LOXO-195
- CAS No.
- 2097002-61-2
- Chemical Name:
- LOXO-195
- Synonyms
- Selitrectinib;CS-2800;LOXO-195;LOXO195;LOXO-195(3aR,10R);LOXO-195 USP/EP/BP;LOXO-195(Slitrecrinib);LOXO 195(Selitrectinib);selitrectinib（LOXO-195）;Selitrectinib (BAY 2731954;Selitrectinib, 10 mM in DMSO
- CBNumber:
- CB83367232
- Molecular Formula:
- C20H21FN6O
- Molecular Weight:
- 380.42
- MDL Number:
- MFCD31620755
- MOL File:
- 2097002-61-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| LOXO-195 ≥98% | 27062 | 1mg | $28 |
| LOXO-195 ≥98% | 27062 | 5mg | $97 |
| LOXO-195 ≥98% | 27062 | 10mg | $165 |
| LOXO-195 | 27062 | 5mg | $684 |
| LOXO-195 | 27062 | 10mg | $1139 |
| More product size | |||
| Density | 1.51±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO:62.5(Max Conc. mg/mL);164.29(Max Conc. mM) |
| form | A crystalline solid |
| pka | 11.44±0.40(Predicted) |
| color | White to yellow |
| InChI | InChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12-,17-/m1/s1 |
| InChIKey | OEBIHOVSAMBXIB-SJKOYZFVSA-N |
| SMILES | N12CCC[C@]1([H])C1=CC(F)=CN=C1CC[C@@H](C)NC(=O)C1C=NN3C=CC2=NC=13 |
| FDA UNII | 0J45910S3X |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
LOXO-195 price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27062 | LOXO-195 ≥98% | 2097002-61-2 | 1mg | $28 | 2026-04-30 | Buy |
| Cayman Chemical | 27062 | LOXO-195 ≥98% | 2097002-61-2 | 5mg | $97 | 2026-04-30 | Buy |
| Cayman Chemical | 27062 | LOXO-195 ≥98% | 2097002-61-2 | 10mg | $165 | 2026-04-30 | Buy |
| Cayman Chemical | 27062 | LOXO-195 | 2097002-61-2 | 5mg | $684 | 2024-03-01 | Buy |
| Cayman Chemical | 27062 | LOXO-195 | 2097002-61-2 | 10mg | $1139 | 2024-03-01 | Buy |
LOXO-195 Chemical Properties,Uses,Production
Uses
LOXO-195 (Selitrectinib) is a second-generation TRK kinase inhibitor that targets TRK fusion-positive tumors and is used to treat tumor patients who are resistant to first-generation TRK inhibitors.
in vivo
Stably transfected NIH-3T3 ΔTRKA and ΔTRKA-G595R cells are implanted subcutaneously into the flanks of nude mice. Both larotrectinib and Selitrectinib (LOXO-195) are effective at reducing phosphorylated TRKA in tumors driven by ΔTRKA. In contrast, only Selitrectinib (LOXO-195) strongly suppresses phospho-TRKA in ΔTRKA-G595R cells in a dose-dependent manner. Selitrectinib (LOXO-195) also causes inhibition of tumor growth relative to vehicle at all doses in four TRKA-dependent tumor models (ΔTRKA, ΔTRKA-G595R, ΔTRKAG667C, and TPM3-NTRK1 fusion-positive KM12 colorectal cancer cells. Larotrectinib inhibits KM12 and NIH 3T3-ΔTRKA tumors to a similar degree. Group mean body weight loss does not exceed 5% for any agent. Selitrectinib (LOXO-195) displays high selectivity for the TRK proteins[1]
IC 50
TrkA: 0.6 nM (IC50); TrkC: <2.5 nM (IC50)
LOXO-195 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Dideu Industries Group Limited | +86-86-15536356810 +8617392712697 | 1022@dideu.com | China | 29068 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10457 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8645 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
View Lastest Price from LOXO-195 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | Selitrectinib
2097002-61-2
|
$34.00-122.00 | 99.97% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-06 | LOXO-195
2097002-61-2
|
1KG | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-11-18 | LOXO-195 USP/EP/BP
2097002-61-2
|
$1.10 | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- Selitrectinib
2097002-61-2
- $34.00-122.00
- 99.97%
- TargetMol Chemicals Inc.
-
- LOXO-195
2097002-61-2
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- LOXO-195 USP/EP/BP
2097002-61-2
- $1.10
- 99.9%
- Dideu Industries Group Limited
