
CBNumber:
CB8317737
Molecular Formula:
C18H11Cl2NO4
Molecular Weight:
376.19
MDL Number:
MFCD00935266
MOL File:
Mol file
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:38
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(Z)-2-Carboxy-4,6-dichloroindole-3-(2'-phenyl-2'-carboxy)-ene Properties

Boiling point 601.3±55.0 °C(Predicted)
Density 1.594±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 5 mg/mL
pka 3.20±0.19(Predicted)
form solid
color white
InChI 1S/C18H11Cl2NO4/c19-10-6-13(20)15-12(16(18(24)25)21-14(15)7-10)8-11(17(22)23)9-4-2-1-3-5-9/h1-8,21H,(H,22,23)(H,24,25)/b11-8-
InChIKey LPWVUDLZUVBQGP-FLIBITNWSA-N
SMILES OC(=O)C(=C/c1c([nH]c2cc(Cl)cc(Cl)c12)C(O)=O)\c3ccccc3
FDA UNII PP86UX2L28
UNSPSC Code 12352200
NACRES NA.32

SAFETY

Risk and Safety Statements

PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
Storage Class 11 - Combustible Solids

(Z)-2-Carboxy-4,6-dichloroindole-3-(2'-phenyl-2'-carboxy)-ene price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M216 MDL 105,519 ≥98% (HPLC), solid 161230-88-2 5mg $737 2026-04-30 Buy
Sigma-Aldrich M216 MDL 105,519 ≥98% (HPLC), solid 161230-88-2 25mg $2960 2026-04-30 Buy
Biosynth FC65085 MDL 105519 161230-88-2 10mg $240.5 2026-06-04 Buy
Biosynth FC65085 MDL 105519 161230-88-2 25mg $505.25 2026-06-04 Buy
Biosynth FC65085 MDL 105519 161230-88-2 50mg $841.5 2026-06-04 Buy
Product number Packaging Price Buy
M216 5mg $737 Buy
M216 25mg $2960 Buy
FC65085 10mg $240.5 Buy
FC65085 25mg $505.25 Buy
FC65085 50mg $841.5 Buy

(Z)-2-Carboxy-4,6-dichloroindole-3-(2'-phenyl-2'-carboxy)-ene Chemical Properties, Uses, Production

Uses

MDL 105519 is a potent and selective antagonist of glycine binding to the NMDA receptor.

Biochem/physiol Actions

MDL 105,519 is a high affinity N-methyl-D-aspartate (NMDA) glutamate receptor antagonist at the glycine site. It inhibits NMDA-dependent responses.

in vivo

MDL 105519 is an NMDA receptor antagonistin vivo. Intravenously administration of MDL 105519 prevents harmaline-stimulated increases in cerebellar cyclic GMP content, providing biochemical evidence of NMDA receptor antagonism in vivo. This antagonism is associated with anticonvulsant activity in genetically based, chemically induced, and electrically mediated seizure models. Anxiolytic activity is observed in the rat separation-induced vocalization model, but muscle-relaxant activity is apparent at lower doses. Higher doses impair rotorod performance, but are without effect on mesolimbic dopamine turnover or prepulse inhibition of the startle reflex[1].

IC 50

NMDA Receptor

References

[1] Baron BM, et al. Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist. Eur J Pharmacol. 1997 Apr 4;323(2-3):181-92. DOI:10.1016/s0014-2999(97)00045-9

(Z)-2-Carboxy-4,6-dichloroindole-3-(2'-phenyl-2'-carboxy)-ene Preparation Products And Raw materials

Raw materials

Preparation Products

(Z)-2-Carboxy-4,6-dichloroindole-3-(2'-phenyl-2'-carboxy)-ene Suppliers

Global Suppliers ( 43)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Taizhou Jinghao Chemical Co., Ltd. 86-576-88550069 13486888296 sales@jinghaochem.com China 37 55
Guangzhou QiYun Biotechnology Co., Ltd. 020-61288194 61288195 505721671@qq.com China 3853 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Musechem +1-800-259-7612 info@musechem.com United States 4648 60
Jinan Yaoyan Pharmaceutical Co., Ltd. jnyaoyan@163.com China 3057 58
Supplier Advantage
BOC Sciences 65
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
Sigma-Aldrich 80
Taizhou Jinghao Chemical Co., Ltd. 55
Guangzhou QiYun Biotechnology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Amadis Chemical Company Limited 58
Musechem 60
Jinan Yaoyan Pharmaceutical Co., Ltd. 58

View Latest Price from (Z)-2-Carboxy-4,6-dichloroindole-3-(2'-phenyl-2'-carboxy)-ene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MDL 105519 pictures 2026-05-11 MDL 105519
161230-88-2
 $99.00 99.67% 10g TargetMol Chemicals Inc.
  • MDL 105519 pictures
  • MDL 105519
    161230-88-2
  • $99.00
  • 99.67%
  • TargetMol Chemicals Inc.

161230-88-2 ((Z)-2-Carboxy-4,6-dichloroindole-3-(2'-phenyl-2'-carboxy)-ene) Related Search:

Cholesterol esterase 3-Methylstyrene 4,6-Dichloro-1H-indole (Z)-MDL 105519 Ethyl 3-(2-carboxy-vinyl)-4,6-dichloro-1H-indole-2-carboxylate
(Z)-2-Carboxy-4,6-dichloroindole-3-(2'-phenyl-2'-carboxy)-ene

1of2

MDL-105212 MDL 105,519 3-[(1E)-2-Carboxy-2-phenylethenyl]-4,6-dichloro-1H-indole-2-carboxylic acid 1H-Indole-2-carboxylic acid, 3-[(1E)-2-carboxy-2-phenylethenyl]-4,6-dichloro- MDL 105,519 >=98% (HPLC), solid (Z)-2-Carboxy-4,6-dichloroindole-3-(2'-phenyl-2'-carboxy)-ene 161230-88-2 C18H11Cl2NO4