1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[(1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride
![1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[(1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride Structure](CAS/GIF/168986-61-6.gif)
- CAS No.
- 168986-61-6
- Chemical Name:
- 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[(1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride
- Synonyms
- RS 67506;RS67506HCl;RS 67506 HYDROCHLORIDE;N-[2-[4-[3-(4-amino-5-chloro-2-methoxyphenyl)-3-oxopropyl]piperidin-1-yl]ethyl]methanesulfonamide;1-(4-Amino-5-chloro-2-methoxyphenyl)-3-(1-2-methylsulfonylamino)ethyl-4-piperidinyl)-1-propanonehydrochloride;N-(2-(4-(3-(4-Amino-5-chloro-2-methoxyphenyl)-3-oxopropyl)piperidin-1-yl)ethyl)methanesulfonamide hydrochloride;1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride;1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[(1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride
- CBNumber:
- CB8335375
- Molecular Formula:
- C18H29Cl2N3O4S
- Molecular Weight:
- 454.41
- MDL Number:
- MFCD00938574
- MOL File:
- 168986-61-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[(1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | TGA98661 | RS 67506 hydrochloride | 168986-61-6 | 100mg | $1061 | 2026-06-05 | Buy |
| ApexBio Technology | B6536 | RS 67506 hydrochloride | 168986-61-6 | 10mg | $158 | 2026-05-06 | Buy |
| ApexBio Technology | B6536 | RS 67506 hydrochloride | 168986-61-6 | 50mg | $660 | 2026-05-06 | Buy |
| TRC | R701028 | RS67506Hydrochloride | 168986-61-6 | 10mg | $135 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0123570 | 1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE 95.00% | 168986-61-6 | 5MG | $495.14 | 2021-12-16 | Buy |
1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[(1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride Chemical Properties,Uses,Production
Uses
RS 67506 Hydrochloride is a novel and potent 5-HT4 receptor agonist.
Definition
ChEBI: A hydrochloride salt obtained by mixing equimolar amounts of RS 39604 with hydrochloric acid. A potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and alpha1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.
Biological Activity
A potent and selective 5-HT 4 partial agonist, with a pK i of 8.8 at 5-HT 4 sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT 1A, 1D, 2A, 2C , D 1 , D 2 and M 1-3 . It is active in vivo and has an intrinsic activity compared to 5-HT of 0.6.
in vitro
rs 67506 acted as a potent partial agonist with respect to 5-ht at the 5-ht4 receptor regulating relaxation of the carbachol-precontracted oesophagus. relaxant responses to rs 67506 was surmountably antagonized with apparent affinities (pkb) of 9.0. rs 67506, therefore, acted as potent, partial 5-ht4 receptor agonists in vitro. the compound may have been used in elucidating the physiological role in 5-ht4 receptors by virtue of their high potency and selectivity [1].
in vivo
rs 67506 induced dose-dependent potentiates heart rate of the anaesthetized micropig (ed50 5.4 pg kg-1, i.v.) with maximal increases of 47 beats min-1 [1]. in addition, in a rat model of spatial learning and memory, the effects of two novel potent and selective 5-ht4 receptor agonists (rs67333 and rs67506) were studied. by contrast, there was no effect seen to rs67506 (0.1, 10 and 1000 pg/kg, i.p.) of equivalent potency and selectivity to rs67333.this differential result may suggest the enhanced ability of rs67333 to enter the cns, with respect to rs67506 [2].
References
[1]. eglen rm, bonhaus dw, johnson lg, leung e, clark rd. pharmacological characterization of two novel and potent 5-ht4 receptor agonists, rs 67333 and rs 67506, in vitro and in vivo. br j pharmacol. 1995 aug;115(8):1387-92.
[2]. fontana dj, daniels se, wong eh, clark rd, eglen rm. the effects of novel, selective 5-hydroxytryptamine (5-ht) 4 receptor ligands in rat spatial navigation. neuropharmacology. 1997 apr-may;36(4-5):689-96.
1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[(1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[(1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5987 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| Supplier | Advantage |
|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 69 |
| EMMX Biotechnology LLC | 60 |
| Nantong QuanYi Biotechnology Co., Ltd | 58 |
| Alchem Pharmtech,Inc. | 58 |
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