2-(2-Chlorophenyl)glycine
- CAS No.
- 88744-36-9
- Chemical Name:
- 2-(2-Chlorophenyl)glycine
- Synonyms
- DL-2-CHLOROPHENYLGLYCINE;2-CHLOROPHENYLGLYCINE;RARECHEM AK ML 0504;2-(2-Chlorophenyl)glycine;2-CHLORO-DL-PHENYLGLYCINE;(±)-2-Chlorophenylglycine;(+/-)-2-CHLOROPHENYLGLYCINE;(+/-)-2-Chlorophenyl glycine;2-(2-Chlorophenyl)glycine >2-(2-Chlorophenyl)-dl-glycine
- CBNumber:
- CB8325761
- Molecular Formula:
- C8H8ClNO2
- Molecular Weight:
- 185.61
- MDL Number:
- MFCD00049324
- MOL File:
- 88744-36-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 218-220 °C (decomp) |
|---|---|
| Boiling point | 318.8±32.0 °C(Predicted) |
| Density | 1.392±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| form | Powder |
| pka | 1.69±0.10(Predicted) |
| color | White to off-white |
| Sensitive | Air Sensitive |
| Major Application | peptide synthesis |
| InChI | 1S/C8H8ClNO2/c9-6-4-2-1-3-5(6)7(10)8(11)12/h1-4,7H,10H2,(H,11,12) |
| InChIKey | LMIZLNPFTRQPSF-UHFFFAOYSA-N |
| SMILES | NC(C(O)=O)c1ccccc1Cl |
| CAS DataBase Reference | 88744-36-9(CAS DataBase Reference) |
| FDA UNII | 33MO79FI81 |
| UNSPSC Code | 12352200 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| F | 10-23 |
| HS Code | 29224985 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
2-(2-Chlorophenyl)glycine price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C2579 | 2-(2-Chlorophenyl)glycine >98.0%(HPLC)(T) | 88744-36-9 | 5g | $203 | 2026-04-30 | Buy |
| TCI Chemical | C2579 | 2-(2-Chlorophenyl)glycine >98.0%(HPLC)(T) | 88744-36-9 | 25g | $458 | 2022-04-27 | Buy |
| AstaTech | 28172 | 2-AMINO-2-(2-CHLOROPHENYL)ACETIC ACID 98% | 88744-36-9 | 100G | $33 | 2026-04-30 | Buy |
| ChemScene | CS-W002235 | 2-Chlorophenylglycine ≥98% | 88744-36-9 | 100g | $10 | 2026-06-04 | Buy |
| ChemScene | CS-W002235 | 2-Chlorophenylglycine ≥98% | 88744-36-9 | 500g | $35 | 2026-06-04 | Buy |
2-(2-Chlorophenyl)glycine Chemical Properties, Uses, Production
Description
2-(2-Chlorophenyl)glycine is a pharmaceutical intermediate ingredient used in the preparation of Clopidogrel hydrogensulfate, an antiplatelet drug used to prevent blood clots.
Uses
2-Chlorophenylglycine is a Glycine (HY-Y0966) derivative[1].
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
143-33-9
89-98-5
86169-24-6
The general procedure for the synthesis of (R)-2-amino-2-(2-chlorophenyl)acetic acid from sodium cyanide and o-chlorobenzaldehyde was as follows: 2-chlorophenylglycine was prepared according to the method described in Scheme 1. O-chlorobenzaldehyde (2-chlorobenzaldehyde), ammonium bicarbonate (NH4HCO3, 23.7 g) and sodium cyanide (NaCN, 14.7 g) were dissolved in a mixed solvent of 500 ml of methanol and 500 ml of water, and the reaction was stirred for 5 hours at 65-70 °C. Upon completion of the reaction, the solution was concentrated and transferred to an autoclave, where 45% sodium hydroxide (NaOH) solution was added and refluxed at 120°C for 4 hours. After the reaction mixture was cooled, 2 g of activated carbon was added and stirred for 10 minutes for decolorization. The activated carbon was removed by filtration and the pH of the filtrate was adjusted to 7-8 with 50% sulfuric acid (H2SO4). the precipitate was collected by filtration and washed with water to give 27 g (58% yield) of 2-chlorophenylglycine. The product was RS-2-chlorophenylglycine with a specific optical rotation of +0.16 (C=1, 1N HCl) and a melting point of 185.4-186.8 °C. The product was a mixture of RS-2-chlorophenylglycine, RS-2-chlorophenylglycine and RS-2-chlorophenylglycine.
References
[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368
2-(2-Chlorophenyl)glycine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
View Latest Price from 2-(2-Chlorophenyl)glycine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | AMINO-(2-CHLORO-PHENYL)-ACETIC ACID
88744-36-9
|
$3.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- AMINO-(2-CHLORO-PHENYL)-ACETIC ACID
88744-36-9
- $3.00
- 99%
- Career Henan Chemical Co
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