LOXO-195
- CAS No.
- 2097002-61-2
- Chemical Name:
- LOXO-195
- Synonyms
- Selitrectinib;CS-2800;LOXO-195;LOXO195;LOXO-195(3aR,10R);LOXO-195 USP/EP/BP;LOXO-195(Slitrecrinib);LOXO 195(Selitrectinib);selitrectinib（LOXO-195）;Selitrectinib (BAY 2731954;Selitrectinib, 10 mM in DMSO
- CBNumber:
- CB83367232
- Molecular Formula:
- C20H21FN6O
- Molecular Weight:
- 380.42
- MDL Number:
- MFCD31620755
- MOL File:
- 2097002-61-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.51±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO:62.5(Max Conc. mg/mL);164.29(Max Conc. mM) |
| form | A crystalline solid |
| pka | 11.44±0.40(Predicted) |
| color | White to yellow |
| InChI | InChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12-,17-/m1/s1 |
| InChIKey | OEBIHOVSAMBXIB-SJKOYZFVSA-N |
| SMILES | N12CCC[C@]1([H])C1=CC(F)=CN=C1CC[C@@H](C)NC(=O)C1C=NN3C=CC2=NC=13 |
| FDA UNII | 0J45910S3X |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
LOXO-195 price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27062 | LOXO-195 ≥98% | 2097002-61-2 | 1mg | $28 | 2026-04-30 | Buy |
| Cayman Chemical | 27062 | LOXO-195 ≥98% | 2097002-61-2 | 5mg | $97 | 2026-04-30 | Buy |
| Cayman Chemical | 27062 | LOXO-195 ≥98% | 2097002-61-2 | 10mg | $165 | 2026-04-30 | Buy |
| ChemScene | CS-0022378 | Selitrectinib 99.74% | 2097002-61-2 | 5mg | $108 | 2026-06-04 | Buy |
| ChemScene | CS-0022378 | Selitrectinib 99.74% | 2097002-61-2 | 10mg | $162 | 2026-06-04 | Buy |
LOXO-195 Chemical Properties, Uses, Production
Uses
LOXO-195 (Selitrectinib) is a second-generation TRK kinase inhibitor that targets TRK fusion-positive tumors and is used to treat tumor patients who are resistant to first-generation TRK inhibitors.
in vivo
Stably transfected NIH-3T3 ΔTRKA and ΔTRKA-G595R cells are implanted subcutaneously into the flanks of nude mice. Both larotrectinib and Selitrectinib (LOXO-195) are effective at reducing phosphorylated TRKA in tumors driven by ΔTRKA. In contrast, only Selitrectinib (LOXO-195) strongly suppresses phospho-TRKA in ΔTRKA-G595R cells in a dose-dependent manner. Selitrectinib (LOXO-195) also causes inhibition of tumor growth relative to vehicle at all doses in four TRKA-dependent tumor models (ΔTRKA, ΔTRKA-G595R, ΔTRKAG667C, and TPM3-NTRK1 fusion-positive KM12 colorectal cancer cells. Larotrectinib inhibits KM12 and NIH 3T3-ΔTRKA tumors to a similar degree. Group mean body weight loss does not exceed 5% for any agent. Selitrectinib (LOXO-195) displays high selectivity for the TRK proteins[1]
IC 50
TrkA: 0.6 nM (IC50); TrkC: <2.5 nM (IC50)
LOXO-195 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Fulangke Chemical Technology Co., Ltd. | 13776872728 | amwpl888@sina.cn | China | 24 | 58 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9513 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Shanghai YuanQi Biotechnology Co., Ltd. | +86-2332782371 +86-18120098618 | sales@adobechem.com | China | 1250 | 50 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4860 | 55 |
View Latest Price from LOXO-195 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | LOXO-195 USP/EP/BP
2097002-61-2
|
$1.10 | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2026-07-14 | Selitrectinib
2097002-61-2
|
$34.00-122.00 | 99.97% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-06 | LOXO-195
2097002-61-2
|
1KG | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd |
-
- LOXO-195 USP/EP/BP
2097002-61-2
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- Selitrectinib
2097002-61-2
- $34.00-122.00
- 99.97%
- TargetMol Chemicals Inc.
-
- LOXO-195
2097002-61-2
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
