Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
![Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Structure](CAS/20200401/GIF/5184-64-5.gif)
- CAS No.
- 5184-64-5
- Chemical Name:
- Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
- Synonyms
- ESI-05;NSC 116966;ESI-05 (ESI05);ESI-05 (NSC 116966);ESI-05 >=98% (HPLC);ESI-05, 10 mM in DMSO;MESITYL P-TOLYL SULFONE;1,3,5-trimethyl-2-tosylbenzene;1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene;Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
- CBNumber:
- CB83290819
- Molecular Formula:
- C16H18O2S
- Molecular Weight:
- 274.38
- MDL Number:
- MFCD00091573
- MOL File:
- 5184-64-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1907 | ESI-05 ≥98% (HPLC) | 5184-64-5 | 5mg | $98.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1907 | ESI-05 ≥98% (HPLC) | 5184-64-5 | 25mg | $397 | 2026-04-30 | Buy |
| Sigma-Aldrich | S798975 | MESITYL P-TOLYL SULFONE AldrichCPR | 5184-64-5 | 50MG | $197 | 2026-04-30 | Buy |
| Cayman Chemical | 29702 | ESI-05 ≥95% | 5184-64-5 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 29702 | ESI-05 ≥95% | 5184-64-5 | 5mg | $103 | 2026-04-30 | Buy |
Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Chemical Properties, Uses, Production
Uses
ESI-05 has been used to study the effect of protein exchange directly activated by cAMP 2 on traumatic brain injury.
Biochem/physiol Actions
ESI-05 is a selective inhibitor against cAMP-regulated guanine nucleotide exhange factor (GEF) EPAC2 (Exchange factor directly activated by cAMP 2) activation by targeting an EPAC2-specific allosteric site at the interface of the two cAMP-binding domains. ESI-05 inhibits EAPC2, but not EPAC1 or PKA, activation by cAMP in a highly potent (IC50 = 430 nM; 25 μM cAMP) and cAMP-competitive manner in cell-free assays, and suppresses cAMP analog 007-AM-induced cellular Rap1 activation in EPAC2-, but not EPAC1-, expressing HEK293 transfectants.
in vivo
ESI-05 (2, 4, and 8 mg/kg) decreases neuronal apoptosis by inhibiting the p38/BIM pathway in vivo[2].
| Animal Model: | Intracranial hemorrhage (ICH) model[2] |
| Dosage: | 2, 4, and 8 mg/kg |
| Administration: | |
| Result: | Decreased the apoptosis rate of nerve cells in the cortex accompanied by a corresponding decrease in the protein expression of phosphorylated p38, Bcl-2like protein 11 (BIM), and caspase-3. |
storage
Store at RT
Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9780 | 55 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| Cool Pharm, Ltd | 021-58581007 18019463053 | sales@coolpharm.com | China | 9999 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
